SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x9q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT
(Homo
sapiens) 		3 / 3 TRP A 115
ARG A  38
THR A 111
 FLU  A1341 (-4.8A)
None
None
 0.99A 1df7A-1x9qA:
undetectable		 1df7A-1x9qA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT
(Homo
sapiens) 		5 / 12 GLY A 159
LEU A 155
ASP A 156
SER A 231
PHE A 180
 None
 1.46A 2b9eA-1x9qA:
undetectable		 2b9eA-1x9qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT
(Homo
sapiens) 		5 / 12 LYS A 170
LEU A 155
ASP A 156
SER A 231
PHE A 180
 None
 1.37A 2b9eA-1x9qA:
undetectable		 2b9eA-1x9qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT
(Homo
sapiens) 		5 / 8 ASP A 101
LEU A  56
LYS A  58
GLY A 103
TYR A 105
 ACT  A1476 (-4.1A)
None
ACT  A1476 (-3.0A)
None
None
 1.50A 3af0A-1x9qA:
undetectable		 3af0A-1x9qA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT
(Homo
sapiens) 		5 / 12 VAL A 153
MET A 185
ARG A 225
VAL A 232
TYR A 258
 None
 0.72A 3qxvB-1x9qA:
13.8		 3qxvB-1x9qA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT
(Homo
sapiens) 		4 / 8 LEU A 155
MET A 185
TYR A 183
GLU A 257
 None
 1.13A 3zmdA-1x9qA:
undetectable
3zmdB-1x9qA:
undetectable		 3zmdA-1x9qA:
19.47
3zmdB-1x9qA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT
(Homo
sapiens) 		3 / 3 LEU A 259
MET A 185
TYR A 247
 None
 0.75A 4p6xG-1x9qA:
undetectable		 4p6xG-1x9qA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT
(Homo
sapiens) 		3 / 3 TYR A 213
GLY A 219
THR A 222
 None
 0.11A 6cjkB-1x9qA:
19.3		 6cjkB-1x9qA:
25.53