SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1x5q LAP4 PROTEIN
(Homo
sapiens) 		4 / 7 SER A 108
GLU A  14
GLU A 104
GLU A  13
 None
 1.21A 1knyA-1x5qA:
undetectable
1knyB-1x5qA:
undetectable		 1knyA-1x5qA:
21.36
1knyB-1x5qA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 1x5q LAP4 PROTEIN
(Homo
sapiens) 		5 / 11 LEU A  28
GLY A  29
ILE A  30
SER A  31
ILE A  32
 None
 0.72A 2kawA-1x5qA:
9.6		 2kawA-1x5qA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1x5q LAP4 PROTEIN
(Homo
sapiens) 		5 / 11 GLN A  24
ALA A  93
GLY A  94
THR A  95
ALA A  96
 None
 1.26A 3mg0H-1x5qA:
undetectable
3mg0I-1x5qA:
undetectable		 3mg0H-1x5qA:
18.87
3mg0I-1x5qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1x5q LAP4 PROTEIN
(Homo
sapiens) 		5 / 12 GLN A  24
ALA A  93
GLY A  94
THR A  95
ALA A  96
 None
 1.22A 5l5fH-1x5qA:
undetectable
5l5fI-1x5qA:
undetectable		 5l5fH-1x5qA:
18.87
5l5fI-1x5qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1x5q LAP4 PROTEIN
(Homo
sapiens) 		5 / 12 GLN A  24
ALA A  93
GLY A  94
THR A  95
ALA A  96
 None
 1.22A 5l5fV-1x5qA:
undetectable
5l5fW-1x5qA:
undetectable		 5l5fV-1x5qA:
18.87
5l5fW-1x5qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1x5q LAP4 PROTEIN
(Homo
sapiens) 		5 / 12 GLN A  24
ALA A  93
GLY A  94
THR A  95
ALA A  96
 None
 1.23A 5l66H-1x5qA:
undetectable
5l66I-1x5qA:
undetectable		 5l66H-1x5qA:
18.87
5l66I-1x5qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1x5q LAP4 PROTEIN
(Homo
sapiens) 		5 / 12 GLN A  24
ALA A  93
GLY A  94
THR A  95
ALA A  96
 None
 1.24A 5l66V-1x5qA:
undetectable
5l66W-1x5qA:
undetectable		 5l66V-1x5qA:
18.87
5l66W-1x5qA:
20.00