SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x9d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		3 / 4 LYS A 416
ALA A 420
MET A 363
 None
 0.85A 1hk3A-1x9dA:
2.0		 1hk3A-1x9dA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 5 PHE A 518
GLY A 511
THR A 508
PHE A 509
 None
 1.37A 1icuC-1x9dA:
undetectable
1icuD-1x9dA:
undetectable		 1icuC-1x9dA:
17.36
1icuD-1x9dA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		5 / 12 TYR A 606
LEU A 403
GLU A 663
TYR A 468
GLU A 467
 None
None
SMD  A1003 (-2.9A)
None
CA  A1001 ( 4.2A)
 1.20A 1mmkA-1x9dA:
undetectable		 1mmkA-1x9dA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 4 LEU A 604
VAL A 601
ILE A 623
TRP A 619
 None
 1.49A 1s9qB-1x9dA:
0.0		 1s9qB-1x9dA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 8 TYR A 684
PHE A 605
ARG A 609
LEU A 345
 None
 1.17A 1x8vA-1x9dA:
undetectable		 1x8vA-1x9dA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		3 / 3 TRP A 299
LEU A 301
LYS A 666
 None
 1.37A 1yajK-1x9dA:
undetectable		 1yajK-1x9dA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		3 / 3 PHE A 307
SER A 341
LEU A 339
 None
 0.80A 2w1bA-1x9dA:
0.0		 2w1bA-1x9dA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 6 GLU A 330
ASN A 327
TRP A 284
SER A 658
 SMD  A1003 ( 4.3A)
None
None
None
 1.46A 3i9jB-1x9dA:
undetectable		 3i9jB-1x9dA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 6 LEU A 595
GLU A 570
ARG A 597
HIS A 524
 None
None
SMD  A1003 (-3.8A)
None
 1.37A 3ltwA-1x9dA:
undetectable		 3ltwA-1x9dA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 5 LEU A 681
PHE A 686
PHE A 605
ARG A 609
 None
 0.83A 3smtA-1x9dA:
undetectable		 3smtA-1x9dA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		3 / 4 ARG A 495
GLY A 493
GLU A 492
 None
 0.56A 4z2dB-1x9dA:
undetectable
4z2dC-1x9dA:
undetectable		 4z2dB-1x9dA:
22.46
4z2dC-1x9dA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		5 / 10 LEU A 408
ALA A 355
SER A 346
LEU A 345
ALA A 342
 None
 1.16A 4zbrA-1x9dA:
2.6		 4zbrA-1x9dA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		5 / 12 LEU A 336
LEU A 339
ALA A 342
SER A 349
LEU A 350
 None
 1.11A 5mwyA-1x9dA:
undetectable		 5mwyA-1x9dA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 7 GLN A 402
ASP A 486
ALA A 490
LEU A 438
 None
 1.04A 5nwvA-1x9dA:
0.0		 5nwvA-1x9dA:
6.48