SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		5 / 11 GLY A  54
GLY A   3
ILE A  96
LEU A  50
LEU A  87
 None
 1.13A 1jg3B-1xc3A:
undetectable		 1jg3B-1xc3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 8 ALA A 108
LEU A 109
GLY A 279
GLY A  56
 None
 0.83A 1rukH-1xc3A:
undetectable
1rukL-1xc3A:
undetectable		 1rukH-1xc3A:
20.57
1rukL-1xc3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 7 PHE A  86
VAL A  41
VAL A  98
ILE A  55
 None
 0.94A 1t87B-1xc3A:
undetectable		 1t87B-1xc3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 6 ARG A  26
ILE A 277
GLY A 276
ALA A 107
 None
 0.91A 1wmqA-1xc3A:
undetectable		 1wmqA-1xc3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 6 ARG A  26
ILE A 277
GLY A 276
ALA A 107
 None
 0.90A 1wmqB-1xc3A:
undetectable		 1wmqB-1xc3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 6 ARG A  26
ILE A 277
GLY A 276
ALA A 107
 None
 0.88A 1wpuA-1xc3A:
undetectable		 1wpuA-1xc3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 6 ARG A  26
ILE A 277
GLY A 276
ALA A 107
 None
 0.89A 1wpuB-1xc3A:
undetectable		 1wpuB-1xc3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 6 ARG A  26
ILE A 277
GLY A 276
ALA A 107
 None
 0.87A 1wrqA-1xc3A:
undetectable		 1wrqA-1xc3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 6 ARG A  26
ILE A 277
GLY A 276
ALA A 107
 None
 0.90A 1wrqB-1xc3A:
undetectable		 1wrqB-1xc3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		5 / 12 ALA A 106
VAL A  61
SER A 101
ASN A 105
GLY A 276
 None
 1.40A 2dcfA-1xc3A:
undetectable		 2dcfA-1xc3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 5 VAL A 104
THR A 102
VAL A  61
GLY A  59
 GOL  A 305 ( 4.6A)
GOL  A 305 ( 4.1A)
None
GOL  A 305 (-3.2A)
 1.14A 2p2fA-1xc3A:
2.4		 2p2fA-1xc3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 4 VAL A 104
THR A 102
VAL A  61
GLY A  59
 GOL  A 305 ( 4.6A)
GOL  A 305 ( 4.1A)
None
GOL  A 305 (-3.2A)
 1.18A 2p2fB-1xc3A:
undetectable		 2p2fB-1xc3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 8 PHE A  86
VAL A  41
VAL A  98
ILE A  55
 None
 0.92A 2qbmA-1xc3A:
undetectable		 2qbmA-1xc3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		3 / 3 PRO A 269
GLY A 228
TYR A 125
 None
 0.67A 2vouA-1xc3A:
undetectable		 2vouA-1xc3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		3 / 3 PRO A 269
GLY A 228
TYR A 125
 None
 0.66A 2vouB-1xc3A:
undetectable		 2vouB-1xc3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		3 / 3 PRO A 269
GLY A 228
TYR A 125
 None
 0.67A 2vouC-1xc3A:
undetectable		 2vouC-1xc3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		5 / 12 ALA A 106
VAL A  61
SER A 101
ASN A 105
GLY A 276
 None
 1.37A 3a65A-1xc3A:
undetectable		 3a65A-1xc3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		5 / 12 GLY A  71
GLY A  54
GLY A  56
THR A 280
ILE A  53
 None
 1.01A 3gczA-1xc3A:
undetectable		 3gczA-1xc3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		6 / 12 TYR A  44
ILE A  55
GLY A  54
GLY A   4
ALA A  15
PHE A 100
 None
 1.35A 3jayA-1xc3A:
undetectable		 3jayA-1xc3A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		5 / 12 GLY A  17
GLY A  54
GLY A   4
SER A 101
ALA A 284
 None
 1.05A 3kkzB-1xc3A:
undetectable		 3kkzB-1xc3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		5 / 12 ILE A 137
VAL A 138
GLY A 135
LEU A 143
ILE A 154
 None
 1.05A 3mb5A-1xc3A:
undetectable		 3mb5A-1xc3A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 7 PHE A  45
VAL A  90
GLY A  54
THR A 280
 None
 1.00A 4ejjB-1xc3A:
undetectable		 4ejjB-1xc3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 8 PHE A  86
VAL A  41
VAL A  98
ILE A  55
 None
 0.92A 4l4cB-1xc3A:
undetectable		 4l4cB-1xc3A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_G_MTXG301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		5 / 9 GLY A  21
GLY A 279
LEU A 281
HIS A 285
GLN A 286
 None
 1.22A 4l8wG-1xc3A:
undetectable		 4l8wG-1xc3A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		5 / 9 GLY A  21
GLY A 279
LEU A 281
HIS A 285
GLN A 286
 None
 1.14A 4l8wI-1xc3A:
0.7		 4l8wI-1xc3A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 5 PHE A 175
ILE A 128
GLY A 152
ILE A 209
 None
 0.82A 5dzkB-1xc3A:
undetectable
5dzkI-1xc3A:
undetectable
5dzkW-1xc3A:
undetectable		 5dzkB-1xc3A:
21.00
5dzkI-1xc3A:
20.79
5dzkW-1xc3A:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 5 PHE A 175
ILE A 128
GLY A 152
ILE A 209
 None
 0.85A 5dzkd-1xc3A:
undetectable
5dzkk-1xc3A:
undetectable
5dzky-1xc3A:
undetectable		 5dzkd-1xc3A:
21.00
5dzkk-1xc3A:
20.79
5dzky-1xc3A:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		4 / 5 TYR A  70
GLY A  71
THR A  72
LEU A 142
 None
 0.78A 5jlcA-1xc3A:
undetectable		 5jlcA-1xc3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		5 / 12 GLY A  21
LEU A 113
VAL A 282
LEU A 281
ALA A  15
 None
 0.89A 5kpcA-1xc3A:
undetectable		 5kpcA-1xc3A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1xc3 PUTATIVE
FRUCTOKINASE
(Bacillus
subtilis) 		5 / 12 LEU A 142
ILE A 137
ALA A 117
ALA A 275
GLY A  21
 None
 1.07A 5veuB-1xc3A:
undetectable		 5veuB-1xc3A:
19.67