SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACB_C_DXCC1475_0 (TRANSLATION ELONGATION FACTOR SELB)	1x4b	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2/B1 (Homo sapiens)	4 / 8	ILE A 93 ASP A 94 VAL A 74 GLY A 72	None	0.81A	4acbC-1x4bA: undetectable	4acbC-1x4bA: 12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L78_A_ACTA1327_0 (PHOSPHORIBOSYLFORMYL GLYCINAMIDINE SYNTHASE)	1x4b	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2/B1 (Homo sapiens)	4 / 4	VAL A 59 THR A 40 GLU A 41 GLU A 42	None	1.41A	4l78A-1x4bA: 0.0	4l78A-1x4bA: 6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O8F_B_BRLB501_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	1x4b	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2/B1 (Homo sapiens)	4 / 6	ILE A 32 PHE A 71 GLY A 34 ILE A 93	None	0.67A	4o8fB-1x4bA: undetectable	4o8fB-1x4bA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_C7HA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1x4b	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2/B1 (Homo sapiens)	4 / 5	TYR A 48 GLY A 33 TYR A 47 GLY A 95	None	0.93A	5ayfA-1x4bA: undetectable	5ayfA-1x4bA: 21.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4ACB_C_DXCC1475_0","TRANSLATION ELONGATION FACTOR SELB","1x4b","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2\/B1","Homo sapiens",4,"ILE A  93;ASP A  94;VAL A  74;GLY A  72","None","0.81A","4acbC-1x4bA:undetectable","4acbC-1x4bA:12.83"],["4L78_A_ACTA1327_0","PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE","1x4b","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2\/B1","Homo sapiens",4,"VAL A  59;THR A  40;GLU A  41;GLU A  42","None","1.41A","4l78A-1x4bA:0.0","4l78A-1x4bA:6.29"],["4O8F_B_BRLB501_2","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","1x4b","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2\/B1","Homo sapiens",4,"ILE A  32;PHE A  71;GLY A  34;ILE A  93","None","0.67A","4o8fB-1x4bA:undetectable","4o8fB-1x4bA:19.35"],["5AYF_A_C7HA402_1","HISTONE-LYSINE N-METHYLTRANSFERASE SETD7","1x4b","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2\/B1","Homo sapiens",4,"TYR A  48;GLY A  33;TYR A  47;GLY A  95","None","0.93A","5ayfA-1x4bA:undetectable","5ayfA-1x4bA:21.11"]]