SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xb2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		5 / 9 GLU B 117
SER B 142
GLY B 245
CYH B 328
GLY B 121
 None
 1.22A 1bcuH-1xb2B:
undetectable		 1bcuH-1xb2B:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 VAL B 230
CYH B 328
GLY B 248
LEU B 244
 None
 0.91A 1jlbA-1xb2B:
undetectable		 1jlbA-1xb2B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		5 / 8 ILE B 120
GLY B 121
LEU B 242
LEU B 239
PHE B 147
 None
 1.39A 2vctC-1xb2B:
undetectable		 2vctC-1xb2B:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 LEU B 297
CYH B 253
THR B 255
LEU B 265
VAL B 313
 None
 1.25A 3sp9A-1xb2B:
undetectable		 3sp9A-1xb2B:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 LEU B 297
CYH B 253
THR B 255
LEU B 265
VAL B 313
 None
 1.29A 3sp9B-1xb2B:
undetectable		 3sp9B-1xb2B:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 LEU B 297
VAL B 320
CYH B 253
THR B 255
LEU B 265
 None
 1.16A 3sp9B-1xb2B:
undetectable		 3sp9B-1xb2B:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		4 / 8 THR B  70
GLU B 102
LEU B  81
GLY B  71
 None
 0.90A 4r3aA-1xb2B:
undetectable		 4r3aA-1xb2B:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		4 / 9 CYH B 136
ALA B 202
LEU B 212
ILE B 211
 None
 0.92A 4xtaA-1xb2B:
undetectable		 4xtaA-1xb2B:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		3 / 3 LEU B 169
VAL B 220
ASP B 127
 None
 0.61A 4y8wC-1xb2B:
undetectable		 4y8wC-1xb2B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		3 / 3 THR B 129
HIS B 316
LEU B 269
 None
 0.84A 5axdC-1xb2B:
undetectable		 5axdC-1xb2B:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		4 / 6 PRO B 315
ILE B 307
GLY B 310
TYR B 312
 None
 1.11A 6gqiA-1xb2B:
undetectable		 6gqiA-1xb2B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL
(Bos
taurus) 		5 / 12 VAL B 151
VAL B 154
PHE B 147
ASN B 135
ILE B 203
 None
 1.37A 6mxtA-1xb2B:
undetectable		 6mxtA-1xb2B:
20.25