SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 8 TRP A 684
GLY A 595
SER A 616
PHE A 487
 None
 0.80A 1ax9A-1x9sA:
undetectable		 1ax9A-1x9sA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 7 LEU A 479
LEU A 481
TYR A 530
LEU A 614
 None
 0.97A 1kt3A-1x9sA:
undetectable		 1kt3A-1x9sA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 ILE A 621
LEU A 624
TRP A 651
LEU A 223
ILE A 627
 None
 1.27A 1kyvC-1x9sA:
undetectable
1kyvD-1x9sA:
undetectable		 1kyvC-1x9sA:
13.74
1kyvD-1x9sA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 ILE A 621
LEU A 624
TRP A 651
LEU A 223
ILE A 627
 None
 1.26A 1kyvD-1x9sA:
undetectable
1kyvE-1x9sA:
undetectable		 1kyvD-1x9sA:
13.74
1kyvE-1x9sA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 7 GLN A 615
GLU A 480
PHE A 555
ALA A 608
 None
 0.99A 1linA-1x9sA:
undetectable		 1linA-1x9sA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 11 LEU A  69
GLY A  21
SER A   4
VAL A  32
LEU A  43
 None
 1.10A 1mx1A-1x9sA:
undetectable		 1mx1A-1x9sA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 8 GLU A 630
VAL A 634
HIS A  62
GLU A  86
 None
 1.23A 1s3zA-1x9sA:
undetectable
1s3zB-1x9sA:
undetectable		 1s3zA-1x9sA:
12.61
1s3zB-1x9sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 7 SER A 338
ILE A 383
ILE A 386
LYS A 387
 None
 0.90A 1sbrB-1x9sA:
3.5		 1sbrB-1x9sA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 VAL A   3
LEU A 186
SER A  95
HIS A 218
PHE A 192
 None
 1.44A 1skxA-1x9sA:
0.0		 1skxA-1x9sA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 LEU A 283
HIS A 276
LYS A 281
 None
 0.95A 1y7iA-1x9sA:
undetectable		 1y7iA-1x9sA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 7 TRP A 684
GLY A 595
SER A 616
PHE A 487
 None
 0.81A 2ackA-1x9sA:
undetectable		 2ackA-1x9sA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_A_ADNA901_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 10 PHE A 234
HIS A 459
TRP A 406
ILE A 416
ASN A 699
 None
 1.49A 2gl0A-1x9sA:
3.7
2gl0B-1x9sA:
3.6		 2gl0A-1x9sA:
14.58
2gl0B-1x9sA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 11 PHE A 234
HIS A 459
TRP A 406
ILE A 416
ASN A 699
 None
 1.48A 2gl0B-1x9sA:
3.6
2gl0C-1x9sA:
3.8		 2gl0B-1x9sA:
14.58
2gl0C-1x9sA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 PHE A 234
HIS A 459
TRP A 406
ILE A 416
ASN A 699
 None
 1.41A 2gl0D-1x9sA:
3.7
2gl0E-1x9sA:
3.9		 2gl0D-1x9sA:
14.58
2gl0E-1x9sA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 LEU A 620
GLY A 595
VAL A 426
ALA A 609
LEU A 610
 None
 1.14A 2oz7A-1x9sA:
undetectable		 2oz7A-1x9sA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 LEU A 346
LEU A 390
PHE A 261
 None
 0.53A 2pgrA-1x9sA:
undetectable		 2pgrA-1x9sA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 7 ILE A 500
LEU A 614
LEU A 479
GLY A 478
 None
 0.98A 2qqcD-1x9sA:
1.2
2qqcE-1x9sA:
undetectable		 2qqcD-1x9sA:
10.42
2qqcE-1x9sA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 8 LEU A 246
LEU A 242
LEU A 407
ALA A 405
 None
 0.88A 2vcvF-1x9sA:
undetectable		 2vcvF-1x9sA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 8 LEU A 610
ILE A 569
LEU A 565
LEU A 614
 None
 0.79A 2xfhA-1x9sA:
undetectable		 2xfhA-1x9sA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 8 GLY A 428
THR A 427
GLY A 424
ALA A 425
GLU A 480
 None
 1.35A 3aruA-1x9sA:
undetectable		 3aruA-1x9sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 11 ILE A 656
LEU A 223
ALA A 220
ILE A 621
MET A 677
 None
 1.11A 3b2rB-1x9sA:
undetectable		 3b2rB-1x9sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 11 ILE A 656
LEU A 223
ALA A 220
ILE A 627
MET A 677
 None
 1.11A 3b2rB-1x9sA:
undetectable		 3b2rB-1x9sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 TYR A  64
ASP A   5
HIS A  19
 None
MG  A3001 (-3.2A)
None
 0.61A 3e23A-1x9sA:
undetectable		 3e23A-1x9sA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 ASP A  65
LEU A  69
GLN A  76
 MG  A3001 ( 4.0A)
None
None
 0.81A 3g4lA-1x9sA:
undetectable		 3g4lA-1x9sA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 LEU A 246
GLY A 397
ALA A 400
SER A 399
LEU A 407
 None
 1.12A 3n8xA-1x9sA:
1.1		 3n8xA-1x9sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 LEU A 481
LEU A 484
ALA A 485
GLY A 503
LEU A 501
 None
 0.93A 3olsA-1x9sA:
undetectable		 3olsA-1x9sA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 6 ILE A 505
GLU A 499
ALA A 497
ASN A 502
 None
 1.08A 3pgyA-1x9sA:
undetectable
3pgyB-1x9sA:
undetectable		 3pgyA-1x9sA:
21.32
3pgyB-1x9sA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 LEU A 481
LEU A 484
ALA A 485
GLY A 503
LEU A 501
 None
 0.79A 3q95B-1x9sA:
undetectable		 3q95B-1x9sA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 9 PHE A 206
LEU A 182
THR A 178
LEU A  55
ILE A  89
 None
 1.10A 3tbgD-1x9sA:
undetectable		 3tbgD-1x9sA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 GLN A 266
ASP A 340
GLN A 343
 None
 0.78A 4aztA-1x9sA:
undetectable		 4aztA-1x9sA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 GLU A 126
GLY A 129
SER A  95
 None
 0.71A 4b53B-1x9sA:
undetectable		 4b53B-1x9sA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 5 LEU A 515
ILE A 525
ALA A 512
PHE A 555
 None
 0.82A 4dc3B-1x9sA:
undetectable		 4dc3B-1x9sA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 LEU A  83
LEU A  69
LEU A  72
ALA A  73
GLN A  76
 None
 0.88A 4fn9B-1x9sA:
undetectable		 4fn9B-1x9sA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 4 VAL A 470
THR A 662
GLU A 663
GLU A 664
 None
 1.30A 4l78A-1x9sA:
4.0		 4l78A-1x9sA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 LEU A  83
LEU A  69
LEU A  72
ALA A  73
GLN A  76
 None
 0.89A 4ltwA-1x9sA:
undetectable		 4ltwA-1x9sA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 8 TYR A  34
ILE A  23
LYS A   1
ALA A  48
 None
 0.98A 4ou1A-1x9sA:
undetectable		 4ou1A-1x9sA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 LEU A 481
LEU A 484
ALA A 485
GLY A 503
LEU A 501
 None
 0.79A 4pxmA-1x9sA:
undetectable		 4pxmA-1x9sA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 9 ALA A  48
ALA A  45
GLY A  53
GLY A  54
ASP A  25
 None
 0.86A 4qwuK-1x9sA:
undetectable
4qwuL-1x9sA:
undetectable		 4qwuK-1x9sA:
14.04
4qwuL-1x9sA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 9 ALA A  48
ALA A  45
GLY A  53
GLY A  54
ASP A  25
 None
 0.83A 4qwuY-1x9sA:
undetectable
4qwuZ-1x9sA:
undetectable		 4qwuY-1x9sA:
14.04
4qwuZ-1x9sA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		4 / 6 LEU A 484
LEU A 481
GLU A 480
ILE A 525
 None
 0.74A 4ww7A-1x9sA:
undetectable		 4ww7A-1x9sA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 GLU A   7
VAL A  22
THR A 178
SER A  95
GLY A 129
 None
 1.50A 4ydqB-1x9sA:
undetectable		 4ydqB-1x9sA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 LEU A 385
PHE A 261
ILE A 386
 None
 0.73A 5dzk1-1x9sA:
undetectable
5dzkF-1x9sA:
undetectable
5dzkM-1x9sA:
undetectable		 5dzk1-1x9sA:
16.67
5dzkF-1x9sA:
15.71
5dzkM-1x9sA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 VAL A 669
GLN A 471
CYH A 660
 None
 0.72A 5icxA-1x9sA:
undetectable
5icxE-1x9sA:
undetectable		 5icxA-1x9sA:
15.32
5icxE-1x9sA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 VAL A 669
GLN A 471
CYH A 660
 None
 0.83A 5icxC-1x9sA:
0.0
5icxF-1x9sA:
undetectable		 5icxC-1x9sA:
15.32
5icxF-1x9sA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 ILE A 562
GLU A 480
PHE A 524
ALA A 513
ILE A 500
 None
 1.13A 5ih0A-1x9sA:
undetectable		 5ih0A-1x9sA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 12 ILE A 562
GLU A 480
PHE A 524
ALA A 513
ILE A 500
 None
 1.17A 5iwuA-1x9sA:
undetectable		 5iwuA-1x9sA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		5 / 7 LEU A  12
SER A  14
LEU A  72
THR A  70
ALA A  68
 None
 1.42A 5o96C-1x9sA:
undetectable		 5o96C-1x9sA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 VAL A 329
TYR A 265
GLN A 266
 None
 0.67A 5qgkA-1x9sA:
undetectable		 5qgkA-1x9sA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 VAL A 329
TYR A 265
GLN A 266
 None
 0.63A 5qgrA-1x9sA:
undetectable		 5qgrA-1x9sA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1x9s DNA POLYMERASE
(Escherichia
virus
T7) 		3 / 3 VAL A 329
TYR A 265
GLN A 266
 None
 0.68A 5qgtA-1x9sA:
undetectable		 5qgtA-1x9sA:
14.58