SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xdz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		3 / 3 THR A 190
LEU A 191
LEU A 162
 None
 0.59A 1mz9C-1xdzA:
undetectable		 1mz9C-1xdzA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		4 / 5 PHE A  55
LEU A 116
PHE A   6
SER A  18
 None
 1.17A 1wrkB-1xdzA:
0.0		 1wrkB-1xdzA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		3 / 3 VAL A  96
VAL A 144
ASP A  57
 None
 0.78A 2fumD-1xdzA:
undetectable		 2fumD-1xdzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		5 / 12 GLY A  79
ASP A 100
ALA A 128
GLU A 129
ARG A 147
 None
 0.64A 2gluA-1xdzA:
14.9		 2gluA-1xdzA:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 11 GLY A  77
GLY A  79
ASP A 100
ALA A 128
GLU A 129
ARG A 147
 None
 0.83A 3g88A-1xdzA:
31.6		 3g88A-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 11 GLY A  79
PHE A  82
ARG A 127
ALA A 128
GLU A 129
ARG A 147
 None
 0.83A 3g88A-1xdzA:
31.6		 3g88A-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 11 GLY A  79
PHE A  82
ASP A 100
ALA A 128
GLU A 129
ARG A 147
 None
 0.66A 3g88A-1xdzA:
31.6		 3g88A-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 11 GLY A  77
GLY A  79
ASP A 100
ALA A 128
GLU A 129
ARG A 147
 None
 0.83A 3g88B-1xdzA:
31.6		 3g88B-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 11 GLY A  79
PHE A  82
ARG A 127
ALA A 128
GLU A 129
ARG A 147
 None
 0.83A 3g88B-1xdzA:
31.6		 3g88B-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 11 GLY A  79
PHE A  82
ASP A 100
ALA A 128
GLU A 129
ARG A 147
 None
 0.66A 3g88B-1xdzA:
31.6		 3g88B-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 12 GLY A  77
GLY A  79
ASP A 100
ALA A 128
GLU A 129
ARG A 147
 None
 0.82A 3g89A-1xdzA:
31.5		 3g89A-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 12 GLY A  79
PHE A  82
ARG A 127
ALA A 128
GLU A 129
ARG A 147
 None
 0.93A 3g89A-1xdzA:
31.5		 3g89A-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 12 GLY A  79
PHE A  82
ASP A 100
ALA A 128
GLU A 129
ARG A 147
 None
 0.71A 3g89A-1xdzA:
31.5		 3g89A-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 11 GLY A  77
GLY A  79
ASP A 100
ALA A 128
GLU A 129
ARG A 147
 None
 0.83A 3g89B-1xdzA:
31.5		 3g89B-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		7 / 11 GLY A  79
PHE A  82
ASP A 100
ARG A 127
ALA A 128
GLU A 129
ARG A 147
 None
 0.81A 3g89B-1xdzA:
31.5		 3g89B-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 12 GLY A  77
GLY A  79
ASP A 100
ALA A 128
GLU A 129
ARG A 147
 None
 0.81A 3g8bA-1xdzA:
32.5		 3g8bA-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		7 / 12 GLY A  79
PHE A  82
ASP A 100
ARG A 127
ALA A 128
GLU A 129
ARG A 147
 None
 0.81A 3g8bA-1xdzA:
32.5		 3g8bA-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		6 / 12 GLY A  77
GLY A  79
ASP A 100
ALA A 128
GLU A 129
ARG A 147
 None
 0.81A 3g8bB-1xdzA:
32.5		 3g8bB-1xdzA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		7 / 12 GLY A  79
PHE A  82
ASP A 100
ARG A 127
ALA A 128
GLU A 129
ARG A 147
 None
 0.83A 3g8bB-1xdzA:
32.5		 3g8bB-1xdzA:
36.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		5 / 12 ILE A  98
GLY A  77
ALA A 148
ALA A 128
PHE A 123
 None
 1.06A 3jayA-1xdzA:
8.0		 3jayA-1xdzA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		3 / 3 LEU A 112
MET A  31
ASP A  57
 None
 0.76A 4j7xB-1xdzA:
4.7		 4j7xB-1xdzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		4 / 8 THR A 221
ILE A 218
LEU A 162
VAL A 170
 None
 0.99A 4r38B-1xdzA:
undetectable		 4r38B-1xdzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		4 / 5 TYR A  51
PRO A  86
LEU A  32
TYR A  28
 None
 1.36A 4w5qA-1xdzA:
undetectable		 4w5qA-1xdzA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		4 / 6 LEU A 152
ASN A 211
ILE A 198
MET A 213
 None
 0.94A 4ww7A-1xdzA:
0.4		 4ww7A-1xdzA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		4 / 6 TYR A  51
PRO A  86
LEU A  32
TYR A  28
 None
 1.38A 4z4cA-1xdzA:
undetectable		 4z4cA-1xdzA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		5 / 12 GLY A  77
GLY A  79
ASP A 100
ARG A 105
GLU A 129
 None
 1.09A 5bw4A-1xdzA:
11.7		 5bw4A-1xdzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		4 / 4 ASP A  75
GLY A  79
ASP A 100
ASP A 126
 None
 1.20A 5e72A-1xdzA:
14.4		 5e72A-1xdzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		5 / 9 ILE A  59
VAL A  70
LEU A  94
ILE A  73
LEU A  17
 None
 1.12A 5iepA-1xdzA:
undetectable		 5iepA-1xdzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 1xdz METHYLTRANSFERASE
GIDB
(Bacillus
subtilis) 		4 / 6 GLU A 129
GLY A 230
ARG A 127
ARG A 151
 None
 1.47A 5jcnB-1xdzA:
undetectable		 5jcnB-1xdzA:
21.27