SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xa6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 1.04A 1jffB-1xa6A:
undetectable		 1jffB-1xa6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 9 LEU A 404
VAL A 455
VAL A 428
GLY A 426
LEU A 401
 None
 1.23A 1lwfA-1xa6A:
undetectable		 1lwfA-1xa6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		3 / 3 LEU A 383
VAL A 386
LEU A 390
 None
 0.52A 1mz9B-1xa6A:
undetectable		 1mz9B-1xa6A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 LEU A 236
THR A 219
ASP A 127
THR A 131
GLY A 240
 None
 1.39A 1v8bA-1xa6A:
undetectable		 1v8bA-1xa6A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 LEU A 236
THR A 219
ASP A 127
THR A 131
GLY A 240
 None
 1.40A 1v8bB-1xa6A:
undetectable		 1v8bB-1xa6A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 LEU A 236
THR A 219
ASP A 127
THR A 131
GLY A 240
 None
 1.37A 1v8bD-1xa6A:
undetectable		 1v8bD-1xa6A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 9 LEU A 404
VAL A 455
VAL A 428
GLY A 426
LEU A 401
 None
 1.39A 1vrtA-1xa6A:
0.0		 1vrtA-1xa6A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		4 / 8 LEU A 433
ILE A 362
LEU A 458
ILE A 459
 None
 0.79A 2azxA-1xa6A:
undetectable		 2azxA-1xa6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 LEU A 433
LEU A 404
MET A 405
LEU A 309
VAL A 411
 None
 1.17A 2hrcB-1xa6A:
undetectable		 2hrcB-1xa6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 1.04A 2hxfB-1xa6A:
undetectable		 2hxfB-1xa6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 1.04A 2hxhB-1xa6A:
undetectable		 2hxhB-1xa6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 1.04A 2p4nB-1xa6A:
undetectable		 2p4nB-1xa6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 11 LEU A 433
LEU A 404
MET A 405
LEU A 309
VAL A 411
 None
 1.34A 2po5B-1xa6A:
undetectable		 2po5B-1xa6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 LEU A 433
LEU A 404
MET A 405
LEU A 309
VAL A 411
 None
 1.29A 2qd4B-1xa6A:
undetectable		 2qd4B-1xa6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		4 / 6 LEU A 266
ASP A 265
ILE A 269
ARG A 268
 None
 0.93A 2rlfA-1xa6A:
undetectable
2rlfB-1xa6A:
undetectable		 2rlfA-1xa6A:
8.57
2rlfB-1xa6A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 1.04A 2wbeB-1xa6A:
undetectable		 2wbeB-1xa6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		3 / 3 LEU A  28
TYR A  27
GLN A  30
 None
 0.73A 2wekA-1xa6A:
undetectable		 2wekA-1xa6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 1.04A 3dcoB-1xa6A:
undetectable		 3dcoB-1xa6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 1.03A 3edlB-1xa6A:
undetectable		 3edlB-1xa6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 11 THR A 443
LEU A 453
ILE A 371
TYR A 367
GLN A 451
 None
 1.50A 3elzB-1xa6A:
0.6		 3elzB-1xa6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 1.02A 3iz0B-1xa6A:
undetectable		 3iz0B-1xa6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 LEU A 458
THR A 366
ILE A 362
LEU A 401
LEU A 390
 None
 1.11A 3k2hA-1xa6A:
undetectable		 3k2hA-1xa6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		4 / 6 PHE A 466
TYR A 398
HIS A 387
VAL A 386
 None
 1.30A 3lb3A-1xa6A:
0.0		 3lb3A-1xa6A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		4 / 6 PHE A 466
TYR A 398
HIS A 387
VAL A 386
 None
 1.17A 3lb3B-1xa6A:
0.0		 3lb3B-1xa6A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		3 / 3 GLY A 308
ILE A 427
VAL A 428
 None
 0.29A 3nv6A-1xa6A:
undetectable		 3nv6A-1xa6A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		4 / 6 ILE A 150
TRP A 234
ILE A 134
TRP A 225
 None
 1.15A 3welA-1xa6A:
undetectable		 3welA-1xa6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		3 / 3 TYR A 228
THR A 146
GLU A 152
 None
 0.78A 4df3A-1xa6A:
undetectable		 4df3A-1xa6A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		3 / 3 TYR A 228
THR A 146
GLU A 152
 None
 0.78A 4df3B-1xa6A:
undetectable		 4df3B-1xa6A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 LEU A 248
ASN A 249
PHE A 220
GLY A 240
SER A 255
 None
 1.37A 4ot2A-1xa6A:
undetectable		 4ot2A-1xa6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		4 / 6 TYR A 103
GLU A 135
THR A 131
LEU A 101
 None
 1.34A 4qzuC-1xa6A:
undetectable		 4qzuC-1xa6A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 LEU A 248
ASN A 249
PHE A 220
GLY A 240
SER A 255
 None
 1.34A 4zbrA-1xa6A:
undetectable		 4zbrA-1xa6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 0.99A 5hnwB-1xa6A:
undetectable		 5hnwB-1xa6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 411
LEU A 401
PHE A 429
LEU A 433
ARG A 288
 None
 1.06A 5hnyB-1xa6A:
undetectable		 5hnyB-1xa6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		4 / 8 ILE A 343
GLY A 308
LEU A 425
LEU A 408
 None
 0.81A 5hs1A-1xa6A:
undetectable		 5hs1A-1xa6A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		4 / 5 ILE A  79
ILE A 121
HIS A 122
VAL A 125
 None
 1.00A 5jmnA-1xa6A:
undetectable		 5jmnA-1xa6A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 LEU A 236
THR A 219
ASP A 127
THR A 131
GLY A 240
 None
 1.44A 5m66A-1xa6A:
undetectable		 5m66A-1xa6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		4 / 8 ILE A  42
PRO A  44
THR A  91
TYR A  90
 None
 0.86A 6cduD-1xa6A:
undetectable
6cduE-1xa6A:
1.7		 6cduD-1xa6A:
20.21
6cduE-1xa6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		4 / 8 ILE A 335
VAL A 322
ALA A 349
TYR A 353
 None
 0.81A 6cduD-1xa6A:
undetectable
6cduE-1xa6A:
1.7		 6cduD-1xa6A:
20.21
6cduE-1xa6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 411
LEU A 401
PHE A 429
LEU A 433
LEU A 350
 None
 1.19A 6ew0G-1xa6A:
undetectable		 6ew0G-1xa6A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 1xa6 BETA2-CHIMAERIN
(Homo
sapiens) 		4 / 5 LEU A 236
THR A 126
THR A 131
GLY A 128
 None
 1.02A 6gtqA-1xa6A:
undetectable		 6gtqA-1xa6A:
17.31