SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 1x4g NUCLEOLYSIN TIAR
(Homo
sapiens) 		4 / 5 CYH A  93
TYR A  63
THR A  84
THR A  27
 None
 1.41A 3q07A-1x4gA:
undetectable		 3q07A-1x4gA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 1x4g NUCLEOLYSIN TIAR
(Homo
sapiens) 		4 / 5 CYH A  93
TYR A  63
THR A  84
THR A  27
 None
 1.39A 3q07B-1x4gA:
undetectable		 3q07B-1x4gA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 1x4g NUCLEOLYSIN TIAR
(Homo
sapiens) 		4 / 6 MET A  53
ILE A  33
ILE A  86
VAL A  91
 None
 0.90A 4olmA-1x4gA:
undetectable		 4olmA-1x4gA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1x4g NUCLEOLYSIN TIAR
(Homo
sapiens) 		4 / 8 GLU A  72
PHE A  49
GLY A  50
PHE A  14
 None
 0.95A 5flcB-1x4gA:
0.0		 5flcB-1x4gA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1x4g NUCLEOLYSIN TIAR
(Homo
sapiens) 		4 / 8 GLU A  72
PHE A  49
GLY A  50
PHE A  14
 None
 0.95A 5flcF-1x4gA:
0.0		 5flcF-1x4gA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1x4g NUCLEOLYSIN TIAR
(Homo
sapiens) 		4 / 7 ILE A  78
GLU A  72
HIS A  71
VAL A  17
 None
 1.19A 6j20A-1x4gA:
undetectable		 6j20A-1x4gA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1x4g NUCLEOLYSIN TIAR
(Homo
sapiens) 		4 / 5 THR A  27
HIS A  71
SER A  22
SER A  21
 None
 0.94A 6jmjA-1x4gA:
undetectable		 6jmjA-1x4gA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1x4g NUCLEOLYSIN TIAR
(Homo
sapiens) 		4 / 7 THR A  27
HIS A  71
SER A  22
SER A  21
 None
 0.93A 6jnhA-1x4gA:
undetectable		 6jnhA-1x4gA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1x4g NUCLEOLYSIN TIAR
(Homo
sapiens) 		4 / 6 THR A  27
HIS A  71
SER A  22
SER A  21
 None
 0.93A 6jogA-1x4gA:
undetectable		 6jogA-1x4gA:
21.91