SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x7h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 1x7h PUTATIVE KETOACYL
REDUCTASE
(Streptomyces
coelicolor) 		5 / 9 GLY A 117
ASP A  63
GLY A  13
VAL A  74
ILE A  70
 None
NDP  A 301 (-3.7A)
NDP  A 301 (-3.3A)
None
None
 1.00A 1hxwA-1x7hA:
undetectable		 1hxwA-1x7hA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1x7h PUTATIVE KETOACYL
REDUCTASE
(Streptomyces
coelicolor) 		3 / 3 ILE A  70
LEU A  73
VAL A  77
 None
 0.15A 1mz9B-1x7hA:
undetectable		 1mz9B-1x7hA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1x7h PUTATIVE KETOACYL
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 LEU A  10
ALA A  14
ILE A  18
GLY A  92
LEU A  87
 None
None
NDP  A 301 (-3.9A)
NDP  A 301 (-3.2A)
None
 0.96A 2o4nA-1x7hA:
undetectable		 2o4nA-1x7hA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 1x7h PUTATIVE KETOACYL
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 117
ASP A  63
GLY A  13
VAL A  74
ILE A  70
 None
NDP  A 301 (-3.7A)
NDP  A 301 (-3.3A)
None
None
 0.88A 2o4sA-1x7hA:
undetectable		 2o4sA-1x7hA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1x7h PUTATIVE KETOACYL
REDUCTASE
(Streptomyces
coelicolor) 		4 / 8 LEU A  43
LEU A  73
ALA A  76
PHE A  34
 None
 0.88A 2vcvF-1x7hA:
undetectable		 2vcvF-1x7hA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1x7h PUTATIVE KETOACYL
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 ILE A 139
LEU A 171
VAL A  74
VAL A  77
PRO A  83
 None
 1.16A 2ygpA-1x7hA:
undetectable		 2ygpA-1x7hA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1x7h PUTATIVE KETOACYL
REDUCTASE
(Streptomyces
coelicolor) 		5 / 8 LEU A  31
VAL A  88
ILE A  22
VAL A 236
ARG A  25
 None
 1.41A 3kp6A-1x7hA:
undetectable
3kp6B-1x7hA:
undetectable		 3kp6A-1x7hA:
21.79
3kp6B-1x7hA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1x7h PUTATIVE KETOACYL
REDUCTASE
(Streptomyces
coelicolor) 		4 / 4 ASN A  90
SER A  16
ALA A  14
VAL A  35
 NDP  A 301 (-3.3A)
NDP  A 301 (-3.1A)
None
None
 1.26A 4x1kC-1x7hA:
6.9		 4x1kC-1x7hA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 1x7h PUTATIVE KETOACYL
REDUCTASE
(Streptomyces
coelicolor) 		4 / 4 VAL A 221
GLY A 224
ARG A 225
VAL A 227
 None
 1.36A 5d4nA-1x7hA:
0.0
5d4nB-1x7hA:
0.0		 5d4nA-1x7hA:
20.16
5d4nB-1x7hA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 1x7h PUTATIVE KETOACYL
REDUCTASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 117
ASP A  63
GLY A  13
VAL A  74
ILE A  70
 None
NDP  A 301 (-3.7A)
NDP  A 301 (-3.3A)
None
None
 0.84A 6dj1A-1x7hA:
undetectable		 6dj1A-1x7hA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1x7h PUTATIVE KETOACYL
REDUCTASE
(Streptomyces
coelicolor) 		4 / 8 GLY A 150
GLY A 188
SER A 144
ALA A 143
 None
NDP  A 301 (-4.9A)
NDP  A 301 (-3.6A)
None
 0.78A 6hu9H-1x7hA:
undetectable
6hu9e-1x7hA:
undetectable		 6hu9H-1x7hA:
15.23
6hu9e-1x7hA:
18.18