SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		4 / 8 LEU A 298
VAL A 164
LEU A 200
ALA A 213
 None
 0.94A 1fiqC-1xeaA:
undetectable		 1fiqC-1xeaA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		4 / 5 LEU A 144
GLN A 205
THR A 209
THR A 227
 None
 1.25A 2zj0B-1xeaA:
6.1		 2zj0B-1xeaA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		4 / 6 HIS A  70
LEU A  60
ILE A   5
LEU A  84
 None
 0.96A 3kk6A-1xeaA:
undetectable		 3kk6A-1xeaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		4 / 5 TYR A  56
ILE A  28
LEU A   3
LYS A   4
 None
 1.30A 3sueC-1xeaA:
undetectable		 3sueC-1xeaA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		3 / 3 ARG A 123
PRO A  95
PHE A 121
 None
 0.99A 3thrC-1xeaA:
undetectable		 3thrC-1xeaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		5 / 12 GLY A   9
GLY A  11
LEU A  19
GLN A  15
ILE A   8
 None
 0.96A 4fr0A-1xeaA:
4.6		 4fr0A-1xeaA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		5 / 12 LEU A  86
VAL A  67
VAL A  59
TYR A  56
PRO A  89
 None
 1.38A 4g1qA-1xeaA:
0.0		 4g1qA-1xeaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		5 / 12 LEU A  86
VAL A  67
VAL A  59
TYR A  56
PRO A  89
 None
 1.38A 4id5A-1xeaA:
0.0		 4id5A-1xeaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		5 / 12 LEU A  86
VAL A  67
VAL A  59
TYR A  56
PRO A  89
 None
 1.40A 4ifvA-1xeaA:
0.0		 4ifvA-1xeaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		5 / 12 LEU A  86
VAL A  67
VAL A  59
TYR A  56
PRO A  89
 None
 1.37A 4ifyA-1xeaA:
0.0		 4ifyA-1xeaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		5 / 12 LEU A  86
VAL A  67
VAL A  59
TYR A  56
PRO A  89
 None
 1.35A 4ig3A-1xeaA:
0.0		 4ig3A-1xeaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		5 / 12 LEU A  86
VAL A  67
VAL A  59
TYR A  56
PRO A  89
 None
 1.47A 4kfbA-1xeaA:
0.0		 4kfbA-1xeaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		3 / 3 ASN A 122
ASP A  93
ASP A  12
 None
 0.83A 4obwD-1xeaA:
4.8		 4obwD-1xeaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		3 / 3 LEU A 211
LEU A 188
ASN A 182
 None
 0.72A 4otwA-1xeaA:
undetectable		 4otwA-1xeaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		4 / 5 PHE A 168
HIS A 296
LEU A 298
PRO A 171
 None
 1.32A 5csyB-1xeaA:
undetectable		 5csyB-1xeaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Vibrio
cholerae) 		3 / 3 LYS A  94
LEU A 106
ILE A  69
 None
 0.73A 5kc0A-1xeaA:
undetectable		 5kc0A-1xeaA:
21.59