SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xcj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		3 / 3 ASP A 134
ILE A 228
VAL A 232
 NMG  A 237 ( 3.0A)
None
None
 0.71A 2avvD-1xcjA:
undetectable		 2avvD-1xcjA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		3 / 3 GLY A  67
GLU A  89
ASP A 134
 SAH  A 236 (-3.4A)
SAH  A 236 (-2.9A)
NMG  A 237 ( 3.0A)
 0.36A 2b25B-1xcjA:
12.5		 2b25B-1xcjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 6 PHE A 156
PHE A 201
GLY A 162
GLY A 163
 None
 0.93A 2qr2A-1xcjA:
undetectable
2qr2B-1xcjA:
undetectable		 2qr2A-1xcjA:
21.77
2qr2B-1xcjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 5 GLY A 162
GLY A 163
PHE A 156
PHE A 201
 None
 0.98A 2qr2A-1xcjA:
undetectable
2qr2B-1xcjA:
undetectable		 2qr2A-1xcjA:
21.77
2qr2B-1xcjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 6 GLY A  67
ILE A  88
GLU A  89
ASP A 134
 SAH  A 236 (-3.4A)
None
SAH  A 236 (-2.9A)
NMG  A 237 ( 3.0A)
 0.34A 3a7eA-1xcjA:
13.5		 3a7eA-1xcjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 7 LEU A 196
ALA A 155
GLY A 163
ILE A 164
 None
 0.82A 3spkB-1xcjA:
undetectable		 3spkB-1xcjA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		3 / 3 TYR A 136
LEU A 112
LYS A 113
 None
 0.58A 3sueD-1xcjA:
undetectable		 3sueD-1xcjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 5 LEU A  52
ALA A  54
MET A 211
THR A 229
 None
 1.36A 3vasB-1xcjA:
4.6		 3vasB-1xcjA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 6 GLY A  69
GLU A  89
ASP A 134
GLU A 117
 SAH  A 236 (-3.3A)
SAH  A 236 (-2.9A)
NMG  A 237 ( 3.0A)
SAH  A 236 (-3.2A)
 0.69A 3vywC-1xcjA:
12.5		 3vywC-1xcjA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		3 / 3 ASN A 100
LEU A  33
PHE A  95
 None
 0.79A 4dajB-1xcjA:
undetectable		 4dajB-1xcjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 8 PRO A 230
LEU A  52
TYR A 167
TRP A 173
 None
 0.73A 4pwdA-1xcjA:
undetectable		 4pwdA-1xcjA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 8 PRO A 230
TYR A 167
TRP A 173
LEU A 170
 None
None
None
NMG  A 237 (-3.9A)
 0.93A 4pwdA-1xcjA:
undetectable		 4pwdA-1xcjA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		5 / 9 LEU A  52
LEU A 159
ARG A  59
LEU A 132
ILE A 131
 None
 1.22A 4ubsA-1xcjA:
undetectable		 4ubsA-1xcjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 6 GLU A  45
ILE A  87
HIS A  85
PRO A 230
 NMG  A 237 (-3.0A)
None
None
None
 1.07A 4xi3C-1xcjA:
undetectable		 4xi3C-1xcjA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 7 GLY A  67
GLY A  69
GLU A  89
ASP A 134
 SAH  A 236 (-3.4A)
SAH  A 236 (-3.3A)
SAH  A 236 (-2.9A)
NMG  A 237 ( 3.0A)
 0.53A 5ergB-1xcjA:
13.0		 5ergB-1xcjA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 5 TYR A 221
TRP A 143
PRO A 137
LEU A  33
 NMG  A 237 ( 4.7A)
None
None
None
 1.49A 5eshA-1xcjA:
undetectable		 5eshA-1xcjA:
17.43