SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7X_A_CFFA864_1 (GLYCOGEN PHOSPHORYLASE, LIVER FORM)	1x6g	MEGAKARYOCYTE-ASSOCI ATED TYROSINE-PROTEIN KINASE (Homo sapiens)	3 / 3	TRP A 53 HIS A 26 LYS A 30	None	1.45A	1l7xA-1x6gA: undetectable	1l7xA-1x6gA: 7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TWP_C_SALC404_1 (ANTHRANILATE PHOSPHORIBOSYLTRANSF ERASE)	1x6g	MEGAKARYOCYTE-ASSOCI ATED TYROSINE-PROTEIN KINASE (Homo sapiens)	4 / 7	ALA A 15 PRO A 16 TYR A 54 ARG A 55	None	1.01A	3twpC-1x6gA: undetectable	3twpC-1x6gA: 13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_A_ACTA803_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1x6g	MEGAKARYOCYTE-ASSOCI ATED TYROSINE-PROTEIN KINASE (Homo sapiens)	4 / 4	GLU A 46 PRO A 16 ILE A 44 LEU A 45	None	1.03A	5m45A-1x6gA: undetectable	5m45A-1x6gA: 10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_D_ACTD803_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1x6g	MEGAKARYOCYTE-ASSOCI ATED TYROSINE-PROTEIN KINASE (Homo sapiens)	4 / 4	GLU A 46 PRO A 16 ILE A 44 LEU A 45	None	1.08A	5m45D-1x6gA: undetectable	5m45D-1x6gA: 10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_G_ACTG803_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1x6g	MEGAKARYOCYTE-ASSOCI ATED TYROSINE-PROTEIN KINASE (Homo sapiens)	4 / 4	GLU A 46 PRO A 16 ILE A 44 LEU A 45	None	1.02A	5m45G-1x6gA: undetectable	5m45G-1x6gA: 10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_J_ACTJ803_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1x6g	MEGAKARYOCYTE-ASSOCI ATED TYROSINE-PROTEIN KINASE (Homo sapiens)	4 / 4	GLU A 46 PRO A 16 ILE A 44 LEU A 45	None	1.05A	5m45J-1x6gA: undetectable	5m45J-1x6gA: 10.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1L7X_A_CFFA864_1","GLYCOGEN PHOSPHORYLASE, LIVER FORM","1x6g","MEGAKARYOCYTE-ASSOCIATED TYROSINE-PROTEIN KINASE","Homo sapiens",3,"TRP A  53;HIS A  26;LYS A  30","None","1.45A","1l7xA-1x6gA:undetectable","1l7xA-1x6gA:7.12"],["3TWP_C_SALC404_1","ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE","1x6g","MEGAKARYOCYTE-ASSOCIATED TYROSINE-PROTEIN KINASE","Homo sapiens",4,"ALA A  15;PRO A  16;TYR A  54;ARG A  55","None","1.01A","3twpC-1x6gA:undetectable","3twpC-1x6gA:13.65"],["5M45_A_ACTA803_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1x6g","MEGAKARYOCYTE-ASSOCIATED TYROSINE-PROTEIN KINASE","Homo sapiens",4,"GLU A  46;PRO A  16;ILE A  44;LEU A  45","None","1.03A","5m45A-1x6gA:undetectable","5m45A-1x6gA:10.41"],["5M45_D_ACTD803_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1x6g","MEGAKARYOCYTE-ASSOCIATED TYROSINE-PROTEIN KINASE","Homo sapiens",4,"GLU A  46;PRO A  16;ILE A  44;LEU A  45","None","1.08A","5m45D-1x6gA:undetectable","5m45D-1x6gA:10.41"],["5M45_G_ACTG803_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1x6g","MEGAKARYOCYTE-ASSOCIATED TYROSINE-PROTEIN KINASE","Homo sapiens",4,"GLU A  46;PRO A  16;ILE A  44;LEU A  45","None","1.02A","5m45G-1x6gA:undetectable","5m45G-1x6gA:10.41"],["5M45_J_ACTJ803_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1x6g","MEGAKARYOCYTE-ASSOCIATED TYROSINE-PROTEIN KINASE","Homo sapiens",4,"GLU A  46;PRO A  16;ILE A  44;LEU A  45","None","1.05A","5m45J-1x6gA:undetectable","5m45J-1x6gA:10.41"]]