SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  68
ALA A  69
ILE A 137
GLY A 138
ILE A  65
 None
 0.73A 1hxbA-1xatA:
undetectable		 1hxbA-1xatA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 151
VAL A 131
ILE A 137
GLY A 138
GLY A 154
 None
 1.06A 1k6cA-1xatA:
undetectable		 1k6cA-1xatA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  47
VAL A  58
ILE A  59
ILE A 119
PHE A  40
 None
 1.43A 1q6iA-1xatA:
undetectable		 1q6iA-1xatA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  68
ALA A  69
ILE A 137
GLY A 138
ILE A  65
 None
 0.81A 2avvD-1xatA:
undetectable		 2avvD-1xatA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  40
ALA A  44
ARG A  45
LEU A  57
 None
 1.17A 2bxkA-1xatA:
undetectable		 2bxkA-1xatA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 141
ALA A  69
GLY A  68
GLY A 120
ILE A 119
 None
 1.12A 2v7bA-1xatA:
undetectable		 2v7bA-1xatA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 141
ALA A  69
GLY A  68
GLY A 120
ILE A 119
 None
 1.14A 2v7bB-1xatA:
undetectable		 2v7bB-1xatA:
17.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A  11
TYR A  30
SER A  32
 None
 0.23A 2xatA-1xatA:
28.7		 2xatA-1xatA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 129
ARG A  45
ILE A  65
THR A 144
 None
 1.41A 3cl9A-1xatA:
undetectable		 3cl9A-1xatA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  68
ALA A  69
ILE A 137
GLY A 138
ILE A  65
 None
 0.82A 3cyxB-1xatA:
undetectable		 3cyxB-1xatA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 153
GLY A 120
SER A 139
ALA A 141
ILE A  59
 None
 0.98A 3mb5A-1xatA:
undetectable		 3mb5A-1xatA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 PRO A 107
GLY A  78
TYR A 105
GLY A 128
ALA A 108
 None
 1.49A 3pp7B-1xatA:
undetectable		 3pp7B-1xatA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 141
ALA A  69
GLY A  68
GLY A 120
ILE A 119
 None
 1.12A 4eatB-1xatA:
undetectable		 4eatB-1xatA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 ILE A  59
ILE A 119
ALA A  69
VAL A  18
 None
 0.70A 4jltA-1xatA:
undetectable		 4jltA-1xatA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 THR A 111
VAL A 143
VAL A 117
ILE A 119
 None
 1.01A 4l4cB-1xatA:
undetectable		 4l4cB-1xatA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 150
ILE A 113
GLY A 114
VAL A 117
ILE A 137
 None
 1.06A 4rvdA-1xatA:
undetectable		 4rvdA-1xatA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1xat XENOBIOTIC
ACETYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 165
ASP A 169
ILE A 198
GLY A 196
 None
 1.16A 4zxiA-1xatA:
undetectable		 4zxiA-1xatA:
10.02