SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xdn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		5 / 11 TYR A  58
GLY A  94
PHE A 230
LEU A 240
ALA A 243
 ATP  A 501 (-4.7A)
None
None
None
ATP  A 501 ( 4.4A)
 1.31A 1e3vB-1xdnA:
0.0		 1e3vB-1xdnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		3 / 3 LEU A 266
PRO A 265
LEU A 269
 None
 0.51A 1hrkA-1xdnA:
undetectable		 1hrkA-1xdnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		4 / 4 LEU A 266
PRO A 267
LEU A 269
ARG A 244
 None
 1.24A 1hrkB-1xdnA:
undetectable		 1hrkB-1xdnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		3 / 3 ASP A 252
LEU A 255
HIS A 300
 None
 0.60A 1qknA-1xdnA:
undetectable		 1qknA-1xdnA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		4 / 4 LEU A 270
SER A 201
TYR A 200
LEU A 266
 None
 1.27A 1xz1A-1xdnA:
undetectable		 1xz1A-1xdnA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		4 / 4 LEU A 270
SER A 201
TYR A 200
LEU A 266
 None
 1.27A 1xz3A-1xdnA:
undetectable		 1xz3A-1xdnA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		4 / 4 LEU A 266
PRO A 267
LEU A 269
ARG A 244
 None
 1.32A 2hrcA-1xdnA:
undetectable		 2hrcA-1xdnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		4 / 4 LEU A 266
PRO A 267
LEU A 269
ARG A 244
 None
 1.23A 2hrcB-1xdnA:
undetectable		 2hrcB-1xdnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		4 / 4 LEU A 266
PRO A 267
LEU A 269
ARG A 244
 None
 1.30A 2pnjB-1xdnA:
undetectable		 2pnjB-1xdnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		3 / 3 LEU A 266
PRO A 265
LEU A 269
 None
 0.54A 2po5B-1xdnA:
undetectable		 2po5B-1xdnA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		3 / 3 LEU A 266
PRO A 265
LEU A 269
 None
 0.57A 2po7B-1xdnA:
undetectable		 2po7B-1xdnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		4 / 5 PHE A 262
PRO A 267
VAL A 290
PHE A 207
 None
 1.27A 2ygnA-1xdnA:
undetectable		 2ygnA-1xdnA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		7 / 12 ILE A  61
LYS A  87
ASN A  92
ARG A 111
PHE A 209
VAL A 286
LYS A 307
 ATP  A 501 (-4.2A)
ATP  A 501 (-2.9A)
ATP  A 501 (-3.8A)
ATP  A 501 (-2.8A)
ATP  A 501 (-3.6A)
ATP  A 501 (-4.4A)
ATP  A 501 (-2.7A)
 1.05A 3qwuA-1xdnA:
10.8		 3qwuA-1xdnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		8 / 12 TYR A  58
ILE A  61
LYS A  87
ASN A  92
GLU A 159
PHE A 209
VAL A 286
LYS A 307
 ATP  A 501 (-4.7A)
ATP  A 501 (-4.2A)
ATP  A 501 (-2.9A)
ATP  A 501 (-3.8A)
ATP  A 501 (-3.1A)
ATP  A 501 (-3.6A)
ATP  A 501 (-4.4A)
ATP  A 501 (-2.7A)
 0.63A 3qwuA-1xdnA:
10.8		 3qwuA-1xdnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		6 / 11 ILE A  61
LYS A  87
ASN A  92
ARG A 111
PHE A 209
VAL A 286
 ATP  A 501 (-4.2A)
ATP  A 501 (-2.9A)
ATP  A 501 (-3.8A)
ATP  A 501 (-2.8A)
ATP  A 501 (-3.6A)
ATP  A 501 (-4.4A)
 0.94A 3qwuB-1xdnA:
11.8		 3qwuB-1xdnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		7 / 11 TYR A  58
ILE A  61
LYS A  87
ASN A  92
GLU A 159
PHE A 209
VAL A 286
 ATP  A 501 (-4.7A)
ATP  A 501 (-4.2A)
ATP  A 501 (-2.9A)
ATP  A 501 (-3.8A)
ATP  A 501 (-3.1A)
ATP  A 501 (-3.6A)
ATP  A 501 (-4.4A)
 0.62A 3qwuB-1xdnA:
11.8		 3qwuB-1xdnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		4 / 7 ILE A 126
GLY A 123
PHE A  93
LEU A 160
 None
 0.80A 3v7pA-1xdnA:
undetectable		 3v7pA-1xdnA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		3 / 3 LEU A 266
PRO A 265
LEU A 269
 None
 0.46A 3w1wB-1xdnA:
undetectable		 3w1wB-1xdnA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 1xdn RNA EDITING LIGASE
MP52
(Trypanosoma
brucei) 		5 / 12 PHE A 131
LEU A 160
VAL A 190
THR A 132
GLU A 203
 None
 1.47A 5v1tA-1xdnA:
undetectable		 5v1tA-1xdnA:
21.16