SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xdv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		5 / 12 LEU A 872
SER A 876
VAL A 927
LEU A 795
HIS A 827
 None
 1.34A 1db1A-1xdvA:
1.1		 1db1A-1xdvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		5 / 12 LEU A 872
SER A 876
VAL A 927
LEU A 795
HIS A 827
 None
 1.42A 1rk3A-1xdvA:
1.2		 1rk3A-1xdvA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 8 LEU A 324
ILE A 245
PHE A 246
PHE A 237
 None
 0.98A 2weyB-1xdvA:
2.3		 2weyB-1xdvA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 8 TYR A 353
LEU A 380
ALA A 299
ILE A 252
 None
 0.82A 3jusB-1xdvA:
undetectable		 3jusB-1xdvA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 6 PHE A 634
TYR A 631
CYH A 635
PHE A 627
 None
 0.91A 3ltwA-1xdvA:
2.1		 3ltwA-1xdvA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 6 ARG A 722
VAL A 685
PHE A 648
GLU A 646
 None
 1.39A 3ufrA-1xdvA:
undetectable
3ufrB-1xdvA:
undetectable		 3ufrA-1xdvA:
18.78
3ufrB-1xdvA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 5 LEU A 934
GLY A 931
MET A 824
ASN A 869
 None
 1.11A 3uq6B-1xdvA:
undetectable		 3uq6B-1xdvA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		5 / 12 LEU A 872
SER A 876
VAL A 927
LEU A 795
HIS A 827
 None
 1.41A 3vt3A-1xdvA:
0.2		 3vt3A-1xdvA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 4 PRO A 340
LEU A 339
ILE A 222
ARG A 227
 None
 1.40A 3w1wA-1xdvA:
undetectable		 3w1wA-1xdvA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 6 GLU A 361
LYS A 370
LYS A 363
GLU A 365
 None
 1.43A 4a7tF-1xdvA:
undetectable		 4a7tF-1xdvA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 5 ILE A 252
ILE A 212
TYR A 215
GLU A 211
 None
 1.02A 4a99D-1xdvA:
undetectable		 4a99D-1xdvA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 8 SER A 256
LEU A 259
PHE A 208
TYR A 215
 None
 1.17A 4j7uD-1xdvA:
undetectable		 4j7uD-1xdvA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		3 / 3 ASP A 241
ASN A 233
SER A 313
 None
 0.52A 4obwA-1xdvA:
undetectable		 4obwA-1xdvA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 5 GLN A 336
LEU A 315
SER A 316
ASP A 309
 None
 1.09A 4qtuD-1xdvA:
undetectable		 4qtuD-1xdvA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		5 / 12 ILE A 437
LYS A 498
GLN A 500
LEU A 541
LEU A 463
 None
 1.12A 4qztA-1xdvA:
undetectable		 4qztA-1xdvA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 8 GLU A 792
LEU A 919
LEU A 872
GLY A 931
 None
 0.83A 4r3aA-1xdvA:
undetectable		 4r3aA-1xdvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 6 PHE A 648
GLU A 646
ARG A 722
VAL A 685
 None
 1.37A 5ad9A-1xdvA:
0.0
5ad9B-1xdvA:
0.0		 5ad9A-1xdvA:
18.78
5ad9B-1xdvA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		3 / 3 PHE A 717
ILE A 644
ASP A 703
 None
 0.45A 5cswA-1xdvA:
undetectable		 5cswA-1xdvA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		3 / 3 PHE A 717
ILE A 644
ASP A 703
 None
 0.43A 5cswB-1xdvA:
undetectable		 5cswB-1xdvA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		5 / 9 LEU A 788
HIS A 827
ILE A 855
GLU A 857
VAL A 861
 None
 0.70A 5igzA-1xdvA:
2.9		 5igzA-1xdvA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		3 / 3 GLY A 438
CYH A 441
CYH A 440
 None
 0.92A 5inzB-1xdvA:
undetectable		 5inzB-1xdvA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		3 / 3 ARG A 304
ILE A 245
PHE A 311
 None
 0.76A 5kirA-1xdvA:
undetectable		 5kirA-1xdvA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		5 / 10 LEU A 776
ILE A 784
PHE A 835
PRO A 781
VAL A 874
 None
 1.34A 5m0oA-1xdvA:
undetectable		 5m0oA-1xdvA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 7 HIS A 695
HIS A 700
LEU A 640
VAL A 624
 None
 1.01A 5m8rA-1xdvA:
undetectable		 5m8rA-1xdvA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 8 HIS A 695
HIS A 700
LEU A 640
VAL A 624
 None
 1.00A 5m8rD-1xdvA:
undetectable		 5m8rD-1xdvA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 5 PHE A 929
PHE A 930
LEU A 934
LEU A 919
 None
 1.35A 5veuH-1xdvA:
undetectable		 5veuH-1xdvA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 7 HIS A 780
PRO A 781
ILE A 782
SER A 853
 None
 0.86A 5vkqA-1xdvA:
0.0
5vkqD-1xdvA:
0.0		 5vkqA-1xdvA:
18.19
5vkqD-1xdvA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 7 PHE A 648
GLU A 646
ARG A 722
VAL A 685
 None
 1.39A 5vusA-1xdvA:
2.1
5vusB-1xdvA:
undetectable		 5vusA-1xdvA:
18.78
5vusB-1xdvA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		5 / 12 MET A 538
LEU A 541
ILE A 461
HIS A 460
ALA A 528
 None
 1.19A 6djzA-1xdvA:
undetectable		 6djzA-1xdvA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens) 		4 / 4 ASP A 775
ILE A 784
PRO A 781
LEU A 779
 None
 1.49A 6mkeB-1xdvA:
undetectable		 6mkeB-1xdvA:
6.10