SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		3 / 3 ASP A 163
LYS A  34
ARG A  37
 None
 0.77A 1ra8A-1x7pA:
2.7		 1ra8A-1x7pA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		3 / 3 ASP A 163
LYS A 168
ARG A 171
 None
 0.56A 1ra8A-1x7pA:
2.7		 1ra8A-1x7pA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		7 / 12 GLY A 232
GLY A 237
ILE A 252
MET A 254
SER A 260
LEU A 261
ALA A 266
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
 0.73A 1v2xA-1x7pA:
19.2		 1v2xA-1x7pA:
25.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		10 / 11 THR A 210
GLU A 212
GLY A 232
GLY A 237
ILE A 252
MET A 254
SER A 260
LEU A 261
ALA A 263
ALA A 266
 SAM  A 301 (-3.6A)
SAM  A 301 (-4.8A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.8A)
SAM  A 301 (-3.4A)
 0.02A 1x7pA-1x7pA:
45.5
1x7pB-1x7pA:
33.3		 1x7pA-1x7pA:
100.00
1x7pB-1x7pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		6 / 10 THR A 210
ASP A 211
GLU A 212
ILE A 252
MET A 254
ALA A 266
 SAM  A 301 (-3.6A)
None
SAM  A 301 (-4.8A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
 0.82A 1x7pA-1x7pA:
45.5
1x7pB-1x7pA:
33.3		 1x7pA-1x7pA:
100.00
1x7pB-1x7pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		8 / 10 THR A 210
ASP A 211
GLY A 232
GLY A 237
ILE A 252
MET A 254
LEU A 261
ALA A 266
 SAM  A 301 (-3.6A)
None
SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
 0.39A 1x7pA-1x7pA:
45.5
1x7pB-1x7pA:
33.3		 1x7pA-1x7pA:
100.00
1x7pB-1x7pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 7 PHE A 126
LEU A 228
LEU A 207
ARG A 198
 None
 0.68A 2jn3A-1x7pA:
undetectable		 2jn3A-1x7pA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 10 LEU A 155
VAL A 129
GLY A 128
SER A 176
ALA A 147
 None
 0.98A 2v3kA-1x7pA:
9.6		 2v3kA-1x7pA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 12 PRO A 134
VAL A 157
LEU A 155
ILE A 144
SER A 169
 None
 1.15A 2xrlA-1x7pA:
0.4		 2xrlA-1x7pA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 11 THR A  36
VAL A 164
VAL A 185
ILE A 156
ALA A 114
 None
 1.22A 2zbzA-1x7pA:
undetectable		 2zbzA-1x7pA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 12 LEU A 177
VAL A 170
SER A 173
VAL A 110
LEU A  28
 None
 1.38A 2zlcA-1x7pA:
undetectable		 2zlcA-1x7pA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 7 SER A 146
LEU A 261
ALA A 269
THR A 268
 None
SAM  A 301 (-4.1A)
None
None
 1.04A 3cfqA-1x7pA:
undetectable
3cfqB-1x7pA:
undetectable		 3cfqA-1x7pA:
15.97
3cfqB-1x7pA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		3 / 3 THR A 268
SER A 146
PHE A 131
 None
 0.61A 3d4sA-1x7pA:
undetectable		 3d4sA-1x7pA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		6 / 11 THR A 210
GLY A 232
GLY A 237
ILE A 252
LEU A 261
ALA A 266
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
 0.49A 3dcmX-1x7pA:
14.3		 3dcmX-1x7pA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 4 LEU A 230
ALA A 158
VAL A 185
PRO A 188
 None
 1.24A 3gv1B-1x7pA:
undetectable		 3gv1B-1x7pA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 12 GLY A 232
ILE A 252
MET A 254
SER A 260
LEU A 261
 SAM  A 301 (-3.2A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
 0.83A 3gyqA-1x7pA:
20.3
3gyqB-1x7pA:
21.2		 3gyqA-1x7pA:
27.99
3gyqB-1x7pA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 11 GLY A 232
ILE A 252
MET A 254
SER A 260
LEU A 261
 SAM  A 301 (-3.2A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
 0.88A 3gyqB-1x7pA:
21.2		 3gyqB-1x7pA:
27.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		7 / 12 ASN A 139
GLY A 232
GLY A 237
ILE A 252
MET A 254
SER A 260
ASN A 262
 None
SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.7A)
None
 0.87A 3nk7A-1x7pA:
24.1		 3nk7A-1x7pA:
30.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		7 / 12 ASN A 139
GLY A 232
GLY A 237
ILE A 252
MET A 254
SER A 260
LEU A 261
 None
SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
 0.84A 3nk7B-1x7pA:
24.6		 3nk7B-1x7pA:
30.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		7 / 12 GLY A 232
GLU A 234
GLY A 237
ILE A 252
MET A 254
SER A 260
LEU A 261
 SAM  A 301 (-3.2A)
None
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
 1.14A 3nk7B-1x7pA:
24.6		 3nk7B-1x7pA:
30.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 7 LEU A 261
ALA A 269
THR A 268
SER A 146
 SAM  A 301 (-4.1A)
None
None
None
 0.99A 4ikjA-1x7pA:
undetectable
4ikjB-1x7pA:
undetectable		 4ikjA-1x7pA:
16.67
4ikjB-1x7pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 8 SER A 146
SER A 142
LEU A 261
ALA A 269
THR A 268
 None
None
SAM  A 301 (-4.1A)
None
None
 1.28A 4ikjA-1x7pA:
undetectable
4ikjB-1x7pA:
undetectable		 4ikjA-1x7pA:
16.67
4ikjB-1x7pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 8 LEU A 261
ALA A 269
THR A 268
SER A 146
SER A 142
 SAM  A 301 (-4.1A)
None
None
None
None
 1.23A 4ikkA-1x7pA:
undetectable
4ikkB-1x7pA:
undetectable		 4ikkA-1x7pA:
16.67
4ikkB-1x7pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 7 SER A 146
LEU A 261
ALA A 269
THR A 268
 None
SAM  A 301 (-4.1A)
None
None
 1.02A 4ikkA-1x7pA:
undetectable
4ikkB-1x7pA:
undetectable		 4ikkA-1x7pA:
16.67
4ikkB-1x7pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 8 SER A 176
SER A 179
HIS A  55
GLU A  54
 None
 1.22A 4ms4A-1x7pA:
3.4		 4ms4A-1x7pA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 8 ILE A 205
LEU A 229
ILE A 270
PHE A 126
 None
 0.86A 4r38D-1x7pA:
undetectable		 4r38D-1x7pA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 9 GLY A 232
ILE A 252
MET A 254
SER A 260
LEU A 261
 SAM  A 301 (-3.2A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
 0.87A 4x3mB-1x7pA:
27.9		 4x3mB-1x7pA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 12 ALA A 182
PHE A  41
TYR A 165
LEU A 155
VAL A 164
 None
 1.08A 5hw4A-1x7pA:
2.1		 5hw4A-1x7pA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 11 ALA A 182
PHE A  41
TYR A 165
LEU A 155
VAL A 164
 None
 1.10A 5hw4B-1x7pA:
2.4		 5hw4B-1x7pA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 12 ALA A 182
PHE A  41
TYR A 165
LEU A 155
VAL A 164
 None
 1.10A 5hw4C-1x7pA:
2.3		 5hw4C-1x7pA:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		7 / 12 THR A 210
GLY A 232
GLY A 237
ILE A 252
SER A 260
LEU A 261
ALA A 266
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
 0.65A 5l0zA-1x7pA:
29.3		 5l0zA-1x7pA:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		7 / 10 THR A 210
GLY A 232
GLY A 237
ILE A 252
SER A 260
LEU A 261
ALA A 266
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
 0.65A 5l0zB-1x7pA:
29.0		 5l0zB-1x7pA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 7 GLY A 232
GLY A 237
SER A 251
LEU A 261
ALA A 266
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
 0.58A 5o96C-1x7pA:
12.2		 5o96C-1x7pA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 11 GLY A 232
GLU A 234
GLY A 237
SER A 251
ALA A 266
 SAM  A 301 (-3.2A)
None
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.4A)
 0.92A 5o96G-1x7pA:
12.1		 5o96G-1x7pA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		5 / 11 ASP A 211
ILE A 231
GLY A 232
GLY A 237
LEU A 261
 None
SAM  A 301 (-4.2A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.1A)
 0.56A 5twjD-1x7pA:
8.2		 5twjD-1x7pA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 5 LEU A 150
ALA A 152
LEU A 127
LEU A 180
 None
 0.86A 5vkqA-1x7pA:
undetectable
5vkqD-1x7pA:
undetectable		 5vkqA-1x7pA:
10.91
5vkqD-1x7pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 5 LEU A 180
LEU A 150
ALA A 152
LEU A 127
 None
 0.86A 5vkqA-1x7pA:
undetectable
5vkqB-1x7pA:
undetectable		 5vkqA-1x7pA:
10.91
5vkqB-1x7pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 5 LEU A 180
LEU A 150
ALA A 152
LEU A 127
 None
 0.86A 5vkqB-1x7pA:
undetectable
5vkqC-1x7pA:
undetectable		 5vkqB-1x7pA:
10.91
5vkqC-1x7pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 5 LEU A 180
LEU A 150
ALA A 152
LEU A 127
 None
 0.89A 5vkqC-1x7pA:
undetectable
5vkqD-1x7pA:
undetectable		 5vkqC-1x7pA:
10.91
5vkqD-1x7pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 4 GLY A 232
ARG A 133
ASN A 233
LEU A 238
 SAM  A 301 (-3.2A)
None
None
None
 1.27A 6b58A-1x7pA:
2.5		 6b58A-1x7pA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 6 GLY A 232
ASN A 233
ASP A 132
ARG A 243
 SAM  A 301 (-3.2A)
None
None
None
 1.20A 6dwdA-1x7pA:
undetectable
6dwdC-1x7pA:
undetectable		 6dwdA-1x7pA:
19.89
6dwdC-1x7pA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 5 GLY A 232
ASN A 233
ASP A 132
ARG A 243
 SAM  A 301 (-3.2A)
None
None
None
 1.20A 6dwdB-1x7pA:
undetectable
6dwdD-1x7pA:
undetectable		 6dwdB-1x7pA:
19.89
6dwdD-1x7pA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1x7p RRNA
METHYLTRANSFERASE
(Streptomyces
viridochromogene
s) 		4 / 5 ARG A 243
GLY A 232
ASN A 233
ASP A 132
 None
SAM  A 301 (-3.2A)
None
None
 1.18A 6dwjB-1x7pA:
undetectable
6dwjD-1x7pA:
undetectable		 6dwjB-1x7pA:
19.89
6dwjD-1x7pA:
19.89