SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xdk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		4 / 4 GLY B 294
LEU B 391
GLY B 296
ARG B 387
 9CR  B 600 (-4.7A)
None
None
None
 1.27A 1j7kA-1xdkB:
undetectable		 1j7kA-1xdkB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		3 / 3 ASP B 316
LYS B 186
ARG B 238
 None
 1.02A 1ra8A-1xdkB:
undetectable		 1ra8A-1xdkB:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		5 / 12 PHE B 235
LEU B 239
ILE B 325
ALA B 324
THR B 319
 None
 1.11A 2g78A-1xdkB:
undetectable		 2g78A-1xdkB:
18.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		10 / 12 PHE B 221
CYH B 228
LEU B 262
ARG B 265
ILE B 266
ARG B 269
PHE B 279
SER B 280
GLY B 384
LEU B 391
 9CR  B 600 ( 4.7A)
9CR  B 600 (-3.4A)
9CR  B 600 (-3.9A)
None
9CR  B 600 ( 3.8A)
9CR  B 600 (-3.8A)
9CR  B 600 (-4.5A)
9CR  B 600 (-3.0A)
9CR  B 600 ( 4.6A)
None
 0.55A 2lbdA-1xdkB:
37.7		 2lbdA-1xdkB:
79.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		6 / 12 PHE B 221
LYS B 227
LEU B 262
PHE B 279
GLY B 384
LEU B 391
 9CR  B 600 ( 4.7A)
None
9CR  B 600 (-3.9A)
9CR  B 600 (-4.5A)
9CR  B 600 ( 4.6A)
None
 1.07A 2lbdA-1xdkB:
37.7		 2lbdA-1xdkB:
79.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		5 / 11 ILE B 266
ARG B 269
PHE B 279
SER B 280
LEU B 213
 9CR  B 600 ( 3.8A)
9CR  B 600 (-3.8A)
9CR  B 600 (-4.5A)
9CR  B 600 (-3.0A)
None
 1.35A 3a9eB-1xdkB:
37.9		 3a9eB-1xdkB:
77.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		10 / 11 PHE B 221
CYH B 228
LEU B 262
ILE B 266
ARG B 269
PHE B 279
SER B 280
PHE B 295
VAL B 388
LEU B 391
 9CR  B 600 ( 4.7A)
9CR  B 600 (-3.4A)
9CR  B 600 (-3.9A)
9CR  B 600 ( 3.8A)
9CR  B 600 (-3.8A)
9CR  B 600 (-4.5A)
9CR  B 600 (-3.0A)
9CR  B 600 (-3.9A)
9CR  B 600 ( 4.6A)
None
 0.42A 3a9eB-1xdkB:
37.9		 3a9eB-1xdkB:
77.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		10 / 12 PHE B 221
ALA B 225
LEU B 259
LEU B 262
ILE B 266
ARG B 269
SER B 280
PHE B 295
GLY B 384
ILE B 403
 9CR  B 600 ( 4.7A)
9CR  B 600 (-3.8A)
None
9CR  B 600 (-3.9A)
9CR  B 600 ( 3.8A)
9CR  B 600 (-3.8A)
9CR  B 600 (-3.0A)
9CR  B 600 (-3.9A)
9CR  B 600 ( 4.6A)
9CR  B 600 ( 4.4A)
 0.55A 3lbdA-1xdkB:
37.5		 3lbdA-1xdkB:
79.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		11 / 11 PHE B 221
CYH B 228
LEU B 259
LEU B 262
ILE B 263
ARG B 269
PHE B 279
SER B 280
LEU B 298
LEU B 391
ILE B 403
 9CR  B 600 ( 4.7A)
9CR  B 600 (-3.4A)
None
9CR  B 600 (-3.9A)
9CR  B 600 (-4.0A)
9CR  B 600 (-3.8A)
9CR  B 600 (-4.5A)
9CR  B 600 (-3.0A)
9CR  B 600 (-4.7A)
None
9CR  B 600 ( 4.4A)
 0.50A 4dm8A-1xdkB:
37.7		 4dm8A-1xdkB:
92.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		12 / 12 PHE B 192
PHE B 221
LEU B 224
ALA B 225
LEU B 259
LEU B 262
ILE B 263
ARG B 269
SER B 280
PHE B 295
GLY B 384
LEU B 391
 9CR  B 600 (-4.8A)
9CR  B 600 ( 4.7A)
9CR  B 600 ( 4.0A)
9CR  B 600 (-3.8A)
None
9CR  B 600 (-3.9A)
9CR  B 600 (-4.0A)
9CR  B 600 (-3.8A)
9CR  B 600 (-3.0A)
9CR  B 600 (-3.9A)
9CR  B 600 ( 4.6A)
None
 0.51A 4dm8B-1xdkB:
38.2		 4dm8B-1xdkB:
92.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		5 / 10 LEU B 348
HIS B 188
LEU B 321
ALA B 324
LEU B 239
 None
 1.27A 4p65A-1xdkB:
undetectable
4p65B-1xdkB:
undetectable
4p65F-1xdkB:
undetectable
4p65H-1xdkB:
undetectable		 4p65A-1xdkB:
7.50
4p65B-1xdkB:
14.16
4p65F-1xdkB:
14.16
4p65H-1xdkB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		4 / 8 PHE B 305
THR B 319
ASP B 315
ASP B 316
 None
 1.38A 4qb9D-1xdkB:
undetectable		 4qb9D-1xdkB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		3 / 3 MET B 314
GLU B 318
LEU B 322
 None
 0.50A 4v2oB-1xdkB:
0.0		 4v2oB-1xdkB:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		4 / 7 GLU B 318
LEU B 322
LEU B 264
LEU B 377
 None
 0.80A 4wg0B-1xdkB:
undetectable
4wg0C-1xdkB:
undetectable		 4wg0B-1xdkB:
5.60
4wg0C-1xdkB:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		4 / 7 LEU B 264
LEU B 377
GLU B 318
LEU B 322
 None
 0.82A 4wg0L-1xdkB:
undetectable
4wg0M-1xdkB:
undetectable		 4wg0L-1xdkB:
5.60
4wg0M-1xdkB:
5.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		11 / 12 TRP B 218
PHE B 221
ALA B 225
LEU B 262
ILE B 266
ARG B 269
SER B 280
PHE B 295
GLY B 384
LEU B 391
ILE B 403
 None
9CR  B 600 ( 4.7A)
9CR  B 600 (-3.8A)
9CR  B 600 (-3.9A)
9CR  B 600 ( 3.8A)
9CR  B 600 (-3.8A)
9CR  B 600 (-3.0A)
9CR  B 600 (-3.9A)
9CR  B 600 ( 4.6A)
None
9CR  B 600 ( 4.4A)
 0.49A 5m24A-1xdkB:
37.5		 5m24A-1xdkB:
79.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		12 / 12 PHE B 221
ALA B 225
CYH B 228
LEU B 259
LEU B 262
ILE B 263
ILE B 266
PHE B 279
SER B 280
PHE B 295
LEU B 298
VAL B 388
 9CR  B 600 ( 4.7A)
9CR  B 600 (-3.8A)
9CR  B 600 (-3.4A)
None
9CR  B 600 (-3.9A)
9CR  B 600 (-4.0A)
9CR  B 600 ( 3.8A)
9CR  B 600 (-4.5A)
9CR  B 600 (-3.0A)
9CR  B 600 (-3.9A)
9CR  B 600 (-4.7A)
9CR  B 600 ( 4.6A)
 0.43A 5uanB-1xdkB:
38.3		 5uanB-1xdkB:
98.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		5 / 12 PHE B 221
CYH B 228
LEU B 407
PHE B 279
PHE B 295
 9CR  B 600 ( 4.7A)
9CR  B 600 (-3.4A)
None
9CR  B 600 (-4.5A)
9CR  B 600 (-3.9A)
 1.33A 5uanB-1xdkB:
38.3		 5uanB-1xdkB:
98.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1xdk RETINOIC ACID
RECEPTOR, BETA
(Mus
musculus) 		5 / 12 ALA B 187
ARG B 185
PHE B 235
GLY B 320
ILE B 325
 None
 1.11A 5ul4A-1xdkB:
undetectable		 5ul4A-1xdkB:
17.85