SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DMA_A_NCAA700_0 (EXOTOXIN A)	1x5d	PROTEIN DISULFIDE-ISOMERASE A6 (Homo sapiens)	4 / 7	GLY A 80 LEU A 75 ALA A 76 TYR A 79	None	0.91A	1dmaA-1x5dA: undetectable	1dmaA-1x5dA: 23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_A_HSMA1161_1 (ALLERGEN ARG R 1)	1x5d	PROTEIN DISULFIDE-ISOMERASE A6 (Homo sapiens)	4 / 5	VAL A 30 VAL A 21 ASP A 18 SER A 16	None	1.27A	2x45A-1x5dA: undetectable	2x45A-1x5dA: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EJJ_B_NCTB501_1 (CYTOCHROME P450 2A6)	1x5d	PROTEIN DISULFIDE-ISOMERASE A6 (Homo sapiens)	4 / 7	PHE A 17 VAL A 67 ASN A 72 PHE A 90	None	0.98A	4ejjB-1x5dA: undetectable	4ejjB-1x5dA: 14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KTT_A_SAMA405_1 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)	1x5d	PROTEIN DISULFIDE-ISOMERASE A6 (Homo sapiens)	4 / 8	ALA A 48 ASP A 107 ILE A 108 ILE A 87	None	0.84A	4kttB-1x5dA: undetectable	4kttB-1x5dA: 17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KTT_C_SAMC404_1 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)	1x5d	PROTEIN DISULFIDE-ISOMERASE A6 (Homo sapiens)	4 / 8	ALA A 48 ASP A 107 ILE A 108 ILE A 87	None	0.81A	4kttD-1x5dA: undetectable	4kttD-1x5dA: 17.23

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DMA_A_NCAA700_0","EXOTOXIN A","1x5d","PROTEIN DISULFIDE-ISOMERASE A6","Homo sapiens",4,"GLY A  80;LEU A  75;ALA A  76;TYR A  79","None","0.91A","1dmaA-1x5dA:undetectable","1dmaA-1x5dA:23.29"],["2X45_A_HSMA1161_1","ALLERGEN ARG R 1","1x5d","PROTEIN DISULFIDE-ISOMERASE A6","Homo sapiens",4,"VAL A  30;VAL A  21;ASP A  18;SER A  16","None","1.27A","2x45A-1x5dA:undetectable","2x45A-1x5dA:20.50"],["4EJJ_B_NCTB501_1","CYTOCHROME P450 2A6","1x5d","PROTEIN DISULFIDE-ISOMERASE A6","Homo sapiens",4,"PHE A  17;VAL A  67;ASN A  72;PHE A  90","None","0.98A","4ejjB-1x5dA:undetectable","4ejjB-1x5dA:14.22"],["4KTT_A_SAMA405_1","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","1x5d","PROTEIN DISULFIDE-ISOMERASE A6","Homo sapiens",4,"ALA A  48;ASP A 107;ILE A 108;ILE A  87","None","0.84A","4kttB-1x5dA:undetectable","4kttB-1x5dA:17.23"],["4KTT_C_SAMC404_1","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","1x5d","PROTEIN DISULFIDE-ISOMERASE A6","Homo sapiens",4,"ALA A  48;ASP A 107;ILE A 108;ILE A  87","None","0.81A","4kttD-1x5dA:undetectable","4kttD-1x5dA:17.23"]]