SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xcr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 12 GLU A 233
VAL A 234
HIS A 239
VAL A 133
ILE A 218
 None
 0.98A 1c9hA-1xcrA:
undetectable		 1c9hA-1xcrA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 6 VAL A 173
GLY A 292
ALA A 175
LEU A  24
 None
 0.75A 1e7bB-1xcrA:
undetectable		 1e7bB-1xcrA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 8 LEU A 192
GLY A  23
LEU A  16
TYR A 196
 None
 0.82A 1jlbA-1xcrA:
undetectable		 1jlbA-1xcrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 5 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.96A 1os2A-1xcrA:
undetectable		 1os2A-1xcrA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.94A 1os2D-1xcrA:
undetectable		 1os2D-1xcrA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 10 ALA A 155
HIS A 268
GLU A 110
HIS A 278
HIS A 266
 None
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 1.19A 1r55A-1xcrA:
undetectable		 1r55A-1xcrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 10 HIS A 268
GLU A 110
HIS A 278
HIS A 266
ALA A 158
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
None
 0.99A 1r55A-1xcrA:
undetectable		 1r55A-1xcrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 8 LEU A 192
GLY A  23
LEU A  16
TYR A 196
 None
 0.82A 1s1xA-1xcrA:
undetectable		 1s1xA-1xcrA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.99A 1uttA-1xcrA:
undetectable		 1uttA-1xcrA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.97A 1utzA-1xcrA:
undetectable		 1utzA-1xcrA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.94A 1utzB-1xcrA:
undetectable		 1utzB-1xcrA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 12 ILE A 171
VAL A  35
PHE A 253
MET A 203
LEU A  24
 None
 1.28A 1wsvA-1xcrA:
undetectable		 1wsvA-1xcrA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 6 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.97A 1y93A-1xcrA:
undetectable		 1y93A-1xcrA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.95A 2hu6A-1xcrA:
undetectable		 2hu6A-1xcrA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 6 LEU A  68
HIS A 268
GLU A 110
HIS A 278
HIS A 266
 None
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 1.15A 2ow9A-1xcrA:
undetectable		 2ow9A-1xcrA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 1.01A 2ow9B-1xcrA:
undetectable		 2ow9B-1xcrA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.96A 2ozrC-1xcrA:
undetectable		 2ozrC-1xcrA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.98A 2ozrD-1xcrA:
undetectable		 2ozrD-1xcrA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.99A 2ozrE-1xcrA:
undetectable		 2ozrE-1xcrA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 12 GLY A  98
LEU A 250
VAL A 248
ALA A 158
GLY A 127
 ACY  A2001 (-3.2A)
None
None
None
None
 1.08A 2vmyB-1xcrA:
undetectable		 2vmyB-1xcrA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 12 GLY A  98
LEU A 250
VAL A 248
ALA A 158
GLY A 127
 ACY  A2001 (-3.2A)
None
None
None
None
 1.03A 2vmyA-1xcrA:
undetectable		 2vmyA-1xcrA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 5 ILE A  59
THR A 267
PHE A 207
PHE A 294
 None
 1.35A 3em0A-1xcrA:
undetectable		 3em0A-1xcrA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 5 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.98A 3kecA-1xcrA:
undetectable		 3kecA-1xcrA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 5 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.95A 3likA-1xcrA:
undetectable		 3likA-1xcrA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.95A 3lilA-1xcrA:
undetectable		 3lilA-1xcrA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 5 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.93A 3ljgA-1xcrA:
undetectable		 3ljgA-1xcrA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 5 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.95A 3lkaA-1xcrA:
undetectable		 3lkaA-1xcrA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 5 LEU A 262
PHE A 260
ARG A 302
ALA A   4
 None
 1.47A 3vm4A-1xcrA:
undetectable		 3vm4A-1xcrA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 6 LEU A  68
HIS A 268
GLU A 110
HIS A 278
HIS A 266
 None
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 1.19A 4a7bA-1xcrA:
undetectable		 4a7bA-1xcrA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 5 LEU A  68
HIS A 268
GLU A 110
HIS A 278
 None
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
 1.08A 4a7bB-1xcrA:
undetectable		 4a7bB-1xcrA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 5 LEU A  68
HIS A 278
GLU A 110
HIS A 217
 None
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
None
 1.09A 4a7bB-1xcrA:
undetectable		 4a7bB-1xcrA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 5 LEU A 157
HIS A 278
GLU A 110
HIS A 217
 ACY  A2001 (-4.7A)
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
None
 1.29A 4a7bB-1xcrA:
undetectable		 4a7bB-1xcrA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 12 CYH A 140
LEU A 142
THR A 267
ILE A 218
ALA A 131
 None
 0.95A 4o2bD-1xcrA:
undetectable		 4o2bD-1xcrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 12 GLU A 233
VAL A 234
HIS A 239
VAL A 133
ILE A 218
 None
 0.94A 5hkgA-1xcrA:
undetectable		 5hkgA-1xcrA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 12 ARG A 302
VAL A 254
LEU A 264
GLY A 259
LEU A 300
 None
 1.01A 5ikrB-1xcrA:
undetectable		 5ikrB-1xcrA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.95A 5n5jA-1xcrA:
undetectable		 5n5jA-1xcrA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 5 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.95A 5n5kA-1xcrA:
undetectable		 5n5kA-1xcrA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 12 CYH A 140
LEU A 142
THR A 267
ILE A 218
ALA A 131
 None
 0.94A 5nm5B-1xcrA:
undetectable		 5nm5B-1xcrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 8 PRO A  11
TYR A 196
VAL A  19
GLY A  18
 None
 0.95A 5nzyA-1xcrA:
undetectable		 5nzyA-1xcrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 12 CYH A 140
LEU A 142
THR A 267
ILE A 218
ALA A 131
 None
 0.95A 5xiwB-1xcrA:
undetectable		 5xiwB-1xcrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 12 CYH A 140
LEU A 142
THR A 267
ILE A 218
ALA A 131
 None
 1.03A 5xiwD-1xcrA:
undetectable		 5xiwD-1xcrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		4 / 4 PRO A 251
MET A  20
GLY A  23
VAL A 173
 None
 1.43A 6ak3A-1xcrA:
undetectable		 6ak3A-1xcrA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		3 / 3 LYS A 169
VAL A  35
ASP A  37
 None
 0.45A 6fgdA-1xcrA:
undetectable		 6fgdA-1xcrA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens) 		5 / 10 THR A 267
GLY A 205
GLY A 204
VAL A 185
PHE A  48
 None
 1.48A 6nqaK-1xcrA:
undetectable		 6nqaK-1xcrA:
19.67