SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 1x5c PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A   9
VAL A  61
TRP A  47
 None
 0.93A 1w5uA-1x5cA:
undetectable
1w5uB-1x5cA:
undetectable		 1w5uA-1x5cA:
10.96
1w5uB-1x5cA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 1x5c PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A  61
TRP A  47
VAL A   9
 None
 0.97A 2izqC-1x5cA:
undetectable
2izqD-1x5cA:
undetectable		 2izqC-1x5cA:
10.96
2izqD-1x5cA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1x5c PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 12 LEU A  43
LEU A  83
ILE A  62
TYR A  54
PHE A 106
 None
 1.10A 2weyA-1x5cA:
undetectable		 2weyA-1x5cA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1x5c PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A  28
ALA A  88
PHE A  85
 None
 0.77A 4olbA-1x5cA:
undetectable		 4olbA-1x5cA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1x5c PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		4 / 8 THR A 102
TYR A  97
TRP A  47
LEU A  50
 None
 1.22A 5kxiA-1x5cA:
undetectable
5kxiB-1x5cA:
undetectable		 5kxiA-1x5cA:
16.58
5kxiB-1x5cA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1x5c PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		4 / 8 THR A 102
TYR A  97
TRP A  47
LEU A  50
 None
 1.20A 5kxiD-1x5cA:
undetectable
5kxiE-1x5cA:
undetectable		 5kxiD-1x5cA:
16.58
5kxiE-1x5cA:
14.11