SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 8 GLN A 886
PRO A 884
GLU A 880
ASP A 881
 None
 1.19A 1dtlA-1x9nA:
undetectable		 1dtlA-1x9nA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 8 PHE A 616
THR A 620
LEU A 657
VAL A 584
 None
 0.98A 1iwiA-1x9nA:
undetectable		 1iwiA-1x9nA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 11 LEU A 796
LEU A 759
ALA A 858
VAL A 844
TYR A 855
 None
 1.21A 1kt7A-1x9nA:
undetectable		 1kt7A-1x9nA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 12 LEU A 513
LEU A 312
LEU A 327
LEU A 316
LEU A 328
 None
 1.07A 1mx1C-1x9nA:
undetectable		 1mx1C-1x9nA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 THR A 506
GLU A 734
ASP A 730
 None
 0.76A 1nt2A-1x9nA:
undetectable		 1nt2A-1x9nA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 ALA A 321
VAL A 319
TRP A 281
 None
 0.80A 1nt5A-1x9nA:
undetectable		 1nt5A-1x9nA:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 ALA A 321
VAL A 319
TRP A 281
 None
 0.80A 1nt5B-1x9nA:
undetectable		 1nt5B-1x9nA:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 7 LEU A 618
PHE A 693
LEU A 682
SER A 612
 None
 1.05A 1wrlE-1x9nA:
undetectable
1wrlF-1x9nA:
undetectable		 1wrlE-1x9nA:
8.16
1wrlF-1x9nA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 12 THR A 620
ALA A 696
ILE A 576
ILE A 605
LEU A 682
 None
 1.14A 2rlcA-1x9nA:
undetectable		 2rlcA-1x9nA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 5 ILE A 602
PRO A 606
VAL A 671
PHE A 686
 None
 1.02A 2ygnA-1x9nA:
undetectable		 2ygnA-1x9nA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 ASP A 730
THR A 506
GLU A 734
 None
 0.73A 2zifB-1x9nA:
undetectable		 2zifB-1x9nA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 12 GLN A 465
SER A 468
LEU A 520
LEU A 331
LEU A 496
 None
 1.40A 3adxA-1x9nA:
0.0		 3adxA-1x9nA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 PRO A 518
LEU A 328
ARG A 409
 None
 0.69A 3aqiA-1x9nA:
undetectable		 3aqiA-1x9nA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 6 VAL A 276
LEU A 521
ALA A 321
LEU A 322
 None
 0.91A 3kk6B-1x9nA:
undetectable		 3kk6B-1x9nA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 12 PHE A 660
GLY A 571
ALA A 622
ILE A 576
ILE A 617
 None
 1.10A 3ld6A-1x9nA:
undetectable		 3ld6A-1x9nA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 10 VAL A 349
ILE A 427
ALA A 359
THR A 362
VAL A 379
 None
 0.94A 3me6A-1x9nA:
undetectable		 3me6A-1x9nA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 TYR A 273
TYR A 266
GLU A 277
 None
 0.75A 3pfgA-1x9nA:
undetectable		 3pfgA-1x9nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		6 / 12 GLU A 566
LYS A 568
ARG A 589
GLU A 621
LYS A 725
LYS A 744
 None
 0.91A 3qwuA-1x9nA:
11.1		 3qwuA-1x9nA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		6 / 12 GLU A 566
LYS A 568
GLU A 621
PHE A 660
LYS A 725
LYS A 744
 None
 0.82A 3qwuA-1x9nA:
11.1		 3qwuA-1x9nA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 11 GLU A 566
LYS A 568
ARG A 589
GLU A 621
LYS A 725
 None
 0.86A 3qwuB-1x9nA:
6.0		 3qwuB-1x9nA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 11 GLU A 566
LYS A 568
GLU A 621
PHE A 660
LYS A 725
 None
 0.67A 3qwuB-1x9nA:
6.0		 3qwuB-1x9nA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 6 ILE A 516
LEU A 503
GLU A 509
ALA A 736
 None
 0.87A 3r9sA-1x9nA:
undetectable		 3r9sA-1x9nA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 ARG A 678
THR A 726
TRP A 742
 None
 1.26A 4d7hA-1x9nA:
undetectable		 4d7hA-1x9nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 11 PHE A 431
ALA A 361
ALA A 359
VAL A 349
LEU A 446
 None
 1.16A 4jbtB-1x9nA:
undetectable		 4jbtB-1x9nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 ASP A 326
LEU A 315
VAL A 276
 None
 0.67A 4jecB-1x9nA:
undetectable		 4jecB-1x9nA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 7 VAL A 893
ALA A 857
ASP A 758
LEU A 759
 None
 0.81A 4l9iA-1x9nA:
undetectable		 4l9iA-1x9nA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 12 GLY A 380
ILE A 442
ILE A 427
SER A 447
LEU A 347
 None
 1.04A 4mwzA-1x9nA:
undetectable		 4mwzA-1x9nA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 4 LEU A 338
SER A 406
LEU A 333
LEU A 347
 None
 1.03A 4n09A-1x9nA:
undetectable		 4n09A-1x9nA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 ARG A 678
THR A 726
TRP A 742
 None
 1.26A 4ug5A-1x9nA:
undetectable		 4ug5A-1x9nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 ARG A 678
THR A 726
TRP A 742
 None
 1.25A 4uglA-1x9nA:
undetectable		 4uglA-1x9nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 7 GLU A 843
LEU A 757
LEU A 870
LEU A 849
 None
 0.56A 4wg0B-1x9nA:
undetectable
4wg0C-1x9nA:
undetectable		 4wg0B-1x9nA:
2.75
4wg0C-1x9nA:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 7 LEU A 870
LEU A 849
GLU A 843
LEU A 757
 None
 0.59A 4wg0L-1x9nA:
undetectable
4wg0M-1x9nA:
undetectable		 4wg0L-1x9nA:
2.75
4wg0M-1x9nA:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 4 VAL A 554
GLU A 553
GLY A 550
LEU A 745
 None
 1.32A 5g5gC-1x9nA:
undetectable		 5g5gC-1x9nA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 ARG A 678
THR A 726
TRP A 742
 None
 1.28A 5g6cA-1x9nA:
0.0		 5g6cA-1x9nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 VAL A 510
HIS A 531
VAL A 519
 None
 0.67A 5jmnC-1x9nA:
undetectable		 5jmnC-1x9nA:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 1x9n DNA LIGASE I
(Homo
sapiens) 		3 / 3 HIS A 577
LYS A 585
PHE A 587
 None
 1.00A 5klaA-1x9nA:
undetectable		 5klaA-1x9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 12 ILE A 424
ALA A 443
SER A 447
VAL A 358
ILE A 427
 None
 1.41A 5mlmA-1x9nA:
undetectable		 5mlmA-1x9nA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 12 ALA A 840
VAL A 841
ILE A 826
ALA A 829
TYR A 855
 None
 1.03A 5n5dB-1x9nA:
undetectable		 5n5dB-1x9nA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 7 GLN A 457
LEU A 460
ALA A 466
LEU A 469
 None
 1.09A 5nwvA-1x9nA:
0.0		 5nwvA-1x9nA:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 10 LEU A 335
ILE A 516
LEU A 520
ALA A 462
LEU A 316
 None
 0.84A 5y7pB-1x9nA:
undetectable		 5y7pB-1x9nA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 10 LEU A 335
ILE A 516
LEU A 520
ALA A 462
LEU A 316
 None
 0.82A 5y7pD-1x9nA:
undetectable		 5y7pD-1x9nA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 10 LEU A 335
ILE A 516
LEU A 520
ALA A 462
LEU A 316
 None
 0.81A 5y7pH-1x9nA:
0.0		 5y7pH-1x9nA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1x9n DNA LIGASE I
(Homo
sapiens) 		5 / 12 ALA A 304
TYR A 289
ALA A 439
ALA A 443
LEU A 450
 None
 1.33A 6aycA-1x9nA:
undetectable		 6aycA-1x9nA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 6 GLY A 769
ASP A 378
ARG A 449
ARG A 444
 None
 1.22A 6dwdA-1x9nA:
undetectable
6dwdC-1x9nA:
undetectable		 6dwdA-1x9nA:
21.10
6dwdC-1x9nA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 5 GLY A 769
ASP A 378
ARG A 449
ARG A 444
 None
 1.24A 6dwdB-1x9nA:
undetectable
6dwdD-1x9nA:
undetectable		 6dwdB-1x9nA:
21.10
6dwdD-1x9nA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1x9n DNA LIGASE I
(Homo
sapiens) 		4 / 5 ARG A 449
ARG A 444
GLY A 769
ASP A 378
 None
 1.34A 6dwjB-1x9nA:
undetectable
6dwjD-1x9nA:
undetectable		 6dwjB-1x9nA:
21.10
6dwjD-1x9nA:
21.10