SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		4 / 8 GLY A 109
ALA A  54
THR A  14
ILE A   7
 None
 0.71A 1gtnA-1x9jA:
undetectable
1gtnB-1x9jA:
undetectable		 1gtnA-1x9jA:
13.28
1gtnB-1x9jA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		4 / 8 GLY A 109
ALA A  54
THR A  14
ILE A   7
 None
 0.79A 1gtnP-1x9jA:
undetectable
1gtnQ-1x9jA:
undetectable		 1gtnP-1x9jA:
13.28
1gtnQ-1x9jA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 11 ALA A 282
ALA A 278
VAL A 259
MET A 277
LEU A 247
 None
 1.32A 1hbpA-1x9jA:
undetectable		 1hbpA-1x9jA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		4 / 8 MET A  92
ARG A  74
VAL A  85
GLY A  84
 None
GOL  A 395 ( 4.6A)
None
None
 0.98A 1hrkA-1x9jA:
2.8		 1hrkA-1x9jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		4 / 8 MET A  92
ARG A  74
VAL A  85
GLY A  84
 None
GOL  A 395 ( 4.6A)
None
None
 0.97A 1hrkB-1x9jA:
2.8		 1hrkB-1x9jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		4 / 8 GLY A 109
ALA A  54
THR A  14
ILE A   7
 None
 0.76A 1utdB-1x9jA:
undetectable
1utdC-1x9jA:
undetectable		 1utdB-1x9jA:
13.28
1utdC-1x9jA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		4 / 8 GLY A 109
ALA A  54
THR A  14
ILE A   7
 None
 0.77A 1utdF-1x9jA:
undetectable
1utdG-1x9jA:
undetectable		 1utdF-1x9jA:
13.28
1utdG-1x9jA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		4 / 8 GLY A 109
ALA A  54
THR A  14
ILE A   7
 None
 0.74A 1utdJ-1x9jA:
undetectable
1utdK-1x9jA:
undetectable		 1utdJ-1x9jA:
13.28
1utdK-1x9jA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		4 / 5 SER A 341
GLU A 334
SER A 106
ASP A 128
 None
 1.12A 1vidA-1x9jA:
undetectable		 1vidA-1x9jA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 9 LEU A  77
HIS A 114
ALA A 110
GLU A  51
LEU A  47
 None
 1.38A 2azqA-1x9jA:
undetectable		 2azqA-1x9jA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 9 LEU A 156
THR A 302
VAL A 161
THR A 160
ALA A 337
 None
 1.12A 2m9qA-1x9jA:
undetectable		 2m9qA-1x9jA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 11 LEU A  65
ILE A   7
PHE A  71
ALA A 113
ARG A 347
 None
 1.41A 2v0mA-1x9jA:
undetectable		 2v0mA-1x9jA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 12 VAL A 179
ALA A 190
ALA A 162
VAL A 165
MET A 288
 None
 1.11A 3czhA-1x9jA:
undetectable		 3czhA-1x9jA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		3 / 3 MET A 176
MET A 288
PHE A 298
 None
 1.02A 3gn8A-1x9jA:
undetectable		 3gn8A-1x9jA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 9 VAL A 320
PHE A 322
ILE A 285
ALA A 290
VAL A 296
 None
 1.28A 3me6D-1x9jA:
undetectable		 3me6D-1x9jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		3 / 3 GLU A 213
GLY A 185
SER A 254
 None
 0.57A 4b53B-1x9jA:
undetectable		 4b53B-1x9jA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 10 TYR A 173
HIS A 192
VAL A 300
ILE A 299
LEU A 292
 None
 1.49A 4jtqA-1x9jA:
undetectable		 4jtqA-1x9jA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_B_FLPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 9 TYR A 173
HIS A 192
VAL A 300
ILE A 299
LEU A 292
 None
 1.49A 4jtqB-1x9jA:
0.3		 4jtqB-1x9jA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 12 SER A  17
GLY A  10
ARG A  74
GLY A  75
LEU A 338
 None
None
GOL  A 395 ( 4.6A)
None
None
 1.01A 4uinH-1x9jA:
undetectable
4uinL-1x9jA:
undetectable		 4uinH-1x9jA:
19.21
4uinL-1x9jA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		3 / 3 ASP A 297
VAL A 165
LEU A 327
 None
 0.32A 5e5jB-1x9jA:
undetectable		 5e5jB-1x9jA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		3 / 3 GLY A  83
ASP A 128
ASN A 157
 None
 0.60A 5jglA-1x9jA:
undetectable		 5jglA-1x9jA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 12 SER A 106
ALA A 113
TYR A 355
ALA A 110
GLY A 109
 None
 1.02A 5tzoA-1x9jA:
undetectable		 5tzoA-1x9jA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 12 SER A 106
ALA A 113
TYR A 355
ALA A 110
GLY A 109
 None
 1.10A 5tzoB-1x9jA:
undetectable		 5tzoB-1x9jA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		5 / 12 SER A 106
ALA A 113
TYR A 355
ALA A 110
GLY A 109
 None
 1.03A 5tzoC-1x9jA:
undetectable		 5tzoC-1x9jA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		4 / 8 VAL A 126
LEU A  78
TYR A 355
ILE A  93
 None
 0.91A 5y1yA-1x9jA:
undetectable		 5y1yA-1x9jA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 1x9j PROBABLE BUTYRATE
KINASE 2
(Thermotoga
maritima) 		4 / 6 GLU A 164
GLU A 334
ALA A 337
LYS A 336
 None
 1.02A 6an0A-1x9jA:
0.7		 6an0A-1x9jA:
21.70