SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		3 / 3 GLU A  15
THR A  14
LEU A  71
 None
 0.65A 1v8bC-1x5rA:
undetectable		 1v8bC-1x5rA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		4 / 5 LEU A 101
PRO A  47
VAL A  70
ILE A  73
 None
 1.02A 2aoiB-1x5rA:
undetectable		 2aoiB-1x5rA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		4 / 6 ILE A  52
VAL A  49
LEU A  33
LEU A  90
 None
 0.84A 3kp6A-1x5rA:
undetectable
3kp6B-1x5rA:
undetectable		 3kp6A-1x5rA:
23.75
3kp6B-1x5rA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		4 / 5 GLU A  79
THR A  78
GLU A 102
THR A  17
 None
 1.17A 5hm8A-1x5rA:
undetectable		 5hm8A-1x5rA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		4 / 5 GLU A  79
THR A  78
GLU A 102
THR A  17
 None
 1.17A 5hm8B-1x5rA:
undetectable		 5hm8B-1x5rA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		4 / 5 GLU A  79
THR A  78
GLU A 102
THR A  17
 None
 1.17A 5hm8C-1x5rA:
undetectable		 5hm8C-1x5rA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		4 / 5 GLU A  79
THR A  78
GLU A 102
THR A  17
 None
 1.17A 5hm8D-1x5rA:
undetectable		 5hm8D-1x5rA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		4 / 5 GLU A  79
THR A  78
GLU A 102
THR A  17
 None
 1.17A 5hm8E-1x5rA:
undetectable		 5hm8E-1x5rA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		4 / 5 GLU A  79
THR A  78
GLU A 102
THR A  17
 None
 1.17A 5hm8F-1x5rA:
undetectable		 5hm8F-1x5rA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		4 / 5 GLU A  79
THR A  78
GLU A 102
THR A  17
 None
 1.19A 5hm8G-1x5rA:
undetectable		 5hm8G-1x5rA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		4 / 5 GLU A  79
THR A  78
GLU A 102
THR A  17
 None
 1.17A 5hm8H-1x5rA:
undetectable		 5hm8H-1x5rA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		3 / 3 VAL A  66
VAL A  49
GLN A  32
 None
 0.70A 5qgvA-1x5rA:
undetectable		 5qgvA-1x5rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		3 / 3 VAL A  66
VAL A  49
GLN A  32
 None
 0.70A 5qgwA-1x5rA:
undetectable		 5qgwA-1x5rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		3 / 3 VAL A  66
VAL A  49
GLN A  32
 None
 0.70A 5qgxA-1x5rA:
undetectable		 5qgxA-1x5rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		3 / 3 VAL A  66
VAL A  49
GLN A  32
 None
 0.69A 5qh1A-1x5rA:
undetectable		 5qh1A-1x5rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		3 / 3 VAL A  66
VAL A  49
GLN A  32
 None
 0.69A 5qhfA-1x5rA:
undetectable		 5qhfA-1x5rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens) 		5 / 12 VAL A  70
SER A  72
THR A  78
ALA A  86
VAL A 100
 None
 1.33A 6drxA-1x5rA:
undetectable		 6drxA-1x5rA:
14.36