SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xe4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 1xe4 FEMX
(Weissella
viridescens) 		5 / 10 LEU A 246
ILE A 244
TYR A 256
LEU A 192
VAL A  35
 None
 1.12A 1cqpA-1xe4A:
undetectable
1cqpB-1xe4A:
undetectable		 1cqpA-1xe4A:
19.69
1cqpB-1xe4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 8 ALA A  94
LEU A  98
LEU A 105
ALA A  71
 None
 0.79A 1e7cA-1xe4A:
undetectable		 1e7cA-1xe4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 6 ALA A 222
SER A 185
TRP A 253
TRP A  32
 None
 1.19A 1gahA-1xe4A:
undetectable		 1gahA-1xe4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 7 MET A  36
PHE A 195
MET A 219
ALA A 222
 None
 1.35A 1linA-1xe4A:
undetectable		 1linA-1xe4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xe4 FEMX
(Weissella
viridescens) 		5 / 12 LEU A 246
GLU A  15
GLY A  31
ALA A 222
ALA A 221
 None
 1.05A 2br4F-1xe4A:
undetectable		 2br4F-1xe4A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1xe4 FEMX
(Weissella
viridescens) 		5 / 12 GLY A  76
GLY A  24
GLU A 319
ILE A 320
ALA A  73
 None
 0.99A 2plwA-1xe4A:
undetectable		 2plwA-1xe4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 1xe4 FEMX
(Weissella
viridescens) 		5 / 10 ASP A 288
GLN A  25
LYS A  75
SER A  74
GLN A 143
 None
 0.93A 2qisA-1xe4A:
undetectable		 2qisA-1xe4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 7 PHE A 107
VAL A  91
VAL A  95
LEU A  98
 None
 0.69A 3hs6B-1xe4A:
undetectable		 3hs6B-1xe4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1xe4 FEMX
(Weissella
viridescens) 		3 / 3 SER A 294
ASP A 135
ASP A 298
 None
 0.69A 3iv6A-1xe4A:
undetectable		 3iv6A-1xe4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1xe4 FEMX
(Weissella
viridescens) 		3 / 3 SER A 294
ASP A 135
ASP A 298
 None
 0.69A 3iv6C-1xe4A:
undetectable		 3iv6C-1xe4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 1xe4 FEMX
(Weissella
viridescens) 		3 / 3 TYR A 126
ASP A  83
ASP A  88
 None
 0.82A 3r24A-1xe4A:
undetectable		 3r24A-1xe4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 4 LEU A 289
GLY A 290
MET A 275
PHE A 304
 None
 1.35A 3vaqB-1xe4A:
undetectable		 3vaqB-1xe4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 7 TRP A 278
VAL A 183
PHE A 231
ILE A 252
 None
 0.98A 3zjqB-1xe4A:
undetectable		 3zjqB-1xe4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 8 ASP A  83
ASP A  80
VAL A 111
LEU A 121
 None
 0.99A 4f8hA-1xe4A:
undetectable
4f8hB-1xe4A:
undetectable		 4f8hA-1xe4A:
21.27
4f8hB-1xe4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 8 ASP A  83
ASP A  80
VAL A 111
LEU A 121
 None
 0.97A 4f8hC-1xe4A:
undetectable
4f8hD-1xe4A:
undetectable		 4f8hC-1xe4A:
21.27
4f8hD-1xe4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 8 ASP A  83
ASP A  80
VAL A 111
LEU A 121
 None
 0.98A 4f8hD-1xe4A:
undetectable
4f8hE-1xe4A:
undetectable		 4f8hD-1xe4A:
21.27
4f8hE-1xe4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 8 VAL A 111
LEU A 121
ASP A  83
ASP A  80
 None
 0.98A 4f8hA-1xe4A:
undetectable
4f8hE-1xe4A:
undetectable		 4f8hA-1xe4A:
21.27
4f8hE-1xe4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 7 ILE A 244
LEU A 246
PHE A 223
GLY A  31
 None
 0.87A 4hajA-1xe4A:
undetectable		 4hajA-1xe4A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 1xe4 FEMX
(Weissella
viridescens) 		5 / 12 VAL A  78
LEU A  46
LEU A   3
LEU A   5
ALA A  33
 None
 1.14A 4rtbA-1xe4A:
undetectable		 4rtbA-1xe4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1xe4 FEMX
(Weissella
viridescens) 		3 / 3 PHE A 308
ILE A 276
ASP A 151
 None
 0.76A 5cswA-1xe4A:
undetectable		 5cswA-1xe4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1xe4 FEMX
(Weissella
viridescens) 		3 / 3 PHE A 308
ILE A 276
ASP A 151
 None
 0.72A 5cswB-1xe4A:
undetectable		 5cswB-1xe4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 5 TYR A  45
LYS A   1
LEU A  90
GLU A  93
 None
 1.29A 5js1A-1xe4A:
undetectable		 5js1A-1xe4A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 1xe4 FEMX
(Weissella
viridescens) 		4 / 8 LEU A 289
ILE A 173
ALA A 279
LEU A 152
 None
 0.75A 5y7pC-1xe4A:
undetectable		 5y7pC-1xe4A:
20.48