SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 ASP A  58
ASP A  97
GLY A  99
THR A 163
 TTP  A1195 (-3.2A)
MG  A1194 ( 4.3A)
None
TTP  A1195 ( 3.8A)
 0.82A 1m4iA-1xbtA:
undetectable		 1m4iA-1xbtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 12 LEU A 137
ALA A 123
ILE A 105
ILE A  96
ILE A 136
 None
 0.88A 2hs1B-1xbtA:
undetectable		 2hs1B-1xbtA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 10 ALA A  88
VAL A 119
ILE A 105
LEU A 139
ILE A  96
 None
 1.12A 3jw3A-1xbtA:
2.6		 3jw3A-1xbtA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 9 ALA A  88
VAL A 119
ILE A 105
LEU A 139
ILE A  96
 None
 1.11A 3jw3B-1xbtA:
2.2		 3jw3B-1xbtA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 ALA A  88
ASP A  97
ILE A  96
ILE A 105
 None
MG  A1194 ( 4.3A)
None
None
 0.84A 4kttB-1xbtA:
undetectable		 4kttB-1xbtA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 ALA A  88
ASP A  97
ILE A  96
ILE A 105
 None
MG  A1194 ( 4.3A)
None
None
 0.83A 4kttD-1xbtA:
undetectable		 4kttD-1xbtA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 ALA A  88
ASP A  97
ILE A  96
ILE A 105
 None
MG  A1194 ( 4.3A)
None
None
 0.87A 4ndnB-1xbtA:
undetectable		 4ndnB-1xbtA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 ALA A  88
ASP A  97
ILE A  96
ILE A 105
 None
MG  A1194 ( 4.3A)
None
None
 0.86A 4ndnD-1xbtA:
undetectable		 4ndnD-1xbtA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		5 / 12 LEU A 137
ALA A 123
ILE A 105
ILE A  96
ILE A 136
 None
 0.90A 4q1yB-1xbtA:
undetectable		 4q1yB-1xbtA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 ARG A 130
GLY A  26
PRO A  27
ASP A 125
 None
 1.07A 5kf8A-1xbtA:
undetectable		 5kf8A-1xbtA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 ARG A 130
GLY A  26
PRO A  27
ASP A 125
 None
 1.04A 5kgpA-1xbtA:
undetectable		 5kgpA-1xbtA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 ARG A 130
GLY A  26
PRO A  27
ASP A 125
 None
 1.04A 5kgpB-1xbtA:
undetectable		 5kgpB-1xbtA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 7 ALA A  88
ASP A  97
ILE A  96
ILE A 105
 None
MG  A1194 ( 4.3A)
None
None
 0.90A 6fbnA-1xbtA:
undetectable		 6fbnA-1xbtA:
20.65