SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		4 / 4 SER A  93
GLU A  78
SER A  88
ASP A  16
 None
 1.50A 1h1dA-1x44A:
undetectable		 1h1dA-1x44A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		5 / 12 ALA A  36
ASP A  35
ASP A  34
ILE A  57
VAL A  31
 None
 0.96A 1k6cB-1x44A:
undetectable		 1k6cB-1x44A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		4 / 8 THR A  84
GLY A  86
ILE A   8
VAL A  10
 None
 0.96A 1rxcB-1x44A:
undetectable		 1rxcB-1x44A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		4 / 8 THR A  84
GLY A  86
ILE A   8
VAL A  10
 None
 0.98A 1rxcE-1x44A:
undetectable		 1rxcE-1x44A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		4 / 8 THR A  84
GLY A  86
ILE A   8
VAL A  10
 None
 0.96A 1rxcI-1x44A:
undetectable		 1rxcI-1x44A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		4 / 8 THR A  84
GLY A  86
ILE A   8
VAL A  10
 None
 0.92A 1rxcK-1x44A:
undetectable		 1rxcK-1x44A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		4 / 5 SER A  93
GLU A  78
SER A  88
ASP A  16
 None
 1.46A 1vidA-1x44A:
undetectable		 1vidA-1x44A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		5 / 12 ALA A  36
ASP A  35
ASP A  34
ILE A  57
VAL A  31
 None
 0.96A 2b7zA-1x44A:
undetectable		 2b7zA-1x44A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		5 / 12 ALA A  36
ASP A  35
ASP A  34
ILE A  57
VAL A  31
 None
 0.99A 2b7zB-1x44A:
undetectable		 2b7zB-1x44A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		5 / 9 ASP A  95
GLY A  22
GLU A  23
ALA A  71
THR A  18
 None
 1.29A 2dtjA-1x44A:
undetectable
2dtjB-1x44A:
undetectable		 2dtjA-1x44A:
23.46
2dtjB-1x44A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		6 / 11 ALA A  36
ASP A  35
ASP A  34
ILE A  65
THR A  11
VAL A  10
 None
 1.24A 2nnpA-1x44A:
undetectable		 2nnpA-1x44A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		3 / 3 MET A  82
VAL A  59
GLU A  33
 None
 0.66A 2x9gA-1x44A:
undetectable		 2x9gA-1x44A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		4 / 8 THR A  84
GLY A  86
ILE A   8
VAL A  10
 None
 0.96A 4e1vA-1x44A:
undetectable		 4e1vA-1x44A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		4 / 8 THR A  84
GLY A  86
ILE A   8
VAL A  10
 None
 0.98A 4e1vD-1x44A:
undetectable		 4e1vD-1x44A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		5 / 11 ALA A  36
ASP A  35
ASP A  34
ILE A  65
THR A  11
 None
 0.96A 4l1aA-1x44A:
undetectable		 4l1aA-1x44A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		5 / 12 ILE A  68
ALA A  77
THR A  83
VAL A  38
LEU A  66
 None
 1.31A 4qynA-1x44A:
undetectable		 4qynA-1x44A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE
(Homo
sapiens) 		4 / 5 SER A  93
GLU A  78
SER A  88
ASP A  16
 None
 1.49A 5fhrA-1x44A:
0.0		 5fhrA-1x44A:
17.92