SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 9 PHE A 242
THR A 252
LEU A 335
VAL A 341
GLY A 330
 None
 1.50A 1dz8B-1xapA:
undetectable		 1dz8B-1xapA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 9 PHE A 242
THR A 252
LEU A 335
VAL A 341
GLY A 330
 None
 1.50A 1dz9B-1xapA:
undetectable		 1dz9B-1xapA:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		10 / 12 PHE A 221
ALA A 225
CYH A 228
LEU A 259
LEU A 262
ILE A 263
ILE A 266
ARG A 269
SER A 280
PHE A 295
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 ( 3.8A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
 0.46A 1xdkB-1xapA:
37.1		 1xdkB-1xapA:
92.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		3 / 3 LEU A 224
PHE A 279
ARG A 387
 TTB  A   1 (-4.4A)
TTB  A   1 (-4.6A)
None
 0.19A 1xdkB-1xapA:
37.1		 1xdkB-1xapA:
92.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		6 / 12 PHE A 221
ALA A 225
ARG A 269
SER A 280
PHE A 295
LEU A 298
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
None
 0.63A 1xdkF-1xapA:
37.1		 1xdkF-1xapA:
92.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		10 / 12 PHE A 221
ALA A 225
CYH A 228
LEU A 259
LEU A 262
ILE A 263
ILE A 266
ARG A 269
SER A 280
PHE A 295
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 ( 3.8A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
 0.46A 1xdkF-1xapA:
37.1		 1xdkF-1xapA:
92.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		3 / 3 LEU A 224
PHE A 279
ARG A 387
 TTB  A   1 (-4.4A)
TTB  A   1 (-4.6A)
None
 0.21A 1xdkF-1xapA:
37.1		 1xdkF-1xapA:
92.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		3 / 3 ARG A 269
VAL A 302
GLY A 294
 TTB  A   1 (-3.3A)
None
None
 0.61A 2avvE-1xapA:
undetectable		 2avvE-1xapA:
17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		10 / 12 PHE A 221
LYS A 227
CYH A 228
LEU A 262
ARG A 265
ILE A 266
ARG A 269
PHE A 279
SER A 280
LEU A 391
 TTB  A   1 (-4.7A)
None
TTB  A   1 ( 3.8A)
TTB  A   1 (-3.9A)
None
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-4.6A)
TTB  A   1 (-3.1A)
None
 0.53A 2lbdA-1xapA:
38.3		 2lbdA-1xapA:
87.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		9 / 12 PHE A 221
LYS A 227
CYH A 228
LEU A 262
ARG A 265
PHE A 279
SER A 280
GLY A 384
LEU A 391
 TTB  A   1 (-4.7A)
None
TTB  A   1 ( 3.8A)
TTB  A   1 (-3.9A)
None
TTB  A   1 (-4.6A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.0A)
None
 0.65A 2lbdA-1xapA:
38.3		 2lbdA-1xapA:
87.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 9 PHE A 192
GLU A 190
GLY A 320
GLU A 182
ILE A 184
 None
 1.34A 2w98A-1xapA:
undetectable		 2w98A-1xapA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 11 ILE A 266
ARG A 269
PHE A 279
SER A 280
LEU A 213
 TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-4.6A)
TTB  A   1 (-3.1A)
None
 1.30A 3a9eB-1xapA:
37.2		 3a9eB-1xapA:
81.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		10 / 11 PHE A 221
CYH A 228
LEU A 262
ILE A 266
ARG A 269
PHE A 279
SER A 280
PHE A 295
VAL A 388
LEU A 391
 TTB  A   1 (-4.7A)
TTB  A   1 ( 3.8A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-4.6A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
TTB  A   1 (-4.3A)
None
 0.49A 3a9eB-1xapA:
37.2		 3a9eB-1xapA:
81.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		9 / 12 PHE A 221
ALA A 225
LEU A 259
LEU A 262
ILE A 266
ARG A 269
SER A 280
PHE A 295
ILE A 403
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
TTB  A   1 ( 4.8A)
 0.34A 3lbdA-1xapA:
38.2		 3lbdA-1xapA:
87.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		7 / 12 PHE A 221
ALA A 225
LEU A 259
LEU A 262
SER A 280
GLY A 384
ILE A 403
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.0A)
TTB  A   1 ( 4.8A)
 0.69A 3lbdA-1xapA:
38.2		 3lbdA-1xapA:
87.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 12 GLY A 241
GLU A 337
LEU A 239
THR A 246
LEU A 245
 None
 1.05A 3mteB-1xapA:
undetectable		 3mteB-1xapA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		11 / 11 PHE A 221
CYH A 228
LEU A 259
LEU A 262
ILE A 263
ARG A 269
PHE A 279
SER A 280
LEU A 298
LEU A 391
ILE A 403
 TTB  A   1 (-4.7A)
TTB  A   1 ( 3.8A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.3A)
TTB  A   1 (-4.6A)
TTB  A   1 (-3.1A)
None
None
TTB  A   1 ( 4.8A)
 0.48A 4dm8A-1xapA:
38.3		 4dm8A-1xapA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		8 / 12 PHE A 192
LEU A 224
LEU A 259
ILE A 263
ARG A 269
SER A 280
PHE A 295
LEU A 391
 None
TTB  A   1 (-4.4A)
TTB  A   1 ( 4.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
None
 0.78A 4dm8B-1xapA:
38.2		 4dm8B-1xapA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		11 / 12 PHE A 221
LEU A 224
ALA A 225
LEU A 259
LEU A 262
ILE A 263
ARG A 269
SER A 280
PHE A 295
GLY A 384
LEU A 391
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.4A)
TTB  A   1 (-4.0A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
TTB  A   1 ( 4.0A)
None
 0.65A 4dm8B-1xapA:
38.2		 4dm8B-1xapA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		4 / 8 PHE A 305
THR A 319
ASP A 315
ASP A 316
 None
 1.29A 4qb9D-1xapA:
undetectable		 4qb9D-1xapA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		4 / 4 THR A 203
GLY A 216
ASP A 219
SER A 205
 None
 1.36A 4rfqA-1xapA:
undetectable		 4rfqA-1xapA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		3 / 3 MET A 314
GLU A 318
LEU A 322
 None
 0.34A 4v2oB-1xapA:
1.0		 4v2oB-1xapA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		4 / 7 GLU A 318
LEU A 322
LEU A 264
LEU A 377
 None
 0.80A 4wg0B-1xapA:
undetectable
4wg0C-1xapA:
undetectable		 4wg0B-1xapA:
5.65
4wg0C-1xapA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		4 / 7 LEU A 264
LEU A 377
GLU A 318
LEU A 322
 None
 0.83A 4wg0L-1xapA:
undetectable
4wg0M-1xapA:
undetectable		 4wg0L-1xapA:
5.65
4wg0M-1xapA:
5.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		11 / 12 TRP A 218
PHE A 221
ALA A 225
LEU A 262
ILE A 266
ARG A 269
SER A 280
PHE A 295
GLY A 384
LEU A 391
ILE A 403
 None
TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
TTB  A   1 ( 4.0A)
None
TTB  A   1 ( 4.8A)
 0.74A 5m24A-1xapA:
38.4		 5m24A-1xapA:
86.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		11 / 12 PHE A 221
ALA A 225
CYH A 228
LEU A 259
LEU A 262
ILE A 263
ILE A 266
PHE A 279
SER A 280
PHE A 295
VAL A 388
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 ( 3.8A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-4.6A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
TTB  A   1 (-4.3A)
 0.54A 5uanB-1xapA:
37.1		 5uanB-1xapA:
73.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 12 ALA A 187
ARG A 185
PHE A 235
GLY A 320
ILE A 325
 None
 1.18A 5ul4A-1xapA:
undetectable		 5ul4A-1xapA:
16.40