SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xdw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE
(Acidaminococcus
fermentans) 		4 / 4 ILE A 201
MET A 224
VAL A 239
GLY A 150
 None
 1.35A 1e06B-1xdwA:
undetectable		 1e06B-1xdwA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE
(Acidaminococcus
fermentans) 		4 / 8 LEU A 109
THR A 203
VAL A 231
ALA A 234
 None
 0.93A 1fiqC-1xdwA:
1.4		 1fiqC-1xdwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE
(Acidaminococcus
fermentans) 		3 / 3 ASN A 146
ILE A 201
MET A 115
 None
 0.85A 2h42C-1xdwA:
undetectable		 2h42C-1xdwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE
(Acidaminococcus
fermentans) 		4 / 7 ILE A  64
ILE A  83
LEU A  51
ILE A  73
 None
 0.83A 2q83A-1xdwA:
undetectable		 2q83A-1xdwA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE
(Acidaminococcus
fermentans) 		4 / 6 TYR A  25
LEU A  74
ASN A 316
ASP A 325
 None
 1.48A 2w98A-1xdwA:
5.2
2w98B-1xdwA:
4.1		 2w98A-1xdwA:
23.24
2w98B-1xdwA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE
(Acidaminococcus
fermentans) 		4 / 8 SER A 313
HIS A  82
CYH A  55
ARG A  52
 None
 1.18A 3b9lA-1xdwA:
undetectable		 3b9lA-1xdwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE
(Acidaminococcus
fermentans) 		4 / 7 ASP A  63
ILE A  73
VAL A  49
TYR A   6
 None
 1.05A 3p6hA-1xdwA:
undetectable		 3p6hA-1xdwA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE
(Acidaminococcus
fermentans) 		3 / 3 VAL A 111
HIS A 166
VAL A 172
 None
 0.70A 5jmnC-1xdwA:
undetectable		 5jmnC-1xdwA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE
(Acidaminococcus
fermentans) 		4 / 5 GLU A 264
GLY A  53
ARG A 235
GLY A  79
 None
 1.01A 5kprA-1xdwA:
undetectable		 5kprA-1xdwA:
22.71