SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x9e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DVX_B_DIFB125_1 (TRANSTHYRETIN)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	4 / 7	LEU A 289 ALA A 292 SER A 270 SER A 266	None	0.99A	1dvxA-1x9eA: undetectable	1dvxA-1x9eA: 16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM6_U_9CRU502_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	6 / 12	ALA A 155 ALA A 43 ALA A 141 ILE A 286 HIS A 332 LEU A 336	None	1.35A	1fm6U-1x9eA: undetectable	1fm6U-1x9eA: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GSF_C_EAAC223_1 (GLUTATHIONE TRANSFERASE A1-1)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	4 / 8	TYR A 205 PHE A 209 GLY A 240 PHE A 304	None	0.88A	1gsfC-1x9eA: undetectable	1gsfC-1x9eA: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NT2_A_SAMA301_1 (FIBRILLARIN-LIKE PRE-RRNA PROCESSING PROTEIN)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	3 / 3	THR A 278 GLU A 109 ASP A 181	None	0.78A	1nt2A-1x9eA: undetectable	1nt2A-1x9eA: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RBP_A_RTLA183_0 (PLASMA RETINOL-BINDING PROTEIN PRECURSOR)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	LEU A 303 ALA A 58 ALA A 55 ALA A 159 LEU A 118	None	1.28A	1rbpA-1x9eA: undetectable	1rbpA-1x9eA: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XL6_B_SPMB3001_1 (INWARD RECTIFIER POTASSIUM CHANNEL)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	4 / 5	ALA A 349 ALA A 345 TYR A 347 GLN A 153	None	1.10A	1xl6A-1x9eA: undetectable 1xl6B-1x9eA: undetectable	1xl6A-1x9eA: 23.21 1xl6B-1x9eA: 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F16_H_BO2H1400_1 (PROTEASOME COMPONENT PUP1 PROTEASOME COMPONENT PUP3)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 11	ALA A 56 ALA A 114 GLY A 77 THR A 78 ALA A 138	None	1.12A	2f16H-1x9eA: undetectable 2f16I-1x9eA: undetectable	2f16H-1x9eA: 22.16 2f16I-1x9eA: 22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F16_K_BO2K1402_1 (PROTEASOME COMPONENT PRE2 PROTEASOME COMPONENT C5)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 10	THR A 278 ALA A 157 ALA A 159 ALA A 58 GLY A 77	None	1.02A	2f16K-1x9eA: undetectable 2f16L-1x9eA: undetectable	2f16K-1x9eA: 21.52 2f16L-1x9eA: 18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F16_V_BO2V1401_1 (PROTEASOME COMPONENT PUP1 PROTEASOME COMPONENT PUP3)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 11	ALA A 56 ALA A 114 GLY A 77 THR A 78 ALA A 138	None	1.12A	2f16V-1x9eA: undetectable 2f16W-1x9eA: undetectable	2f16V-1x9eA: 22.16 2f16W-1x9eA: 22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F16_Y_BO2Y1403_1 (PROTEASOME COMPONENT PRE2 PROTEASOME COMPONENT C5)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 10	THR A 278 ALA A 157 ALA A 159 ALA A 58 GLY A 77	None	1.02A	2f16Y-1x9eA: undetectable 2f16Z-1x9eA: undetectable	2f16Y-1x9eA: 21.52 2f16Z-1x9eA: 18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_A_TFPA202_1 (PROTEIN S100-A4)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	LEU A 285 SER A 266 ILE A 301 PHE A 224 LEU A 303	None	1.16A	3ko0A-1x9eA: undetectable 3ko0B-1x9eA: 0.0 3ko0C-1x9eA: undetectable 3ko0D-1x9eA: undetectable	3ko0A-1x9eA: 14.44 3ko0B-1x9eA: 14.44 3ko0C-1x9eA: 14.44 3ko0D-1x9eA: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_J_TFPJ202_1 (PROTEIN S100-A4)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 11	LEU A 303 LEU A 285 SER A 266 ILE A 301 PHE A 224	None	1.12A	3ko0A-1x9eA: undetectable 3ko0B-1x9eA: 0.0 3ko0I-1x9eA: 0.0 3ko0J-1x9eA: 0.0	3ko0A-1x9eA: 14.44 3ko0B-1x9eA: 14.44 3ko0I-1x9eA: 14.44 3ko0J-1x9eA: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_K_TFPK202_1 (PROTEIN S100-A4)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	LEU A 285 SER A 266 ILE A 301 PHE A 224 LEU A 303	None	1.12A	3ko0K-1x9eA: 0.0 3ko0L-1x9eA: undetectable 3ko0S-1x9eA: 0.0 3ko0T-1x9eA: undetectable	3ko0K-1x9eA: 14.44 3ko0L-1x9eA: 14.44 3ko0S-1x9eA: 14.44 3ko0T-1x9eA: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_L_TFPL202_1 (PROTEIN S100-A4)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	LEU A 303 LEU A 285 SER A 266 ILE A 301 PHE A 224	None	1.12A	3ko0K-1x9eA: 0.0 3ko0L-1x9eA: undetectable 3ko0M-1x9eA: 0.0 3ko0N-1x9eA: undetectable	3ko0K-1x9eA: 14.44 3ko0L-1x9eA: 14.44 3ko0M-1x9eA: 14.44 3ko0N-1x9eA: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_M_TFPM202_1 (PROTEIN S100-A4)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	LEU A 285 SER A 266 ILE A 301 PHE A 224 LEU A 303	None	1.14A	3ko0M-1x9eA: 0.0 3ko0N-1x9eA: undetectable 3ko0O-1x9eA: undetectable 3ko0P-1x9eA: undetectable	3ko0M-1x9eA: 14.44 3ko0N-1x9eA: 14.44 3ko0O-1x9eA: 14.44 3ko0P-1x9eA: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_P_TFPP202_1 (PROTEIN S100-A4)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	LEU A 303 LEU A 285 SER A 266 ILE A 301 PHE A 224	None	1.14A	3ko0M-1x9eA: 0.0 3ko0N-1x9eA: undetectable 3ko0O-1x9eA: undetectable 3ko0P-1x9eA: undetectable	3ko0M-1x9eA: 14.44 3ko0N-1x9eA: 14.44 3ko0O-1x9eA: 14.44 3ko0P-1x9eA: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MG0_V_BO2V1401_1 (PROTEASOME COMPONENT PUP1 PROTEASOME COMPONENT PUP3)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 11	ALA A 56 ALA A 114 GLY A 77 THR A 78 ALA A 138	None	1.10A	3mg0V-1x9eA: undetectable 3mg0W-1x9eA: undetectable	3mg0V-1x9eA: 22.16 3mg0W-1x9eA: 22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NRR_A_D16A530_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	ALA A 58 SER A 9 ILE A 286 LEU A 276 GLY A 279	None	1.18A	3nrrA-1x9eA: undetectable	3nrrA-1x9eA: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NRR_B_D16B530_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	ALA A 58 SER A 9 ILE A 286 LEU A 276 GLY A 279	None	1.16A	3nrrB-1x9eA: undetectable	3nrrB-1x9eA: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AC9_C_DXCC1476_0 (MJ0495-LIKE PROTEIN)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	4 / 5	ALA A 56 HIS A 93 MET A 96 ARG A 94	None	1.26A	4ac9B-1x9eA: undetectable 4ac9C-1x9eA: undetectable	4ac9B-1x9eA: 20.12 4ac9C-1x9eA: 20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACA_C_DXCC1476_0 (TRANSLATION ELONGATION FACTOR SELB)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	4 / 5	ALA A 56 HIS A 93 MET A 96 ARG A 94	None	1.24A	4acaB-1x9eA: undetectable 4acaC-1x9eA: undetectable	4acaB-1x9eA: 20.12 4acaC-1x9eA: 20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DF2_A_4CHA506_0 (NADPH DEHYDROGENASE)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	4 / 6	THR A 152 TYR A 143 HIS A 233 TYR A 277	None None SO4 A 385 (-4.4A) SO4 A 385 (-4.7A)	1.49A	4df2A-1x9eA: undetectable	4df2A-1x9eA: 24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MF6_A_BEZA303_0 (GLUTATHIONE S-TRANSFERASE DOMAIN)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	4 / 5	THR A 152 PHE A 185 ASN A 275 TYR A 277	None SO4 A 385 ( 3.9A) SO4 A 385 (-3.2A) SO4 A 385 (-4.7A)	1.48A	4mf6A-1x9eA: 0.0	4mf6A-1x9eA: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OAD_A_CLMA205_0 (GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	PHE A 315 ALA A 243 GLY A 240 LEU A 244 TYR A 263	None	1.49A	4oadA-1x9eA: undetectable	4oadA-1x9eA: 18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW0_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 11	ALA A 114 GLY A 77 THR A 78 ALA A 138 THR A 278	None	1.28A	4qw0H-1x9eA: undetectable 4qw0I-1x9eA: undetectable	4qw0H-1x9eA: 21.59 4qw0I-1x9eA: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW0_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 11	ALA A 114 GLY A 77 THR A 78 ALA A 138 THR A 278	None	1.27A	4qw0V-1x9eA: undetectable 4qw0W-1x9eA: undetectable	4qw0V-1x9eA: 21.59 4qw0W-1x9eA: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW1_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	ALA A 114 GLY A 77 THR A 78 ALA A 138 THR A 278	None	1.26A	4qw1H-1x9eA: undetectable 4qw1I-1x9eA: undetectable	4qw1H-1x9eA: 21.59 4qw1I-1x9eA: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW1_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	ALA A 114 GLY A 77 THR A 78 ALA A 138 THR A 278	None	1.26A	4qw1V-1x9eA: undetectable 4qw1W-1x9eA: undetectable	4qw1V-1x9eA: 21.59 4qw1W-1x9eA: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1I_B_LOCB502_2 (TUBULIN BETA CHAIN)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	ALA A 88 LEU A 92 MET A 96 ALA A 59 ALA A 157	None	1.26A	4x1iB-1x9eA: undetectable	4x1iB-1x9eA: 19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z91_J_4LEJ401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	6 / 9	LEU A 285 ALA A 231 LEU A 288 ALA A 229 LEU A 319 LEU A 169	None	1.15A	4z91F-1x9eA: undetectable 4z91G-1x9eA: undetectable 4z91H-1x9eA: undetectable 4z91I-1x9eA: undetectable 4z91J-1x9eA: undetectable	4z91F-1x9eA: 22.57 4z91G-1x9eA: 22.57 4z91H-1x9eA: 22.57 4z91I-1x9eA: 22.57 4z91J-1x9eA: 22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSA_B_X2NB590_1 (CYP51 VARIANT1)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	TYR A 227 LEU A 281 TYR A 112 ILE A 75 PHE A 314	None	1.18A	5fsaB-1x9eA: undetectable	5fsaB-1x9eA: 18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5Z_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 9	THR A 278 ALA A 157 ALA A 159 ALA A 58 GLY A 77	None	0.95A	5l5zK-1x9eA: undetectable 5l5zL-1x9eA: undetectable	5l5zK-1x9eA: 21.83 5l5zL-1x9eA: 18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5Z_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 9	THR A 278 ALA A 157 ALA A 159 ALA A 58 GLY A 77	None	0.95A	5l5zY-1x9eA: undetectable 5l5zZ-1x9eA: undetectable	5l5zY-1x9eA: 21.83 5l5zZ-1x9eA: 18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L66_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	ALA A 114 GLY A 77 THR A 78 ALA A 138 THR A 278	None	1.28A	5l66H-1x9eA: undetectable 5l66I-1x9eA: undetectable	5l66H-1x9eA: 21.59 5l66I-1x9eA: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L66_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	ALA A 114 GLY A 77 THR A 78 ALA A 138 THR A 278	None	1.28A	5l66V-1x9eA: undetectable 5l66W-1x9eA: undetectable	5l66V-1x9eA: 21.59 5l66W-1x9eA: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_H_6V8H305_0 (PROTEASOME SUBUNIT BETA TYPE-3 PROTEASOME SUBUNIT BETA TYPE-7)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 11	THR A 53 ALA A 155 GLY A 156 ALA A 138 LEU A 134	None	0.75A	5lf7H-1x9eA: undetectable 5lf7I-1x9eA: undetectable	5lf7H-1x9eA: 22.25 5lf7I-1x9eA: 19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFJ_A_SAMA501_0 (MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	ALA A 159 GLY A 117 THR A 278 LEU A 161 LEU A 63	None	1.01A	5nfjA-1x9eA: undetectable	5nfjA-1x9eA: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A5Z_L_9CRL501_0 (RETINOIC ACID RECEPTOR RXR-ALPHA)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	6 / 12	ALA A 155 ALA A 43 ALA A 141 ILE A 286 HIS A 332 LEU A 336	None	1.43A	6a5zL-1x9eA: undetectable	6a5zL-1x9eA: 14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B58_A_ACTA609_0 (FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	3 / 3	HIS A 128 HIS A 124 ARG A 103	None	1.10A	6b58A-1x9eA: undetectable	6b58A-1x9eA: 22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EMU_B_SAMB301_0 (TRNA (GUANINE(9)-/ADENINE (9)-N1)-METHYLTRANSF ERASE)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 12	ILE A 107 GLY A 113 VAL A 162 VAL A 133 ILE A 75	None	1.07A	6emuB-1x9eA: undetectable	6emuB-1x9eA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_V_BO2V301_0 (PROTEASOME SUBUNIT BETA TYPE-2)	1x9e	HMG-COA SYNTHASE (Enterococcus faecalis)	5 / 11	ALA A 56 GLY A 77 THR A 78 ALA A 138 THR A 278	None	1.09A	6hwdV-1x9eA: undetectable	6hwdV-1x9eA: 15.13

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DVX_B_DIFB125_1","TRANSTHYRETIN;TRANSTHYRETIN","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",4,"LEU A 289;ALA A 292;SER A 270;SER A 266","None","0.99A","1dvxA-1x9eA:undetectable","1dvxA-1x9eA:16.41"],["1FM6_U_9CRU502_1","RETINOIC ACID RECEPTOR RXR-ALPHA","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",6,"ALA A 155;ALA A  43;ALA A 141;ILE A 286;HIS A 332;LEU A 336","None","1.35A","1fm6U-1x9eA:undetectable","1fm6U-1x9eA:21.41"],["1GSF_C_EAAC223_1","GLUTATHIONE TRANSFERASE A1-1","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",4,"TYR A 205;PHE A 209;GLY A 240;PHE A 304","None","0.88A","1gsfC-1x9eA:undetectable","1gsfC-1x9eA:20.88"],["1NT2_A_SAMA301_1","FIBRILLARIN-LIKE PRE-RRNA PROCESSING PROTEIN","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",3,"THR A 278;GLU A 109;ASP A 181","None","0.78A","1nt2A-1x9eA:undetectable","1nt2A-1x9eA:21.83"],["1RBP_A_RTLA183_0","PLASMA RETINOL-BINDING PROTEIN PRECURSOR","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"LEU A 303;ALA A  58;ALA A  55;ALA A 159;LEU A 118","None","1.28A","1rbpA-1x9eA:undetectable","1rbpA-1x9eA:19.22"],["1XL6_B_SPMB3001_1","INWARD RECTIFIER POTASSIUM CHANNEL;INWARD RECTIFIER POTASSIUM CHANNEL","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",4,"ALA A 349;ALA A 345;TYR A 347;GLN A 153","None","1.10A","1xl6A-1x9eA:undetectable;1xl6B-1x9eA:undetectable","1xl6A-1x9eA:23.21;1xl6B-1x9eA:23.21"],["2F16_H_BO2H1400_1","PROTEASOME COMPONENT PUP1;PROTEASOME COMPONENT PUP3","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A  56;ALA A 114;GLY A  77;THR A  78;ALA A 138","None","1.12A","2f16H-1x9eA:undetectable;2f16I-1x9eA:undetectable","2f16H-1x9eA:22.16;2f16I-1x9eA:22.04"],["2F16_K_BO2K1402_1","PROTEASOME COMPONENT PRE2;PROTEASOME COMPONENT C5","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"THR A 278;ALA A 157;ALA A 159;ALA A  58;GLY A  77","None","1.02A","2f16K-1x9eA:undetectable;2f16L-1x9eA:undetectable","2f16K-1x9eA:21.52;2f16L-1x9eA:18.58"],["2F16_V_BO2V1401_1","PROTEASOME COMPONENT PUP1;PROTEASOME COMPONENT PUP3","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A  56;ALA A 114;GLY A  77;THR A  78;ALA A 138","None","1.12A","2f16V-1x9eA:undetectable;2f16W-1x9eA:undetectable","2f16V-1x9eA:22.16;2f16W-1x9eA:22.04"],["2F16_Y_BO2Y1403_1","PROTEASOME COMPONENT PRE2;PROTEASOME COMPONENT C5","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"THR A 278;ALA A 157;ALA A 159;ALA A  58;GLY A  77","None","1.02A","2f16Y-1x9eA:undetectable;2f16Z-1x9eA:undetectable","2f16Y-1x9eA:21.52;2f16Z-1x9eA:18.58"],["3KO0_A_TFPA202_1","PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"LEU A 285;SER A 266;ILE A 301;PHE A 224;LEU A 303","None","1.16A","3ko0A-1x9eA:undetectable;3ko0B-1x9eA:0.0;3ko0C-1x9eA:undetectable;3ko0D-1x9eA:undetectable","3ko0A-1x9eA:14.44;3ko0B-1x9eA:14.44;3ko0C-1x9eA:14.44;3ko0D-1x9eA:14.44"],["3KO0_J_TFPJ202_1","PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"LEU A 303;LEU A 285;SER A 266;ILE A 301;PHE A 224","None","1.12A","3ko0A-1x9eA:undetectable;3ko0B-1x9eA:0.0;3ko0I-1x9eA:0.0;3ko0J-1x9eA:0.0","3ko0A-1x9eA:14.44;3ko0B-1x9eA:14.44;3ko0I-1x9eA:14.44;3ko0J-1x9eA:14.44"],["3KO0_K_TFPK202_1","PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"LEU A 285;SER A 266;ILE A 301;PHE A 224;LEU A 303","None","1.12A","3ko0K-1x9eA:0.0;3ko0L-1x9eA:undetectable;3ko0S-1x9eA:0.0;3ko0T-1x9eA:undetectable","3ko0K-1x9eA:14.44;3ko0L-1x9eA:14.44;3ko0S-1x9eA:14.44;3ko0T-1x9eA:14.44"],["3KO0_L_TFPL202_1","PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"LEU A 303;LEU A 285;SER A 266;ILE A 301;PHE A 224","None","1.12A","3ko0K-1x9eA:0.0;3ko0L-1x9eA:undetectable;3ko0M-1x9eA:0.0;3ko0N-1x9eA:undetectable","3ko0K-1x9eA:14.44;3ko0L-1x9eA:14.44;3ko0M-1x9eA:14.44;3ko0N-1x9eA:14.44"],["3KO0_M_TFPM202_1","PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"LEU A 285;SER A 266;ILE A 301;PHE A 224;LEU A 303","None","1.14A","3ko0M-1x9eA:0.0;3ko0N-1x9eA:undetectable;3ko0O-1x9eA:undetectable;3ko0P-1x9eA:undetectable","3ko0M-1x9eA:14.44;3ko0N-1x9eA:14.44;3ko0O-1x9eA:14.44;3ko0P-1x9eA:14.44"],["3KO0_P_TFPP202_1","PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"LEU A 303;LEU A 285;SER A 266;ILE A 301;PHE A 224","None","1.14A","3ko0M-1x9eA:0.0;3ko0N-1x9eA:undetectable;3ko0O-1x9eA:undetectable;3ko0P-1x9eA:undetectable","3ko0M-1x9eA:14.44;3ko0N-1x9eA:14.44;3ko0O-1x9eA:14.44;3ko0P-1x9eA:14.44"],["3MG0_V_BO2V1401_1","PROTEASOME COMPONENT PUP1;PROTEASOME COMPONENT PUP3","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A  56;ALA A 114;GLY A  77;THR A  78;ALA A 138","None","1.10A","3mg0V-1x9eA:undetectable;3mg0W-1x9eA:undetectable","3mg0V-1x9eA:22.16;3mg0W-1x9eA:22.04"],["3NRR_A_D16A530_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A  58;SER A   9;ILE A 286;LEU A 276;GLY A 279","None","1.18A","3nrrA-1x9eA:undetectable","3nrrA-1x9eA:22.20"],["3NRR_B_D16B530_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A  58;SER A   9;ILE A 286;LEU A 276;GLY A 279","None","1.16A","3nrrB-1x9eA:undetectable","3nrrB-1x9eA:22.20"],["4AC9_C_DXCC1476_0","MJ0495-LIKE PROTEIN","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",4,"ALA A  56;HIS A  93;MET A  96;ARG A  94","None","1.26A","4ac9B-1x9eA:undetectable;4ac9C-1x9eA:undetectable","4ac9B-1x9eA:20.12;4ac9C-1x9eA:20.12"],["4ACA_C_DXCC1476_0","TRANSLATION ELONGATION FACTOR SELB","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",4,"ALA A  56;HIS A  93;MET A  96;ARG A  94","None","1.24A","4acaB-1x9eA:undetectable;4acaC-1x9eA:undetectable","4acaB-1x9eA:20.12;4acaC-1x9eA:20.12"],["4DF2_A_4CHA506_0","NADPH DEHYDROGENASE","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",4,"THR A 152;TYR A 143;HIS A 233;TYR A 277","None;None;SO4 A 385 (-4.4A);SO4 A 385 (-4.7A)","1.49A","4df2A-1x9eA:undetectable","4df2A-1x9eA:24.00"],["4MF6_A_BEZA303_0","GLUTATHIONE S-TRANSFERASE DOMAIN","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",4,"THR A 152;PHE A 185;ASN A 275;TYR A 277","None;SO4 A 385 ( 3.9A);SO4 A 385 (-3.2A);SO4 A 385 (-4.7A)","1.48A","4mf6A-1x9eA:0.0","4mf6A-1x9eA:21.24"],["4OAD_A_CLMA205_0","GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"PHE A 315;ALA A 243;GLY A 240;LEU A 244;TYR A 263","None","1.49A","4oadA-1x9eA:undetectable","4oadA-1x9eA:18.96"],["4QW0_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A 114;GLY A  77;THR A  78;ALA A 138;THR A 278","None","1.28A","4qw0H-1x9eA:undetectable;4qw0I-1x9eA:undetectable","4qw0H-1x9eA:21.59;4qw0I-1x9eA:21.83"],["4QW0_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A 114;GLY A  77;THR A  78;ALA A 138;THR A 278","None","1.27A","4qw0V-1x9eA:undetectable;4qw0W-1x9eA:undetectable","4qw0V-1x9eA:21.59;4qw0W-1x9eA:21.83"],["4QW1_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A 114;GLY A  77;THR A  78;ALA A 138;THR A 278","None","1.26A","4qw1H-1x9eA:undetectable;4qw1I-1x9eA:undetectable","4qw1H-1x9eA:21.59;4qw1I-1x9eA:21.83"],["4QW1_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A 114;GLY A  77;THR A  78;ALA A 138;THR A 278","None","1.26A","4qw1V-1x9eA:undetectable;4qw1W-1x9eA:undetectable","4qw1V-1x9eA:21.59;4qw1W-1x9eA:21.83"],["4X1I_B_LOCB502_2","TUBULIN BETA CHAIN","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A  88;LEU A  92;MET A  96;ALA A  59;ALA A 157","None","1.26A","4x1iB-1x9eA:undetectable","4x1iB-1x9eA:19.75"],["4Z91_J_4LEJ401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",6,"LEU A 285;ALA A 231;LEU A 288;ALA A 229;LEU A 319;LEU A 169","None","1.15A","4z91F-1x9eA:undetectable;4z91G-1x9eA:undetectable;4z91H-1x9eA:undetectable;4z91I-1x9eA:undetectable;4z91J-1x9eA:undetectable","4z91F-1x9eA:22.57;4z91G-1x9eA:22.57;4z91H-1x9eA:22.57;4z91I-1x9eA:22.57;4z91J-1x9eA:22.57"],["5FSA_B_X2NB590_1","CYP51 VARIANT1","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"TYR A 227;LEU A 281;TYR A 112;ILE A  75;PHE A 314","None","1.18A","5fsaB-1x9eA:undetectable","5fsaB-1x9eA:18.96"],["5L5Z_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"THR A 278;ALA A 157;ALA A 159;ALA A  58;GLY A  77","None","0.95A","5l5zK-1x9eA:undetectable;5l5zL-1x9eA:undetectable","5l5zK-1x9eA:21.83;5l5zL-1x9eA:18.72"],["5L5Z_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"THR A 278;ALA A 157;ALA A 159;ALA A  58;GLY A  77","None","0.95A","5l5zY-1x9eA:undetectable;5l5zZ-1x9eA:undetectable","5l5zY-1x9eA:21.83;5l5zZ-1x9eA:18.72"],["5L66_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A 114;GLY A  77;THR A  78;ALA A 138;THR A 278","None","1.28A","5l66H-1x9eA:undetectable;5l66I-1x9eA:undetectable","5l66H-1x9eA:21.59;5l66I-1x9eA:21.83"],["5L66_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A 114;GLY A  77;THR A  78;ALA A 138;THR A 278","None","1.28A","5l66V-1x9eA:undetectable;5l66W-1x9eA:undetectable","5l66V-1x9eA:21.59;5l66W-1x9eA:21.83"],["5LF7_H_6V8H305_0","PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"THR A  53;ALA A 155;GLY A 156;ALA A 138;LEU A 134","None","0.75A","5lf7H-1x9eA:undetectable;5lf7I-1x9eA:undetectable","5lf7H-1x9eA:22.25;5lf7I-1x9eA:19.19"],["5NFJ_A_SAMA501_0","MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A 159;GLY A 117;THR A 278;LEU A 161;LEU A  63","None","1.01A","5nfjA-1x9eA:undetectable","5nfjA-1x9eA:20.68"],["6A5Z_L_9CRL501_0","RETINOIC ACID RECEPTOR RXR-ALPHA","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",6,"ALA A 155;ALA A  43;ALA A 141;ILE A 286;HIS A 332;LEU A 336","None","1.43A","6a5zL-1x9eA:undetectable","6a5zL-1x9eA:14.20"],["6B58_A_ACTA609_0","FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",3,"HIS A 128;HIS A 124;ARG A 103","None","1.10A","6b58A-1x9eA:undetectable","6b58A-1x9eA:22.32"],["6EMU_B_SAMB301_0","TRNA (GUANINE(9)-\/ADENINE(9)-N1)-METHYLTRANSFERASE","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ILE A 107;GLY A 113;VAL A 162;VAL A 133;ILE A  75","None","1.07A","6emuB-1x9eA:undetectable","6emuB-1x9eA:19.89"],["6HWD_V_BO2V301_0","PROTEASOME SUBUNIT BETA TYPE-2","1x9e","HMG-COA SYNTHASE","Enterococcus faecalis",5,"ALA A  56;GLY A  77;THR A  78;ALA A 138;THR A 278","None","1.09A","6hwdV-1x9eA:undetectable","6hwdV-1x9eA:15.13"]]