SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 1x40 ARAP2
(Homo
sapiens) 		5 / 12 LEU A  68
LEU A  27
LEU A  52
CYH A  45
VAL A  16
 None
 1.35A 2w8yA-1x40A:
undetectable		 2w8yA-1x40A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1x40 ARAP2
(Homo
sapiens) 		4 / 8 GLU A  13
ASN A  15
MET A  78
LYS A  43
 None
 1.28A 3kp6A-1x40A:
undetectable
3kp6B-1x40A:
undetectable		 3kp6A-1x40A:
21.71
3kp6B-1x40A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1x40 ARAP2
(Homo
sapiens) 		4 / 7 ILE A  56
LEU A  53
LEU A  71
VAL A  16
 None
 0.80A 3r9vA-1x40A:
undetectable
3r9vB-1x40A:
undetectable		 3r9vA-1x40A:
14.69
3r9vB-1x40A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1x40 ARAP2
(Homo
sapiens) 		3 / 3 PHE A  21
SER A  24
GLN A  70
 None
 0.91A 3smtA-1x40A:
undetectable		 3smtA-1x40A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1x40 ARAP2
(Homo
sapiens) 		5 / 9 ILE A  25
LEU A  75
PHE A  21
ILE A  48
ILE A  67
 None
 1.22A 3tq8A-1x40A:
undetectable		 3tq8A-1x40A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1x40 ARAP2
(Homo
sapiens) 		4 / 7 TYR A  30
ILE A  67
ASP A  20
PHE A  34
 None
 0.90A 4iqqA-1x40A:
undetectable		 4iqqA-1x40A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 1x40 ARAP2
(Homo
sapiens) 		5 / 12 ALA A  46
PHE A  34
PHE A  39
THR A  40
LEU A  52
 None
 1.45A 4z7fC-1x40A:
undetectable		 4z7fC-1x40A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1x40 ARAP2
(Homo
sapiens) 		5 / 11 ILE A  18
GLN A  29
LEU A  27
LEU A  31
LEU A  71
 None
 1.22A 5ji0A-1x40A:
undetectable		 5ji0A-1x40A:
17.84