SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		4 / 8 LEU A 266
PHE A 259
GLY A 262
TRP A 331
 None
 1.04A 1fapB-1x2gA:
undetectable		 1fapB-1x2gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		4 / 8 LEU A 154
VAL A 113
LEU A 108
ALA A 202
 None
 0.89A 1fiqC-1x2gA:
undetectable		 1fiqC-1x2gA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		5 / 10 ALA A 107
PHE A 208
ALA A 209
PHE A  86
ILE A 103
 None
 1.21A 1g5yC-1x2gA:
undetectable		 1g5yC-1x2gA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		5 / 12 THR A 101
LEU A 105
LEU A 187
LEU A 108
LEU A 153
 None
 1.13A 1mx1C-1x2gA:
undetectable		 1mx1C-1x2gA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		5 / 12 THR A 101
VAL A 104
LEU A 187
LEU A 108
LEU A 153
 None
 1.12A 1mx1C-1x2gA:
undetectable		 1mx1C-1x2gA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		5 / 11 GLY A  75
GLY A  74
PRO A 249
HIS A 267
LEU A 254
 None
 1.21A 1p91A-1x2gA:
undetectable		 1p91A-1x2gA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		3 / 3 GLU A  21
HIS A 149
GLU A  20
 None
 0.75A 2x45B-1x2gA:
undetectable		 2x45B-1x2gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		3 / 3 GLU A  21
HIS A 149
GLU A  20
 None
 0.79A 2x45C-1x2gA:
undetectable		 2x45C-1x2gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		5 / 9 GLY A 146
ASP A 144
ALA A  29
GLY A  91
VAL A  33
 None
 1.45A 4c5lB-1x2gA:
undetectable		 4c5lB-1x2gA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		5 / 10 GLY A 146
ASP A 144
ALA A  29
GLY A  91
VAL A  33
 None
 1.48A 4c5lD-1x2gA:
undetectable		 4c5lD-1x2gA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		5 / 12 GLU A  54
ASN A  50
GLY A  46
ARG A 258
ILE A  45
 None
 1.43A 4djfA-1x2gA:
undetectable		 4djfA-1x2gA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		4 / 5 VAL A  33
ARG A   4
GLU A 218
LEU A 228
 None
 1.11A 4hojA-1x2gA:
undetectable		 4hojA-1x2gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		3 / 3 VAL A 128
GLY A 130
LYS A 126
 None
 0.65A 4k50A-1x2gA:
undetectable		 4k50A-1x2gA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		3 / 3 VAL A 128
GLY A 130
LYS A 126
 None
 0.62A 4k50E-1x2gA:
undetectable		 4k50E-1x2gA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		3 / 3 PRO A 287
VAL A 280
HIS A 267
 None
 0.81A 4pevC-1x2gA:
undetectable		 4pevC-1x2gA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		5 / 12 HIS A 148
LEU A  34
ALA A 107
LEU A 152
GLY A 150
 None
 1.20A 4qckA-1x2gA:
undetectable		 4qckA-1x2gA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		4 / 4 VAL A 215
ALA A 217
PHE A 208
THR A 204
 None
 1.50A 4z4fA-1x2gA:
0.1		 4z4fA-1x2gA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		4 / 4 VAL A 215
ALA A 217
PHE A 208
THR A 204
 None
 1.48A 4z4hA-1x2gA:
0.0		 4z4hA-1x2gA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		5 / 12 VAL A 184
LEU A 153
ALA A 156
ILE A  45
LEU A 165
 None
 1.20A 5hbsA-1x2gA:
undetectable		 5hbsA-1x2gA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		4 / 6 LEU A 123
VAL A 125
THR A 127
LEU A 108
 None
 0.90A 5tudD-1x2gA:
undetectable		 5tudD-1x2gA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		3 / 3 LEU A 293
ALA A 292
LEU A 328
 None
 0.54A 5uunB-1x2gA:
undetectable		 5uunB-1x2gA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		5 / 12 VAL A 104
ASN A 121
GLY A 150
LEU A 187
LEU A 108
 None
 1.01A 5xxiA-1x2gA:
undetectable		 5xxiA-1x2gA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 1x2g LIPOATE-PROTEIN
LIGASE A
(Escherichia
coli) 		3 / 3 ARG A 258
PHE A 259
GLY A 262
 None
 0.72A 6fgdA-1x2gA:
undetectable		 6fgdA-1x2gA:
23.04