SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		3 / 3 PHE A  33
LEU A  24
SER A 151
 GNP  A 300 (-4.1A)
None
GNP  A 300 (-3.4A)
 0.70A 1e7aA-1x3sA:
undetectable		 1e7aA-1x3sA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		3 / 3 THR A  95
LEU A  99
LEU A 106
 None
 0.64A 1mz9C-1x3sA:
undetectable		 1mz9C-1x3sA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		5 / 12 THR A  40
GLY A  20
GLY A  18
GLY A  66
ASP A 125
 MG  A 200 ( 3.0A)
GNP  A 300 (-3.3A)
GNP  A 300 (-3.5A)
GNP  A 300 (-3.2A)
GNP  A 300 (-2.9A)
 1.01A 2b25A-1x3sA:
undetectable		 2b25A-1x3sA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		5 / 9 VAL A  87
GLY A 121
GLN A  67
ASN A 122
GLY A  20
 None
None
None
GNP  A 300 (-3.2A)
GNP  A 300 (-3.3A)
 1.36A 3kmoA-1x3sA:
undetectable		 3kmoA-1x3sA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		4 / 8 ASN A 122
ALA A 150
SER A 151
LEU A  24
 GNP  A 300 (-3.2A)
None
GNP  A 300 (-3.4A)
None
 1.19A 4ijiF-1x3sA:
undetectable		 4ijiF-1x3sA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		5 / 12 GLY A 157
ASN A 122
ASP A  89
VAL A  90
THR A  91
 None
GNP  A 300 (-3.2A)
None
None
None
 0.84A 5kocA-1x3sA:
undetectable		 5kocA-1x3sA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		5 / 12 GLY A 157
ASN A 122
ASP A  89
VAL A  90
THR A  91
 None
GNP  A 300 (-3.2A)
None
None
None
 0.92A 5kpcB-1x3sA:
undetectable		 5kpcB-1x3sA:
19.49