SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		5 / 8 PHE A  88
ILE A  90
PHE A 141
LEU A 146
VAL A 158
 None
 1.38A 1fslA-1x9yA:
undetectable		 1fslA-1x9yA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		3 / 3 HIS A 340
ASP A 383
ASN A 121
 None
 0.80A 1wg8B-1x9yA:
undetectable		 1wg8B-1x9yA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		4 / 6 LEU A 228
ASN A 310
GLN A 303
ILE A 322
 None
 1.09A 2jn3A-1x9yA:
undetectable		 2jn3A-1x9yA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		3 / 3 ASN A 240
LEU A 279
HIS A 264
 None
 0.68A 2q6fB-1x9yA:
1.2		 2q6fB-1x9yA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		5 / 11 THR A  79
ALA A  65
GLY A  66
ALA A  68
PHE A  64
 None
 1.43A 2xh9A-1x9yA:
2.1		 2xh9A-1x9yA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		5 / 10 THR A  79
ALA A  65
GLY A  66
ALA A  68
PHE A  64
 None
 1.42A 2xh9B-1x9yA:
2.2		 2xh9B-1x9yA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		4 / 8 SER A 367
ASP A  72
ASP A 363
ASP A 145
 None
 1.10A 3havA-1x9yA:
undetectable		 3havA-1x9yA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		4 / 8 SER A 374
ASP A 124
ASP A 372
ASP A 370
 None
 1.27A 3n2oC-1x9yA:
undetectable
3n2oD-1x9yA:
undetectable		 3n2oC-1x9yA:
22.08
3n2oD-1x9yA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		4 / 4 GLY A 392
GLY A 321
THR A 255
LEU A 252
 None
 0.86A 3si7C-1x9yA:
undetectable
3si7D-1x9yA:
undetectable		 3si7C-1x9yA:
21.54
3si7D-1x9yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		4 / 4 PRO A 208
LEU A 146
ILE A 149
ARG A 174
 None
 1.21A 4f4dA-1x9yA:
undetectable		 4f4dA-1x9yA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		3 / 3 TYR A 384
ARG A 382
SER A 328
 None
 1.09A 4khpI-1x9yA:
undetectable
4khpJ-1x9yA:
undetectable		 4khpI-1x9yA:
14.01
4khpJ-1x9yA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		4 / 8 THR A 179
GLU A 187
ASN A 183
GLY A 164
 None
 0.90A 4r3aA-1x9yA:
undetectable		 4r3aA-1x9yA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		4 / 7 GLY A  66
GLN A  63
ALA A  70
ILE A 368
 None
 0.72A 4txnA-1x9yA:
undetectable		 4txnA-1x9yA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		4 / 7 GLY A  66
GLN A  63
ALA A  70
ILE A 368
 None
 0.76A 4txnB-1x9yA:
undetectable		 4txnB-1x9yA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		4 / 7 GLY A  66
GLN A  63
ALA A  70
ILE A 368
 None
 0.74A 4txnC-1x9yA:
undetectable		 4txnC-1x9yA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		4 / 7 GLY A  66
GLN A  63
ALA A  70
ILE A 368
 None
 0.74A 4txnD-1x9yA:
undetectable		 4txnD-1x9yA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		5 / 12 GLU A 162
ASP A 161
LEU A 159
GLY A  95
GLU A 168
 None
 1.15A 4xe5A-1x9yA:
undetectable		 4xe5A-1x9yA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		5 / 12 ILE A 350
GLY A  66
VAL A 105
ALA A  70
ALA A 348
 None
 1.03A 5n0oB-1x9yA:
undetectable		 5n0oB-1x9yA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		5 / 12 ILE A 350
GLY A  66
VAL A 105
ALA A  70
ALA A 348
 None
 1.04A 5n0tB-1x9yA:
undetectable		 5n0tB-1x9yA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		3 / 3 ASP A 124
ASN A 121
ASP A 372
 None
 0.77A 5vopA-1x9yA:
undetectable		 5vopA-1x9yA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 1x9y CYSTEINE PROTEINASE
(Staphylococcus
aureus) 		4 / 5 ASN A 184
TYR A 384
VAL A 329
SER A 379
 None
 1.22A 6a7pA-1x9yA:
undetectable		 6a7pA-1x9yA:
21.54