SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HZ4_A_BEZA784_0 (MALT REGULATORY PROTEIN)	1x51	A/G-SPECIFIC ADENINE DNA GLYCOSYLASE (Homo sapiens)	4 / 6	HIS A 84 LEU A 70 LEU A 80 PRO A 79	None	1.10A	1hz4A-1x51A: undetectable	1hz4A-1x51A: 16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO5_B_CHDB503_0 (FERROCHELATASE, MITOCHONDRIAL)	1x51	A/G-SPECIFIC ADENINE DNA GLYCOSYLASE (Homo sapiens)	3 / 3	LEU A 80 PRO A 81 LEU A 70	None	0.62A	2po5B-1x51A: undetectable	2po5B-1x51A: 17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WW7_A_ACTA303_0 (EKC/KEOPS COMPLEX SUBUNIT BUD32)	1x51	A/G-SPECIFIC ADENINE DNA GLYCOSYLASE (Homo sapiens)	4 / 4	LEU A 38 VAL A 39 GLU A 52 ARG A 41	None	1.21A	4ww7A-1x51A: 0.0	4ww7A-1x51A: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGG_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	1x51	A/G-SPECIFIC ADENINE DNA GLYCOSYLASE (Homo sapiens)	4 / 4	VAL A 142 VAL A 91 TYR A 102 GLN A 103	None	1.42A	5qggA-1x51A: 8.9	5qggA-1x51A: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGO_A_ACTA302_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	1x51	A/G-SPECIFIC ADENINE DNA GLYCOSYLASE (Homo sapiens)	4 / 4	VAL A 142 VAL A 91 TYR A 102 GLN A 103	None	1.46A	5qgoA-1x51A: 9.0	5qgoA-1x51A: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGP_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	1x51	A/G-SPECIFIC ADENINE DNA GLYCOSYLASE (Homo sapiens)	4 / 4	VAL A 142 VAL A 91 TYR A 102 GLN A 103	None	1.41A	5qgpA-1x51A: 8.9	5qgpA-1x51A: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGQ_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	1x51	A/G-SPECIFIC ADENINE DNA GLYCOSYLASE (Homo sapiens)	4 / 4	VAL A 142 VAL A 91 TYR A 102 GLN A 103	None	1.39A	5qgqA-1x51A: 9.0	5qgqA-1x51A: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QHB_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	1x51	A/G-SPECIFIC ADENINE DNA GLYCOSYLASE (Homo sapiens)	4 / 4	VAL A 142 VAL A 91 TYR A 102 GLN A 103	None	1.42A	5qhbA-1x51A: 9.0	5qhbA-1x51A: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUD_D_ERMD1201_2 (5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA)	1x51	A/G-SPECIFIC ADENINE DNA GLYCOSYLASE (Homo sapiens)	4 / 6	LEU A 73 LEU A 26 LEU A 125 GLU A 52	None	0.88A	5tudD-1x51A: undetectable	5tudD-1x51A: 15.30

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HZ4_A_BEZA784_0","MALT REGULATORY PROTEIN","1x51","A\/G-SPECIFIC ADENINE DNA GLYCOSYLASE","Homo sapiens",4,"HIS A  84;LEU A  70;LEU A  80;PRO A  79","None","1.10A","1hz4A-1x51A:undetectable","1hz4A-1x51A:16.22"],["2PO5_B_CHDB503_0","FERROCHELATASE, MITOCHONDRIAL","1x51","A\/G-SPECIFIC ADENINE DNA GLYCOSYLASE","Homo sapiens",3,"LEU A  80;PRO A  81;LEU A  70","None","0.62A","2po5B-1x51A:undetectable","2po5B-1x51A:17.10"],["4WW7_A_ACTA303_0","EKC\/KEOPS COMPLEX SUBUNIT BUD32","1x51","A\/G-SPECIFIC ADENINE DNA GLYCOSYLASE","Homo sapiens",4,"LEU A  38;VAL A  39;GLU A  52;ARG A  41","None","1.21A","4ww7A-1x51A:0.0","4ww7A-1x51A:21.13"],["5QGG_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","1x51","A\/G-SPECIFIC ADENINE DNA GLYCOSYLASE","Homo sapiens",4,"VAL A 142;VAL A  91;TYR A 102;GLN A 103","None","1.42A","5qggA-1x51A:8.9","5qggA-1x51A:21.53"],["5QGO_A_ACTA302_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","1x51","A\/G-SPECIFIC ADENINE DNA GLYCOSYLASE","Homo sapiens",4,"VAL A 142;VAL A  91;TYR A 102;GLN A 103","None","1.46A","5qgoA-1x51A:9.0","5qgoA-1x51A:21.53"],["5QGP_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","1x51","A\/G-SPECIFIC ADENINE DNA GLYCOSYLASE","Homo sapiens",4,"VAL A 142;VAL A  91;TYR A 102;GLN A 103","None","1.41A","5qgpA-1x51A:8.9","5qgpA-1x51A:21.53"],["5QGQ_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","1x51","A\/G-SPECIFIC ADENINE DNA GLYCOSYLASE","Homo sapiens",4,"VAL A 142;VAL A  91;TYR A 102;GLN A 103","None","1.39A","5qgqA-1x51A:9.0","5qgqA-1x51A:21.53"],["5QHB_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","1x51","A\/G-SPECIFIC ADENINE DNA GLYCOSYLASE","Homo sapiens",4,"VAL A 142;VAL A  91;TYR A 102;GLN A 103","None","1.42A","5qhbA-1x51A:9.0","5qhbA-1x51A:21.53"],["5TUD_D_ERMD1201_2","5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA","1x51","A\/G-SPECIFIC ADENINE DNA GLYCOSYLASE","Homo sapiens",4,"LEU A  73;LEU A  26;LEU A 125;GLU A  52","None","0.88A","5tudD-1x51A:undetectable","5tudD-1x51A:15.30"]]