SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 166
THR A 260
ALA A 168
LEU A 189
 None
NAD  A 600 (-4.4A)
NAD  A 600 ( 4.3A)
None
 0.95A 1etb2-1x87A:
undetectable		 1etb2-1x87A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 135
GLY A 436
VAL A 359
SER A 131
HIS A 439
 None
 1.35A 1nbhA-1x87A:
6.7		 1nbhA-1x87A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 135
GLY A 436
VAL A 359
SER A 131
HIS A 439
 None
 1.35A 1nbhD-1x87A:
6.5		 1nbhD-1x87A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 166
THR A 165
LEU A 218
ILE A 191
GLY A 234
 None
 0.93A 1qknA-1x87A:
undetectable		 1qknA-1x87A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 GLN A 177
THR A 257
ARG A 197
ARG A 201
GLY A 234
 None
None
NAD  A 600 (-3.9A)
None
None
 1.49A 1v55A-1x87A:
0.0
1v55B-1x87A:
0.0
1v55T-1x87A:
0.0		 1v55A-1x87A:
20.44
1v55B-1x87A:
18.23
1v55T-1x87A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 ARG A 197
ARG A 201
GLY A 234
GLN A 177
THR A 257
 NAD  A 600 (-3.9A)
None
None
None
None
 1.47A 1v55G-1x87A:
0.0
1v55N-1x87A:
0.0
1v55O-1x87A:
0.0		 1v55G-1x87A:
9.12
1v55N-1x87A:
20.44
1v55O-1x87A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 472
ASN A 469
ALA A 497
LEU A  97
THR A 519
 None
 1.24A 1ya3B-1x87A:
undetectable		 1ya3B-1x87A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 269
ALA A 300
SER A 297
ASN A 238
 NAD  A 600 (-3.8A)
None
None
NAD  A 600 (-3.1A)
 1.10A 1yvpB-1x87A:
undetectable		 1yvpB-1x87A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 VAL A 483
ARG A 437
GLY A 476
ALA A 478
 None
 0.88A 2a1hA-1x87A:
undetectable
2a1hB-1x87A:
undetectable		 2a1hA-1x87A:
20.74
2a1hB-1x87A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 472
ASN A 469
ALA A 497
LEU A  97
THR A 519
 None
 1.26A 2aa5B-1x87A:
undetectable		 2aa5B-1x87A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 189
LEU A 235
LEU A 246
LEU A 256
 None
 1.01A 2ab2A-1x87A:
undetectable		 2ab2A-1x87A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_B_CHDB304_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 GLN A 177
THR A 257
ARG A 197
ARG A 201
GLY A 234
 None
None
NAD  A 600 (-3.9A)
None
None
 1.49A 2dysA-1x87A:
0.0
2dysB-1x87A:
0.0
2dysT-1x87A:
0.0		 2dysA-1x87A:
20.44
2dysB-1x87A:
18.23
2dysT-1x87A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 GLN A 177
THR A 257
ARG A 197
ARG A 201
GLY A 234
 None
None
NAD  A 600 (-3.9A)
None
None
 1.50A 2eijA-1x87A:
0.4
2eijB-1x87A:
0.0
2eijT-1x87A:
0.0		 2eijA-1x87A:
20.44
2eijB-1x87A:
18.23
2eijT-1x87A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 ARG A 197
ARG A 201
GLY A 234
GLN A 177
THR A 257
 NAD  A 600 (-3.9A)
None
None
None
None
 1.48A 2eikG-1x87A:
0.0
2eikN-1x87A:
0.0
2eikO-1x87A:
0.0		 2eikG-1x87A:
9.12
2eikN-1x87A:
20.44
2eikO-1x87A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 GLN A 177
THR A 257
ARG A 197
ARG A 201
GLY A 234
 None
None
NAD  A 600 (-3.9A)
None
None
 1.47A 2eilA-1x87A:
0.6
2eilB-1x87A:
0.0
2eilT-1x87A:
0.0		 2eilA-1x87A:
20.44
2eilB-1x87A:
18.23
2eilT-1x87A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 ARG A 197
ARG A 201
GLY A 234
GLN A 177
THR A 257
 NAD  A 600 (-3.9A)
None
None
None
None
 1.48A 2eilG-1x87A:
0.0
2eilN-1x87A:
0.0
2eilO-1x87A:
0.0		 2eilG-1x87A:
9.12
2eilN-1x87A:
20.44
2eilO-1x87A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 6 ARG A 404
GLU A 146
ASN A 184
ALA A 180
 None
 1.11A 2ejfB-1x87A:
1.8		 2ejfB-1x87A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 ARG A 404
GLU A 146
ASN A 184
ALA A 180
 None
 1.09A 2ejgA-1x87A:
undetectable		 2ejgA-1x87A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 6 PRO A 355
LEU A 348
ARG A 437
GLY A 524
 None
 1.25A 2hs2B-1x87A:
undetectable		 2hs2B-1x87A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 472
ASN A 469
ALA A 497
LEU A  97
THR A 519
 None
 1.28A 2oaxB-1x87A:
undetectable		 2oaxB-1x87A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 472
ASN A 469
ALA A 497
LEU A  97
THR A 519
 None
 1.26A 2oaxC-1x87A:
undetectable		 2oaxC-1x87A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 179
MET A 183
MET A 220
 None
 1.04A 2vavF-1x87A:
undetectable		 2vavF-1x87A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_L_CSCL1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 4 THR A 182
LEU A 179
MET A 183
MET A 220
 None
 1.50A 2vavL-1x87A:
0.0		 2vavL-1x87A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 ALA A 272
SER A 261
GLY A 268
SER A 297
ALA A 294
 None
NAD  A 600 (-3.7A)
None
None
None
 1.38A 2vh3A-1x87A:
0.0		 2vh3A-1x87A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 GLN A 177
THR A 257
ARG A 197
ARG A 201
GLY A 234
 None
None
NAD  A 600 (-3.9A)
None
None
 1.46A 2zxwA-1x87A:
0.0
2zxwB-1x87A:
0.0
2zxwT-1x87A:
0.0		 2zxwA-1x87A:
20.44
2zxwB-1x87A:
18.23
2zxwT-1x87A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 ARG A 197
ARG A 201
GLY A 234
GLN A 177
THR A 165
 NAD  A 600 (-3.9A)
None
None
None
None
 1.49A 2zxwG-1x87A:
0.0
2zxwN-1x87A:
1.1
2zxwO-1x87A:
0.0		 2zxwG-1x87A:
9.12
2zxwN-1x87A:
20.44
2zxwO-1x87A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 GLN A 177
THR A 257
ARG A 197
ARG A 201
GLY A 234
 None
None
NAD  A 600 (-3.9A)
None
None
 1.48A 3abkA-1x87A:
1.1
3abkB-1x87A:
0.0
3abkT-1x87A:
0.0		 3abkA-1x87A:
20.44
3abkB-1x87A:
18.23
3abkT-1x87A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 GLN A 177
THR A 165
ARG A 197
ARG A 201
GLY A 234
 None
None
NAD  A 600 (-3.9A)
None
None
 1.40A 3abmA-1x87A:
0.1
3abmB-1x87A:
0.0
3abmT-1x87A:
0.0		 3abmA-1x87A:
20.44
3abmB-1x87A:
18.23
3abmT-1x87A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 GLN A 177
THR A 165
ARG A 197
ARG A 201
GLY A 234
 None
None
NAD  A 600 (-3.9A)
None
None
 1.49A 3ag1A-1x87A:
0.1
3ag1B-1x87A:
0.0
3ag1T-1x87A:
0.0		 3ag1A-1x87A:
20.44
3ag1B-1x87A:
18.23
3ag1T-1x87A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 GLN A 177
THR A 165
ARG A 197
ARG A 201
GLY A 234
 None
None
NAD  A 600 (-3.9A)
None
None
 1.43A 3ag2A-1x87A:
0.0
3ag2B-1x87A:
0.0
3ag2T-1x87A:
0.0		 3ag2A-1x87A:
20.44
3ag2B-1x87A:
18.23
3ag2T-1x87A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 ALA A 221
ALA A 224
ILE A 233
THR A 209
 None
 0.59A 3dtuC-1x87A:
undetectable
3dtuD-1x87A:
undetectable		 3dtuC-1x87A:
22.91
3dtuD-1x87A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A 169
ILE A 191
GLU A 192
VAL A 193
ALA A 239
 NAD  A 600 ( 3.8A)
None
NAD  A 600 (-2.7A)
NAD  A 600 (-4.1A)
NAD  A 600 (-3.6A)
 0.57A 3dxyA-1x87A:
6.7		 3dxyA-1x87A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 169
GLY A 171
GLU A 192
ASP A 194
ALA A 239
 NAD  A 600 ( 3.8A)
NAD  A 600 (-3.3A)
NAD  A 600 (-2.7A)
None
NAD  A 600 (-3.6A)
 0.90A 3fuuA-1x87A:
5.9		 3fuuA-1x87A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A 169
GLY A 171
GLU A 192
ASP A 194
ALA A 239
 NAD  A 600 ( 3.8A)
NAD  A 600 (-3.3A)
NAD  A 600 (-2.7A)
None
NAD  A 600 (-3.6A)
 0.53A 3grvA-1x87A:
7.1		 3grvA-1x87A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 169
GLY A 171
GLU A 192
ASP A 194
ALA A 239
 NAD  A 600 ( 3.8A)
NAD  A 600 (-3.3A)
NAD  A 600 (-2.7A)
None
NAD  A 600 (-3.6A)
 0.50A 3gryA-1x87A:
7.1		 3gryA-1x87A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 ILE A 405
LEU A 408
PHE A 416
LEU A 361
GLY A 417
 None
 1.39A 3nxuB-1x87A:
undetectable		 3nxuB-1x87A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 5 PHE A 356
ARG A 413
GLU A 412
PHE A 379
 None
 1.11A 3r4xA-1x87A:
0.0		 3r4xA-1x87A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 472
ASN A 469
ALA A 497
LEU A  97
THR A 519
 None
 1.27A 3vhuA-1x87A:
undetectable		 3vhuA-1x87A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 166
THR A 260
ALA A 168
LEU A 189
 None
NAD  A 600 (-4.4A)
NAD  A 600 ( 4.3A)
None
 1.01A 4pwjA-1x87A:
undetectable		 4pwjA-1x87A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 THR A 519
ALA A 497
GLY A 476
GLY A 477
ALA A 478
 None
 1.05A 4qvmK-1x87A:
undetectable
4qvmL-1x87A:
undetectable		 4qvmK-1x87A:
18.02
4qvmL-1x87A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 THR A 519
ALA A 497
GLY A 476
GLY A 477
ALA A 478
 None
 1.06A 4qw1Y-1x87A:
undetectable
4qw1Z-1x87A:
undetectable		 4qw1Y-1x87A:
18.38
4qw1Z-1x87A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 THR A 519
ALA A 497
GLY A 476
GLY A 477
ALA A 478
 None
 1.04A 4qw3K-1x87A:
undetectable
4qw3L-1x87A:
undetectable		 4qw3K-1x87A:
18.20
4qw3L-1x87A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 THR A 519
ALA A 497
GLY A 476
GLY A 477
ALA A 478
 None
 1.03A 4qw3Y-1x87A:
undetectable
4qw3Z-1x87A:
undetectable		 4qw3Y-1x87A:
18.20
4qw3Z-1x87A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 ASN A  56
GLU A  58
GLU A  61
TYR A  60
 None
 1.11A 4r87I-1x87A:
undetectable		 4r87I-1x87A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 6 SER A 213
LEU A 214
ASP A 215
LEU A 235
 None
 1.04A 4wozA-1x87A:
undetectable
4wozB-1x87A:
undetectable		 4wozA-1x87A:
19.96
4wozB-1x87A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 ARG A 197
ARG A 201
GLY A 234
GLN A 177
THR A 257
 NAD  A 600 (-3.9A)
None
None
None
None
 1.46A 5b1bG-1x87A:
0.0
5b1bN-1x87A:
0.0
5b1bO-1x87A:
0.0		 5b1bG-1x87A:
9.12
5b1bN-1x87A:
20.44
5b1bO-1x87A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 ALA A 536
ASP A 520
ARG A 437
GLY A 354
 None
 0.89A 5bs8A-1x87A:
1.6
5bs8C-1x87A:
1.5
5bs8D-1x87A:
undetectable		 5bs8A-1x87A:
21.80
5bs8C-1x87A:
21.80
5bs8D-1x87A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 11 THR A 519
ALA A 497
GLY A 476
GLY A 477
ALA A 478
 None
 1.04A 5bxnY-1x87A:
undetectable
5bxnZ-1x87A:
undetectable		 5bxnY-1x87A:
18.20
5bxnZ-1x87A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 500
ALA A  24
VAL A 434
LEU A 513
LEU A  70
 None
 1.21A 5hv1A-1x87A:
undetectable		 5hv1A-1x87A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 4 GLN A 259
THR A 260
GLU A 192
LEU A 189
 NAD  A 600 (-3.5A)
NAD  A 600 (-4.4A)
NAD  A 600 (-2.7A)
None
 1.22A 5m66A-1x87A:
3.3		 5m66A-1x87A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 256
ALA A 239
LEU A 166
THR A 165
GLY A 174
 None
NAD  A 600 (-3.6A)
None
None
NAD  A 600 (-4.0A)
 0.94A 6b0cD-1x87A:
undetectable		 6b0cD-1x87A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 256
LEU A 243
LEU A 166
THR A 165
GLY A 174
 None
None
None
None
NAD  A 600 (-4.0A)
 0.93A 6b0cD-1x87A:
undetectable		 6b0cD-1x87A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		6 / 10 GLY A 169
GLY A 171
GLU A 192
VAL A 193
ASP A 194
THR A 260
 NAD  A 600 ( 3.8A)
NAD  A 600 (-3.3A)
NAD  A 600 (-2.7A)
NAD  A 600 (-4.1A)
None
NAD  A 600 (-4.4A)
 0.52A 6exiA-1x87A:
7.1		 6exiA-1x87A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		6 / 10 GLY A 169
GLY A 171
GLU A 192
VAL A 193
ASP A 194
THR A 260
 NAD  A 600 ( 3.8A)
NAD  A 600 (-3.3A)
NAD  A 600 (-2.7A)
NAD  A 600 (-4.1A)
None
NAD  A 600 (-4.4A)
 0.52A 6exiB-1x87A:
7.0		 6exiB-1x87A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		6 / 12 GLY A 169
GLY A 171
GLU A 192
VAL A 193
ASP A 194
THR A 260
 NAD  A 600 ( 3.8A)
NAD  A 600 (-3.3A)
NAD  A 600 (-2.7A)
NAD  A 600 (-4.1A)
None
NAD  A 600 (-4.4A)
 0.54A 6exiC-1x87A:
7.5
6exiD-1x87A:
7.5		 6exiC-1x87A:
10.32
6exiD-1x87A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1x87 UROCANASE PROTEIN
(Geobacillus
stearothermophil
us) 		6 / 12 GLY A 169
GLY A 171
GLU A 192
VAL A 193
ASP A 194
THR A 260
 NAD  A 600 ( 3.8A)
NAD  A 600 (-3.3A)
NAD  A 600 (-2.7A)
NAD  A 600 (-4.1A)
None
NAD  A 600 (-4.4A)
 0.49A 6exiC-1x87A:
7.5
6exiD-1x87A:
7.5		 6exiC-1x87A:
10.32
6exiD-1x87A:
10.32