SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1x4s ZINC FINGER HIT
DOMAIN CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 TYR A  53
THR A  47
CYH A  29
TYR A  42
 None
None
ZN  A 401 (-2.3A)
None
 1.39A 1uw6A-1x4sA:
undetectable
1uw6B-1x4sA:
undetectable		 1uw6A-1x4sA:
12.38
1uw6B-1x4sA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1x4s ZINC FINGER HIT
DOMAIN CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 TYR A  53
THR A  47
CYH A  29
TYR A  42
 None
None
ZN  A 401 (-2.3A)
None
 1.40A 1uw6D-1x4sA:
undetectable
1uw6E-1x4sA:
undetectable		 1uw6D-1x4sA:
12.38
1uw6E-1x4sA:
12.38