SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 292
ILE A 284
GLU A 286
ASP A 268
 None
 1.20A 1ditH-1x3wA:
undetectable
1ditP-1x3wA:
undetectable		 1ditH-1x3wA:
22.06
1ditP-1x3wA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA8_0
(GRAMICIDIN C)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 192
VAL A 219
TRP A 194
TRP A 220
 SUC  A1003 (-3.8A)
None
None
None
 1.17A 1nt6A-1x3wA:
undetectable		 1nt6A-1x3wA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB8_0
(GRAMICIDIN C)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 192
VAL A 219
TRP A 194
TRP A 220
 SUC  A1003 (-3.8A)
None
None
None
 1.17A 1nt6B-1x3wA:
undetectable		 1nt6B-1x3wA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 257
PHE A  51
ILE A 284
ARG A 281
 None
 1.22A 1qltA-1x3wA:
0.6		 1qltA-1x3wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 238
TRP A 251
LYS A  94
 SUC  A1001 ( 3.0A)
SUC  A1001 ( 4.3A)
None
 1.27A 1qu2A-1x3wA:
undetectable		 1qu2A-1x3wA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 242
ARG A 230
VAL A 212
TYR A 247
ILE A 246
 None
None
None
None
SUC  A1002 (-4.5A)
 1.37A 1tcoC-1x3wA:
undetectable		 1tcoC-1x3wA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  72
ILE A  74
LEU A  79
 None
 0.73A 2kceA-1x3wA:
undetectable		 2kceA-1x3wA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 297
VAL A 267
ASP A 268
ILE A 259
VAL A 266
 None
 1.49A 2l8mA-1x3wA:
undetectable		 2l8mA-1x3wA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 268
ILE A 274
GLU A 222
ARG A 281
 None
 1.05A 2qqdA-1x3wA:
undetectable
2qqdE-1x3wA:
undetectable		 2qqdA-1x3wA:
11.49
2qqdE-1x3wA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 242
ARG A 230
VAL A 212
TYR A 247
ILE A 246
 None
None
None
None
SUC  A1002 (-4.5A)
 1.38A 2vn1A-1x3wA:
undetectable		 2vn1A-1x3wA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 9 ILE A 259
PHE A  51
ALA A  52
VAL A  55
 None
 0.74A 2vufA-1x3wA:
undetectable		 2vufA-1x3wA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 266
VAL A 267
PHE A 291
ARG A 210
 None
 1.06A 3bjwF-1x3wA:
undetectable		 3bjwF-1x3wA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 266
VAL A 267
PHE A 295
ARG A 210
 None
 0.92A 3bjwF-1x3wA:
undetectable		 3bjwF-1x3wA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 241
PHE A 227
SER A 225
LYS A 110
 None
 1.23A 3hggA-1x3wA:
0.1		 3hggA-1x3wA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 327
ARG A 272
LYS A 110
 None
 1.38A 3okxA-1x3wA:
0.0		 3okxA-1x3wA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 120
GLU A 111
LEU A  79
PHE A 205
 None
 1.16A 3rqwC-1x3wA:
undetectable
3rqwD-1x3wA:
undetectable		 3rqwC-1x3wA:
22.04
3rqwD-1x3wA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 111
LEU A  79
PHE A 205
PHE A 120
 None
 1.14A 3rqwF-1x3wA:
undetectable
3rqwJ-1x3wA:
undetectable		 3rqwF-1x3wA:
22.04
3rqwJ-1x3wA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		5 / 8 GLY A  57
GLY A  54
ILE A 259
LEU A 289
VAL A 266
 None
 1.28A 3v1nA-1x3wA:
undetectable		 3v1nA-1x3wA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 242
ARG A 230
VAL A 212
TYR A 247
ILE A 246
 None
None
None
None
SUC  A1002 (-4.5A)
 1.38A 3vawA-1x3wA:
undetectable		 3vawA-1x3wA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 316
GLY A 265
LEU A 312
GLU A 319
 None
 1.08A 3w9tB-1x3wA:
undetectable		 3w9tB-1x3wA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 316
GLY A 265
LEU A 312
GLU A 319
 None
 1.07A 3w9tE-1x3wA:
undetectable		 3w9tE-1x3wA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 316
GLY A 265
LEU A 312
GLU A 319
 None
 1.05A 3w9tF-1x3wA:
undetectable		 3w9tF-1x3wA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 266
GLN A  60
CYH A  63
 None
 0.77A 5icxA-1x3wA:
undetectable
5icxE-1x3wA:
undetectable		 5icxA-1x3wA:
21.43
5icxE-1x3wA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 5 PRO A 244
LEU A 202
TYR A 211
PHE A 261
 None
 1.46A 5igjA-1x3wA:
undetectable		 5igjA-1x3wA:
18.82