SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xcf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 12 GLY A  44
ALA A  45
ILE A  37
PRO A  93
THR A  94
 None
 0.93A 1c6zA-1xcfA:
undetectable		 1c6zA-1xcfA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 12 GLY A  44
ILE A  37
PRO A  93
THR A  94
ILE A  95
 None
 0.94A 1c6zA-1xcfA:
undetectable		 1c6zA-1xcfA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 12 GLY A  44
ALA A  45
ILE A  37
PRO A  93
THR A  94
 None
 0.85A 1c6zB-1xcfA:
undetectable		 1c6zB-1xcfA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		4 / 8 SER A   6
PHE A   8
ALA A  18
LEU A 209
 None
 0.98A 2bxkA-1xcfA:
undetectable		 2bxkA-1xcfA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		4 / 8 SER A   6
PHE A   8
ALA A  18
LEU A 209
 None
 0.92A 2bxmA-1xcfA:
undetectable		 2bxmA-1xcfA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 12 GLU A  49
TYR A   4
LEU A   7
PHE A   8
LEU A  11
 None
 1.39A 2mjiA-1xcfA:
0.0		 2mjiA-1xcfA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		4 / 6 ARG A 140
PHE A 139
ILE A 111
PHE A 107
 None
 0.96A 2qeiA-1xcfA:
undetectable		 2qeiA-1xcfA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 12 LEU A  25
ILE A  37
LEU A  34
ALA A  86
LEU A  85
 None
 1.05A 4m11A-1xcfA:
undetectable		 4m11A-1xcfA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 12 GLY A  44
ILE A  37
PRO A  93
THR A  94
ILE A  95
 None
 1.01A 4njvD-1xcfA:
undetectable		 4njvD-1xcfA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 12 LEU A  48
ILE A  95
GLY A  44
ALA A  43
ILE A  36
 None
 0.94A 4nkxC-1xcfA:
undetectable		 4nkxC-1xcfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 12 LEU A  48
ILE A  95
GLY A  44
ALA A  43
ILE A  36
 None
 0.93A 4nkxD-1xcfA:
undetectable		 4nkxD-1xcfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		4 / 6 PHE A  19
GLY A  44
ILE A  37
LEU A   7
 None
 0.78A 4o8fB-1xcfA:
undetectable		 4o8fB-1xcfA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 10 ASP A 124
LEU A   7
ILE A 232
LEU A 209
PHE A 173
 None
 1.08A 4odoA-1xcfA:
undetectable		 4odoA-1xcfA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		6 / 11 TYR A   4
ASP A 124
LEU A   7
ILE A 232
LEU A 209
PHE A 173
 None
 1.34A 4odrA-1xcfA:
undetectable
4odrB-1xcfA:
undetectable		 4odrA-1xcfA:
18.89
4odrB-1xcfA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		4 / 8 LEU A 209
VAL A 197
LEU A 200
GLY A 170
 None
 0.88A 4r3aA-1xcfA:
undetectable		 4r3aA-1xcfA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		4 / 8 ASP A 161
TYR A 203
ASP A 160
ILE A 166
 None
 1.03A 4xjeA-1xcfA:
undetectable		 4xjeA-1xcfA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		5 / 8 ILE A 224
VAL A 220
VAL A  23
ILE A  37
ILE A  95
 None
 1.33A 5hi2A-1xcfA:
undetectable		 5hi2A-1xcfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Escherichia
coli) 		4 / 6 ARG A 140
ARG A 171
ALA A 143
PHE A 152
 None
 1.04A 5odqA-1xcfA:
undetectable		 5odqA-1xcfA:
19.05