SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1x5h NEOGENIN
(Homo
sapiens) 		4 / 5 HIS A  38
SER A  26
GLU A  28
ASP A 119
 None
 1.40A 3tm4A-1x5hA:
undetectable		 3tm4A-1x5hA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1x5h NEOGENIN
(Homo
sapiens) 		5 / 12 TRP A  39
VAL A  94
ALA A 111
ILE A  81
LEU A  84
 None
 1.16A 3w67C-1x5hA:
undetectable		 3w67C-1x5hA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 1x5h NEOGENIN
(Homo
sapiens) 		3 / 3 LYS A  64
ARG A  59
TRP A 108
 None
 1.31A 4i90A-1x5hA:
undetectable		 4i90A-1x5hA:
19.13