SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 1xec DECORIN
(Bos
taurus) 		5 / 11 ILE A 186
PRO A 191
LEU A 194
ASN A 155
VAL A 128
 None
 1.30A 1mrlA-1xecA:
1.4
1mrlB-1xecA:
1.5		 1mrlA-1xecA:
19.51
1mrlB-1xecA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1xec DECORIN
(Bos
taurus) 		3 / 3 THR A 239
LEU A 218
LEU A 173
 None
 0.58A 1mz9C-1xecA:
undetectable		 1mz9C-1xecA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 1xec DECORIN
(Bos
taurus) 		4 / 5 GLU A 103
THR A  54
LEU A  56
LEU A  78
 None
 0.96A 1u18B-1xecA:
undetectable		 1u18B-1xecA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1xec DECORIN
(Bos
taurus) 		4 / 6 LEU A 112
MET A 119
LEU A 126
ILE A 178
 None
 0.95A 1z95A-1xecA:
undetectable		 1z95A-1xecA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1xec DECORIN
(Bos
taurus) 		5 / 12 LEU A 223
SER A 211
VAL A 231
THR A 239
LEU A 197
 None
 1.09A 2japA-1xecA:
undetectable		 2japA-1xecA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1xec DECORIN
(Bos
taurus) 		5 / 12 LEU A 223
SER A 211
VAL A 231
THR A 239
LEU A 197
 None
 1.10A 2japB-1xecA:
undetectable		 2japB-1xecA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1xec DECORIN
(Bos
taurus) 		5 / 12 LEU A 223
SER A 211
VAL A 231
THR A 239
LEU A 197
 None
 1.09A 2japC-1xecA:
undetectable		 2japC-1xecA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1xec DECORIN
(Bos
taurus) 		5 / 12 LEU A 223
SER A 211
VAL A 231
THR A 239
LEU A 197
 None
 1.09A 2japD-1xecA:
undetectable		 2japD-1xecA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1xec DECORIN
(Bos
taurus) 		4 / 5 LEU A 247
GLY A 222
ILE A 204
ILE A 228
 None
 0.83A 2q9rA-1xecA:
undetectable		 2q9rA-1xecA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1xec DECORIN
(Bos
taurus) 		3 / 3 ARG A 127
GLU A 125
SER A  39
 None
 0.84A 2xctD-1xecA:
undetectable		 2xctD-1xecA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xec DECORIN
(Bos
taurus) 		4 / 7 ILE A  82
ILE A  91
LEU A  56
LEU A 123
 None
 0.95A 3adxA-1xecA:
undetectable		 3adxA-1xecA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1xec DECORIN
(Bos
taurus) 		5 / 11 MET A 119
LEU A 112
ILE A  67
LEU A  83
PHE A  96
 None
 1.28A 3fl9C-1xecA:
undetectable		 3fl9C-1xecA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1xec DECORIN
(Bos
taurus) 		5 / 9 MET A 119
LEU A 112
ILE A  67
LEU A  83
PHE A  96
 None
 1.26A 3fl9H-1xecA:
undetectable		 3fl9H-1xecA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xec DECORIN
(Bos
taurus) 		5 / 12 LEU A 199
ASP A 208
LEU A 215
LEU A 190
GLY A 189
 None
 1.23A 3g1uC-1xecA:
undetectable		 3g1uC-1xecA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xec DECORIN
(Bos
taurus) 		5 / 12 LEU A 199
ASP A 208
LEU A 215
LEU A 190
GLY A 189
 None
 1.29A 3glqA-1xecA:
undetectable		 3glqA-1xecA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xec DECORIN
(Bos
taurus) 		5 / 12 LEU A 199
ASP A 208
LEU A 215
LEU A 190
GLY A 189
 None
 1.28A 3glqB-1xecA:
undetectable		 3glqB-1xecA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xec DECORIN
(Bos
taurus) 		4 / 8 LEU A 223
SER A 224
LEU A 236
ILE A 228
 None
 0.92A 3ln1A-1xecA:
undetectable		 3ln1A-1xecA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xec DECORIN
(Bos
taurus) 		4 / 7 LEU A 223
SER A 224
LEU A 236
ILE A 228
 None
 0.94A 3ln1B-1xecA:
undetectable		 3ln1B-1xecA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xec DECORIN
(Bos
taurus) 		5 / 12 LEU A 199
ASP A 208
LEU A 215
LEU A 190
GLY A 189
 None
 1.24A 3n58A-1xecA:
undetectable		 3n58A-1xecA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 1xec DECORIN
(Bos
taurus) 		5 / 12 LEU A 252
LEU A 270
ASN A 273
LEU A 300
VAL A 267
 None
 1.42A 3zqtA-1xecA:
undetectable		 3zqtA-1xecA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xec DECORIN
(Bos
taurus) 		4 / 7 ILE A 265
HIS A 271
VAL A 305
PHE A 283
 None
 1.11A 4a97H-1xecA:
0.0		 4a97H-1xecA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1xec DECORIN
(Bos
taurus) 		4 / 8 ASN A 238
ALA A 209
ASP A 208
ASP A 232
 None
 0.84A 4eyrB-1xecA:
undetectable		 4eyrB-1xecA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1xec DECORIN
(Bos
taurus) 		5 / 12 LEU A 112
VAL A 128
PHE A 141
PHE A 167
LEU A 102
 None
 1.26A 4iaqA-1xecA:
undetectable		 4iaqA-1xecA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1xec DECORIN
(Bos
taurus) 		5 / 12 ILE A 204
ILE A 162
LEU A 190
LEU A 197
ILE A 186
 None
 0.90A 4m2xC-1xecA:
undetectable		 4m2xC-1xecA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1xec DECORIN
(Bos
taurus) 		5 / 12 ALA A 166
GLY A 189
PHE A 167
ILE A 204
THR A 205
 None
 1.14A 4n48B-1xecA:
undetectable		 4n48B-1xecA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 1xec DECORIN
(Bos
taurus) 		4 / 4 ASN A 110
LEU A 112
SER A 108
LEU A 126
 None
 1.34A 5kb5A-1xecA:
undetectable		 5kb5A-1xecA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xec DECORIN
(Bos
taurus) 		3 / 3 LEU A 199
ASN A 238
LEU A 245
 None
 0.66A 6exiA-1xecA:
undetectable		 6exiA-1xecA:
13.00