SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  70
ALA A  42
LEU A  91
ILE A 113
LEU A 134
 None
 1.06A 1ddsB-1x77A:
2.6		 1ddsB-1x77A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  70
ALA A  42
LEU A  91
ILE A 113
LEU A 134
 None
 1.11A 1dyiB-1x77A:
2.5		 1dyiB-1x77A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  70
ALA A  42
LEU A  91
ILE A 113
LEU A 134
 None
 1.17A 1rx3A-1x77A:
2.8		 1rx3A-1x77A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  79
ALA A 112
LEU A 142
LEU A 178
LEU A  91
 None
 0.95A 2bxqA-1x77A:
undetectable		 2bxqA-1x77A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  47
PRO A  81
GLY A  89
MET A  87
 None
FMN  A 200 (-3.9A)
None
None
 1.06A 2pnjB-1x77A:
3.9		 2pnjB-1x77A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 156
LEU A 114
ALA A 167
ALA A 152
 None
None
None
FMN  A 200 ( 4.8A)
 0.81A 2vcvB-1x77A:
undetectable		 2vcvB-1x77A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  10
LEU A  76
LEU A  91
ALA A  94
 None
 0.77A 2vcvF-1x77A:
undetectable		 2vcvF-1x77A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 9 PHE A  66
LEU A  76
LEU A 130
LEU A  91
ALA A  94
 None
 1.24A 2vcvI-1x77A:
undetectable		 2vcvI-1x77A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 156
LEU A 114
ALA A 167
ALA A 152
 None
None
None
FMN  A 200 ( 4.8A)
 0.83A 2vcvK-1x77A:
undetectable		 2vcvK-1x77A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 170
ALA A  25
LEU A 162
ALA A 155
 None
 0.84A 2vcvP-1x77A:
undetectable		 2vcvP-1x77A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 134
VAL A 139
ILE A  70
PHE A  66
PHE A  78
 None
 1.24A 2weyA-1x77A:
undetectable		 2weyA-1x77A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 8 LEU A  91
VAL A 139
ILE A  70
PHE A  66
PHE A  78
 None
 1.44A 2weyB-1x77A:
undetectable		 2weyB-1x77A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 174
ALA A 112
ILE A 113
ARG A 131
 None
 1.47A 2z0aA-1x77A:
undetectable		 2z0aA-1x77A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 116
LEU A  26
GLN A  27
LEU A 175
VAL A 147
 FMN  A 200 ( 4.6A)
None
None
None
None
 1.18A 3ix9A-1x77A:
undetectable		 3ix9A-1x77A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 131
ASP A  96
GLY A  89
THR A  80
 None
 1.22A 3k4vB-1x77A:
undetectable		 3k4vB-1x77A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 106
ALA A  98
ALA A  94
MET A  87
 None
 0.85A 3l4dA-1x77A:
undetectable		 3l4dA-1x77A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  70
ALA A  42
LEU A  91
ILE A 113
LEU A 134
 None
 1.18A 3ql0A-1x77A:
2.7		 3ql0A-1x77A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 122
GLY A 115
ILE A 149
LEU A 114
 None
 0.77A 4mwzB-1x77A:
1.0		 4mwzB-1x77A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  91
THR A 133
LEU A 134
LEU A 130
 None
 0.77A 4z90F-1x77A:
0.0
4z90G-1x77A:
0.0
4z90H-1x77A:
0.0
4z90I-1x77A:
0.0
4z90J-1x77A:
0.0		 4z90F-1x77A:
20.56
4z90G-1x77A:
20.56
4z90H-1x77A:
20.56
4z90I-1x77A:
20.56
4z90J-1x77A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1x77 CONSERVED
HYPOTHETICAL PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  26
LEU A  41
MET A  37
GLN A 174
 None
 1.43A 5uc3A-1x77A:
undetectable		 5uc3A-1x77A:
18.09