SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1x2k OSTEOCLAST
STIMULATING FACTOR 1
(Homo
sapiens) 		3 / 3 TYR A  33
THR A  35
THR A  46
 None
 0.73A 5aoxB-1x2kA:
undetectable		 5aoxB-1x2kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1x2k OSTEOCLAST
STIMULATING FACTOR 1
(Homo
sapiens) 		3 / 3 TYR A  33
THR A  35
THR A  46
 None
 0.66A 5aoxE-1x2kA:
undetectable		 5aoxE-1x2kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1x2k OSTEOCLAST
STIMULATING FACTOR 1
(Homo
sapiens) 		4 / 4 GLU A  23
PRO A  55
ILE A  54
LEU A  53
 None
 1.06A 5m45A-1x2kA:
undetectable		 5m45A-1x2kA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1x2k OSTEOCLAST
STIMULATING FACTOR 1
(Homo
sapiens) 		4 / 4 GLU A  23
PRO A  55
ILE A  54
LEU A  53
 None
 1.10A 5m45D-1x2kA:
0.0		 5m45D-1x2kA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1x2k OSTEOCLAST
STIMULATING FACTOR 1
(Homo
sapiens) 		4 / 4 GLU A  23
PRO A  55
ILE A  54
LEU A  53
 None
 1.04A 5m45G-1x2kA:
undetectable		 5m45G-1x2kA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1x2k OSTEOCLAST
STIMULATING FACTOR 1
(Homo
sapiens) 		4 / 4 GLU A  23
PRO A  55
ILE A  54
LEU A  53
 None
 1.09A 5m45J-1x2kA:
undetectable		 5m45J-1x2kA:
7.97