SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME
(Paracoccus
denitrificans) 		4 / 6 ALA A 142
TYR A 172
MET A 180
HIS A  52
 None
 1.49A 2pncB-1x6mA:
undetectable		 2pncB-1x6mA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME
(Paracoccus
denitrificans) 		5 / 10 ILE A  96
LEU A  78
VAL A  73
VAL A  44
LEU A  31
 SO4  A 501 (-4.2A)
None
None
None
None
 1.06A 3gwxA-1x6mA:
undetectable		 3gwxA-1x6mA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME
(Paracoccus
denitrificans) 		3 / 3 GLU A 166
HIS A   2
THR A   6
 None
 0.89A 3hkuA-1x6mA:
undetectable		 3hkuA-1x6mA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME
(Paracoccus
denitrificans) 		4 / 8 GLU A 149
SER A 150
ARG A 161
VAL A 152
 None
 1.33A 3jx1A-1x6mA:
undetectable
3jx1B-1x6mA:
undetectable		 3jx1A-1x6mA:
18.85
3jx1B-1x6mA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME
(Paracoccus
denitrificans) 		4 / 8 GLU A 149
SER A 150
ARG A 161
VAL A 152
 None
 1.36A 3nlyA-1x6mA:
undetectable
3nlyB-1x6mA:
undetectable		 3nlyA-1x6mA:
18.85
3nlyB-1x6mA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME
(Paracoccus
denitrificans) 		4 / 8 GLU A 149
SER A 150
ARG A 161
VAL A 152
 None
 1.36A 3rqlA-1x6mA:
undetectable
3rqlB-1x6mA:
undetectable		 3rqlA-1x6mA:
18.85
3rqlB-1x6mA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME
(Paracoccus
denitrificans) 		4 / 8 GLU A 149
SER A 150
ARG A 161
VAL A 152
 None
 1.37A 4capA-1x6mA:
undetectable
4capB-1x6mA:
undetectable		 4capA-1x6mA:
18.85
4capB-1x6mA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME
(Paracoccus
denitrificans) 		4 / 8 GLU A 149
SER A 150
ARG A 161
VAL A 152
 None
 1.36A 4d32A-1x6mA:
undetectable
4d32B-1x6mA:
undetectable		 4d32A-1x6mA:
18.85
4d32B-1x6mA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME
(Paracoccus
denitrificans) 		3 / 3 TYR A 109
HIS A  99
ARG A 111
 None
 1.06A 4e7bC-1x6mA:
undetectable		 4e7bC-1x6mA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME
(Paracoccus
denitrificans) 		4 / 8 GLU A 149
SER A 150
ARG A 161
VAL A 152
 None
 1.36A 4v3yA-1x6mA:
undetectable
4v3yB-1x6mA:
undetectable		 4v3yA-1x6mA:
18.85
4v3yB-1x6mA:
18.85