SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		4 / 8 ASP A 213
THR A 215
HIS A 172
ILE A 223
 None
 0.98A 1ei6C-1x3lA:
2.1		 1ei6C-1x3lA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 10 GLY A 131
ASP A 196
VAL A 197
ASP A 368
ALA A 135
 SO4  A 505 ( 3.7A)
SO4  A 505 ( 4.6A)
None
None
None
 1.30A 1fpqA-1x3lA:
2.4		 1fpqA-1x3lA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 12 LEU A 302
GLY A 301
ALA A 431
LEU A 324
PHE A 326
 None
 1.11A 1gs4A-1x3lA:
undetectable		 1gs4A-1x3lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 LEU A 361
ALA A  20
ALA A  17
VAL A 363
LEU A  11
 None
None
None
None
EDO  A 501 (-3.7A)
 1.26A 1hbpA-1x3lA:
undetectable		 1hbpA-1x3lA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		3 / 3 GLU A 346
HIS A 403
ASP A 299
 None
 0.78A 1i9gA-1x3lA:
4.8		 1i9gA-1x3lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 9 THR A 418
GLY A 369
GLY A 379
PHE A 365
LEU A 416
 None
 1.30A 1jhyA-1x3lA:
2.9		 1jhyA-1x3lA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		3 / 3 ILE A 428
ILE A 430
THR A 291
 None
 0.46A 1rg7A-1x3lA:
undetectable		 1rg7A-1x3lA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 12 ALA A  55
LEU A 128
ALA A  64
VAL A 260
LEU A 116
 None
None
None
EDO  A 502 (-4.3A)
None
 1.13A 1xdkA-1x3lA:
undetectable		 1xdkA-1x3lA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 12 ILE A  67
ALA A  64
ALA A  55
VAL A  33
LEU A  28
 None
 1.14A 1xdkA-1x3lA:
undetectable		 1xdkA-1x3lA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 12 ILE A 127
ALA A  55
ALA A  64
VAL A 260
LEU A 116
 None
None
None
EDO  A 502 (-4.3A)
None
 1.10A 1xdkA-1x3lA:
undetectable		 1xdkA-1x3lA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		4 / 5 GLU A 310
PRO A 317
ILE A 311
GLY A 315
 None
 0.93A 2qeuA-1x3lA:
undetectable
2qeuC-1x3lA:
undetectable		 2qeuA-1x3lA:
16.59
2qeuC-1x3lA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 8 ALA A  55
LEU A 128
LEU A 192
VAL A  31
ILE A  38
 None
 1.27A 2uxpA-1x3lA:
undetectable		 2uxpA-1x3lA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		4 / 7 ILE A  18
ALA A  21
GLY A 422
THR A 421
 None
 0.69A 2xrzB-1x3lA:
undetectable		 2xrzB-1x3lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		4 / 8 ALA A 377
THR A 421
ILE A  18
THR A 418
 None
 0.92A 3bpxA-1x3lA:
undetectable
3bpxB-1x3lA:
undetectable		 3bpxA-1x3lA:
16.59
3bpxB-1x3lA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 12 ILE A 127
ALA A  55
LEU A 128
VAL A 260
LEU A 116
 None
None
None
EDO  A 502 (-4.3A)
None
 1.06A 3dzuA-1x3lA:
undetectable		 3dzuA-1x3lA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 8 LEU A 361
GLY A 379
ALA A 348
ILE A 428
ILE A 362
 None
 1.18A 3ekpA-1x3lA:
undetectable		 3ekpA-1x3lA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 LEU A 361
GLY A 379
ALA A 348
ILE A 428
ILE A 362
 None
 1.09A 3ektD-1x3lA:
undetectable		 3ektD-1x3lA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		3 / 3 ASN A 404
HIS A 403
VAL A 332
 None
 0.91A 3elzB-1x3lA:
undetectable		 3elzB-1x3lA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 10 ALA A  64
GLU A  68
VAL A  73
ALA A 112
ILE A 115
 None
 1.19A 3fl9A-1x3lA:
undetectable		 3fl9A-1x3lA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 9 ALA A 112
LEU A 181
LEU A  56
VAL A  79
SER A 174
 None
 1.29A 3freX-1x3lA:
undetectable		 3freX-1x3lA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		4 / 8 GLU A 203
ASN A 167
ASN A 201
ILE A 205
 None
 1.11A 3kp6A-1x3lA:
undetectable
3kp6B-1x3lA:
undetectable		 3kp6A-1x3lA:
16.93
3kp6B-1x3lA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 10 ALA A 351
ILE A 347
GLY A 379
ILE A 380
ALA A 431
 None
 0.99A 3t3cB-1x3lA:
undetectable		 3t3cB-1x3lA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		4 / 5 LEU A 415
GLY A 414
THR A 385
ILE A 394
 None
 0.83A 3wriA-1x3lA:
undetectable		 3wriA-1x3lA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		4 / 5 LEU A 415
GLY A 414
THR A 385
ILE A 394
 None
 0.82A 3wriB-1x3lA:
undetectable		 3wriB-1x3lA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		4 / 7 GLY A 208
ASP A 213
GLY A 178
HIS A 172
 None
 0.93A 4c5nA-1x3lA:
5.9		 4c5nA-1x3lA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 ILE A  54
ALA A 182
LEU A 181
VAL A 176
LEU A  56
 None
 1.11A 4g1bB-1x3lA:
4.8		 4g1bB-1x3lA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		4 / 8 ILE A 194
ILE A 270
ALA A  20
VAL A 425
 None
 0.70A 4jltA-1x3lA:
undetectable		 4jltA-1x3lA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 9 THR A 418
GLY A 369
GLY A 379
PHE A 365
LEU A 416
 None
 1.34A 4kqiA-1x3lA:
undetectable		 4kqiA-1x3lA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 9 VAL A 169
ILE A 173
ARG A 170
ILE A 241
GLY A 143
 None
None
None
None
EDO  A 503 (-3.7A)
 1.02A 4kukA-1x3lA:
undetectable		 4kukA-1x3lA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		3 / 3 ASP A  22
VAL A  14
ASN A  29
 None
EDO  A 501 ( 4.9A)
None
 0.81A 4lmnA-1x3lA:
1.4		 4lmnA-1x3lA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		4 / 8 LEU A 192
LEU A 128
ASP A  69
ILE A  70
 None
 0.78A 4lzrA-1x3lA:
undetectable		 4lzrA-1x3lA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.44A 4qvmV-1x3lA:
undetectable
4qvmb-1x3lA:
undetectable		 4qvmV-1x3lA:
21.21
4qvmb-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.44A 4qvmH-1x3lA:
undetectable
4qvmN-1x3lA:
undetectable		 4qvmH-1x3lA:
21.21
4qvmN-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.47A 4qvpV-1x3lA:
undetectable
4qvpb-1x3lA:
undetectable		 4qvpV-1x3lA:
21.21
4qvpb-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.46A 4qvqV-1x3lA:
undetectable
4qvqb-1x3lA:
undetectable		 4qvqV-1x3lA:
21.21
4qvqb-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.46A 4qvqH-1x3lA:
undetectable
4qvqN-1x3lA:
undetectable		 4qvqH-1x3lA:
21.21
4qvqN-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.44A 4qvwV-1x3lA:
undetectable
4qvwb-1x3lA:
undetectable		 4qvwV-1x3lA:
21.21
4qvwb-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.43A 4qvwH-1x3lA:
undetectable
4qvwN-1x3lA:
undetectable		 4qvwH-1x3lA:
21.21
4qvwN-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.44A 4qw0H-1x3lA:
undetectable
4qw0N-1x3lA:
undetectable		 4qw0H-1x3lA:
21.21
4qw0N-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.44A 4qw1V-1x3lA:
undetectable
4qw1b-1x3lA:
undetectable		 4qw1V-1x3lA:
21.21
4qw1b-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.45A 4qw1H-1x3lA:
undetectable
4qw1N-1x3lA:
undetectable		 4qw1H-1x3lA:
21.21
4qw1N-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.43A 4qw3V-1x3lA:
undetectable
4qw3b-1x3lA:
undetectable		 4qw3V-1x3lA:
21.21
4qw3b-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.43A 4qw3H-1x3lA:
undetectable
4qw3N-1x3lA:
undetectable		 4qw3H-1x3lA:
21.21
4qw3N-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.45A 4qwuV-1x3lA:
undetectable
4qwub-1x3lA:
undetectable		 4qwuV-1x3lA:
21.21
4qwub-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.45A 4qwuH-1x3lA:
undetectable
4qwuN-1x3lA:
undetectable		 4qwuH-1x3lA:
21.21
4qwuN-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 12 GLY A 342
GLY A 341
GLY A 378
ALA A 376
ILE A 428
 None
 1.04A 4rtmA-1x3lA:
3.3		 4rtmA-1x3lA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 ALA A 112
GLY A 133
VAL A  79
SER A 105
GLY A 108
 None
SO4  A 505 (-4.0A)
None
None
None
 1.08A 4xnxA-1x3lA:
0.4		 4xnxA-1x3lA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		3 / 3 GLU A 346
HIS A 403
ASP A 299
 None
 0.77A 5c0oG-1x3lA:
4.8		 5c0oG-1x3lA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.45A 5cz7H-1x3lA:
undetectable
5cz7N-1x3lA:
undetectable		 5cz7H-1x3lA:
21.21
5cz7N-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.44A 5d0xV-1x3lA:
undetectable
5d0xb-1x3lA:
undetectable		 5d0xV-1x3lA:
21.21
5d0xb-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.44A 5d0xH-1x3lA:
undetectable
5d0xN-1x3lA:
undetectable		 5d0xH-1x3lA:
21.21
5d0xN-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 12 GLY A 208
LEU A 181
ILE A 129
VAL A 211
VAL A 191
 None
 1.11A 5dpdA-1x3lA:
3.3		 5dpdA-1x3lA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 12 GLY A 208
LEU A 181
ILE A 129
VAL A 211
VAL A 191
 None
 1.04A 5dpdB-1x3lA:
3.3		 5dpdB-1x3lA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		3 / 3 ASN A 201
ASP A 213
GLY A 178
 None
 0.47A 5fctB-1x3lA:
undetectable		 5fctB-1x3lA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 10 ALA A 112
ILE A  54
GLY A 133
PHE A 137
VAL A  79
 None
None
SO4  A 505 (-4.0A)
None
None
 1.14A 5i6xA-1x3lA:
undetectable		 5i6xA-1x3lA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 9 LEU A 128
ILE A 190
ILE A 115
VAL A  79
GLU A  68
 None
 1.27A 5igzA-1x3lA:
undetectable		 5igzA-1x3lA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 12 LEU A 107
LEU A 146
ALA A 112
VAL A  79
ALA A  96
 None
 1.06A 5jw1B-1x3lA:
undetectable		 5jw1B-1x3lA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 12 GLY A 342
GLY A 305
ILE A 304
GLY A 379
GLY A 378
 None
 0.88A 5koxA-1x3lA:
undetectable		 5koxA-1x3lA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.45A 5l66V-1x3lA:
undetectable
5l66b-1x3lA:
undetectable		 5l66V-1x3lA:
21.21
5l66b-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 11 SER A 271
THR A 421
THR A 423
GLY A  15
ALA A  17
 None
None
None
EDO  A 501 ( 4.3A)
None
 1.43A 5l66H-1x3lA:
undetectable
5l66N-1x3lA:
undetectable		 5l66H-1x3lA:
21.21
5l66N-1x3lA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		4 / 8 LEU A 146
LEU A 149
LEU A 136
GLY A 132
 None
None
None
SO4  A 505 (-3.3A)
 0.95A 6ce2A-1x3lA:
undetectable		 6ce2A-1x3lA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		5 / 12 ILE A 190
GLY A 189
ILE A 185
ILE A  67
VAL A  73
 None
 1.04A 6emuC-1x3lA:
2.1		 6emuC-1x3lA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		3 / 3 ARG A  90
LYS A  50
TYR A  52
 None
 1.36A 6gnaA-1x3lA:
2.5		 6gnaA-1x3lA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1x3l HYPOTHETICAL PROTEIN
PH0495
(Pyrococcus
horikoshii) 		3 / 3 ARG A  90
LYS A  50
TYR A  52
 None
 1.36A 6gnbA-1x3lA:
2.5		 6gnbA-1x3lA:
24.78