SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		5 / 11 VAL A 311
LEU A 314
ALA A 315
ALA A 319
LEU A 121
 None
 0.96A 1jinA-1xcoA:
undetectable		 1jinA-1xcoA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		3 / 3 THR A 142
LEU A 295
LEU A 121
 None
 0.53A 1mz9C-1xcoA:
undetectable		 1mz9C-1xcoA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 PHE A 285
SER A 185
PHE A 243
ILE A 181
 None
 1.21A 2v0mD-1xcoA:
undetectable		 2v0mD-1xcoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 LEU A 137
LEU A 295
VAL A 299
ILE A 169
THR A 110
 None
 1.10A 3fl9B-1xcoA:
undetectable		 3fl9B-1xcoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLU A  52
ASN A  51
VAL A  67
GLY A  48
ILE A  53
 None
 1.14A 3k13C-1xcoA:
undetectable		 3k13C-1xcoA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		4 / 4 GLY A 235
GLU A 236
ASP A 219
ASP A 234
 None
 1.25A 3mb5A-1xcoA:
3.4		 3mb5A-1xcoA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 VAL A  20
TYR A 114
GLY A 109
LEU A 117
TYR A  75
 None
 1.30A 3mecA-1xcoA:
undetectable		 3mecA-1xcoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		4 / 8 VAL A  20
GLY A 120
ILE A 140
GLY A 109
 None
 0.77A 3n9jB-1xcoA:
undetectable		 3n9jB-1xcoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		3 / 3 ARG A  89
LYS A  90
LYS A  92
 UVW  A 402 (-2.7A)
None
UVW  A 402 (-2.6A)
 1.14A 4k50E-1xcoA:
undetectable		 4k50E-1xcoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		3 / 3 ARG A  89
LYS A  90
LYS A  92
 UVW  A 402 (-2.7A)
None
UVW  A 402 (-2.6A)
 1.14A 4k50I-1xcoA:
undetectable		 4k50I-1xcoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		4 / 6 LEU A 233
LEU A 201
VAL A 265
PHE A 237
 None
 1.18A 4uswA-1xcoA:
undetectable		 4uswA-1xcoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		4 / 7 LEU A 137
THR A 132
THR A 129
THR A 149
 None
None
UVW  A 418 (-4.1A)
None
 0.92A 4z90A-1xcoA:
undetectable
4z90B-1xcoA:
undetectable
4z90C-1xcoA:
undetectable
4z90D-1xcoA:
undetectable
4z90E-1xcoA:
undetectable		 4z90A-1xcoA:
21.20
4z90B-1xcoA:
21.20
4z90C-1xcoA:
21.20
4z90D-1xcoA:
21.20
4z90E-1xcoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		4 / 7 THR A 129
THR A 149
LEU A 137
THR A 132
 UVW  A 418 (-4.1A)
None
None
None
 0.89A 4z91F-1xcoA:
undetectable
4z91G-1xcoA:
undetectable
4z91H-1xcoA:
undetectable
4z91I-1xcoA:
undetectable
4z91J-1xcoA:
undetectable		 4z91F-1xcoA:
21.20
4z91G-1xcoA:
21.20
4z91H-1xcoA:
21.20
4z91I-1xcoA:
21.20
4z91J-1xcoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		5 / 10 LEU A  36
ALA A  32
THR A 318
GLY A 124
LEU A 302
 None
 1.18A 5m5cE-1xcoA:
undetectable		 5m5cE-1xcoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLN A   9
GLU A 309
LEU A 316
ILE A 317
ASP A 310
 None
 1.08A 5vlmG-1xcoA:
undetectable		 5vlmG-1xcoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLU A  52
ASN A  51
VAL A  67
GLY A  48
ILE A  53
 None
 1.12A 5vooB-1xcoA:
undetectable		 5vooB-1xcoA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1xco PHOSPHATE
ACETYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLU A  52
ASN A  51
VAL A  67
GLY A  48
ILE A  53
 None
 1.13A 5vooD-1xcoA:
3.3		 5vooD-1xcoA:
24.38