SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UT5_B_LOCB502_1 (TUBULIN BETA CHAIN)	1x5n	HARMONIN (Homo sapiens)	5 / 12	CYH A 31 LEU A 29 LEU A 85 ILE A 45 ILE A 65	None	1.13A	3ut5B-1x5nA: undetectable	3ut5B-1x5nA: 15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JQ1_B_NPSB401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	1x5n	HARMONIN (Homo sapiens)	4 / 8	VAL A 57 VAL A 19 ILE A 93 LEU A 23	None	0.93A	4jq1B-1x5nA: undetectable	4jq1B-1x5nA: 18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L1W_B_STRB402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	1x5n	HARMONIN (Homo sapiens)	4 / 6	VAL A 57 VAL A 19 ILE A 93 LEU A 23	None	0.85A	4l1wB-1x5nA: undetectable	4l1wB-1x5nA: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XV2_B_P06B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1x5n	HARMONIN (Homo sapiens)	4 / 4	GLY A 100 VAL A 96 PHE A 73 ILE A 65	None	1.03A	4xv2B-1x5nA: undetectable	4xv2B-1x5nA: 17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HLP_A_GAWA1501_0 (SUBSTANCE-P RECEPTOR,SUBSTANCE-P RECEPTOR)	1x5n	HARMONIN (Homo sapiens)	5 / 12	ILE A 95 ILE A 65 VAL A 19 THR A 92 ILE A 93	None	1.16A	6hlpA-1x5nA: undetectable	6hlpA-1x5nA: 12.45

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3UT5_B_LOCB502_1","TUBULIN BETA CHAIN","1x5n","HARMONIN","Homo sapiens",5,"CYH A  31;LEU A  29;LEU A  85;ILE A  45;ILE A  65","None","1.13A","3ut5B-1x5nA:undetectable","3ut5B-1x5nA:15.05"],["4JQ1_B_NPSB401_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2","1x5n","HARMONIN","Homo sapiens",4,"VAL A  57;VAL A  19;ILE A  93;LEU A  23","None","0.93A","4jq1B-1x5nA:undetectable","4jq1B-1x5nA:18.07"],["4L1W_B_STRB402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2","1x5n","HARMONIN","Homo sapiens",4,"VAL A  57;VAL A  19;ILE A  93;LEU A  23","None","0.85A","4l1wB-1x5nA:undetectable","4l1wB-1x5nA:17.65"],["4XV2_B_P06B801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","1x5n","HARMONIN","Homo sapiens",4,"GLY A 100;VAL A  96;PHE A  73;ILE A  65","None","1.03A","4xv2B-1x5nA:undetectable","4xv2B-1x5nA:17.69"],["6HLP_A_GAWA1501_0","SUBSTANCE-P RECEPTOR,SUBSTANCE-P RECEPTOR","1x5n","HARMONIN","Homo sapiens",5,"ILE A  95;ILE A  65;VAL A  19;THR A  92;ILE A  93","None","1.16A","6hlpA-1x5nA:undetectable","6hlpA-1x5nA:12.45"]]