SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xeu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		4 / 5 LEU A 189
LEU A 167
SER A 157
LEU A 134
 None
 0.83A 1a4lC-1xeuA:
undetectable		 1a4lC-1xeuA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 12 ILE A  43
ASP A  49
LEU A  52
GLY A  51
ALA A  91
 None
 1.16A 1axwA-1xeuA:
undetectable		 1axwA-1xeuA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 10 LEU A 164
LEU A 183
ILE A 177
THR A 155
PHE A 146
 None
 1.06A 1i18A-1xeuA:
undetectable
1i18B-1xeuA:
undetectable		 1i18A-1xeuA:
20.23
1i18B-1xeuA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 10 PHE A 146
LEU A 164
LEU A 183
ILE A 177
THR A 155
 None
 1.06A 1i18A-1xeuA:
undetectable
1i18B-1xeuA:
undetectable		 1i18A-1xeuA:
20.23
1i18B-1xeuA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		4 / 8 LEU A 180
GLY A 181
LEU A 189
PRO A 238
 None
 0.86A 1ya4A-1xeuA:
undetectable		 1ya4A-1xeuA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		4 / 7 LEU A 180
GLY A 181
LEU A 189
PRO A 238
 None
 0.88A 1ya4B-1xeuA:
undetectable		 1ya4B-1xeuA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		3 / 3 ARG A 170
ILE A 211
TRP A 210
 None
 1.15A 3e7iB-1xeuA:
undetectable		 3e7iB-1xeuA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		4 / 7 ASP A 268
TYR A 225
GLN A 293
GLU A 269
 None
 1.27A 3l2vA-1xeuA:
undetectable		 3l2vA-1xeuA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 10 LEU A 164
ILE A 211
VAL A 208
GLY A 201
LEU A 186
 None
 1.09A 3ogpB-1xeuA:
undetectable		 3ogpB-1xeuA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 11 LEU A 191
LEU A 174
ILE A 196
LEU A 202
LEU A 183
 None
 1.08A 4dm8A-1xeuA:
undetectable		 4dm8A-1xeuA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 12 ILE A  43
ASP A  49
LEU A  52
GLY A  51
ALA A  91
 None
 1.21A 4foxD-1xeuA:
undetectable		 4foxD-1xeuA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		4 / 4 LEU A 118
LEU A  90
GLN A  78
GLU A 123
 None
 1.26A 4i41A-1xeuA:
undetectable		 4i41A-1xeuA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		6 / 11 MET A  93
PHE A  47
ALA A  53
ALA A  55
VAL A  77
LEU A  74
 None
 1.39A 4j6cA-1xeuA:
undetectable		 4j6cA-1xeuA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 11 ASP A 190
THR A 283
PHE A 287
LEU A 202
VAL A 208
 None
 1.40A 4kyaA-1xeuA:
undetectable		 4kyaA-1xeuA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 11 ASP A 190
THR A 283
PHE A 287
LEU A 202
VAL A 208
 None
 1.38A 4kyaE-1xeuA:
undetectable		 4kyaE-1xeuA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 11 ASP A 190
THR A 283
PHE A 287
LEU A 202
VAL A 208
 None
 1.40A 4kyaG-1xeuA:
undetectable		 4kyaG-1xeuA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		6 / 10 LEU A 147
LEU A 102
LEU A 115
ILE A 137
LEU A 112
LEU A 158
 None
 1.41A 4odoC-1xeuA:
undetectable		 4odoC-1xeuA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		4 / 7 VAL A 178
ILE A 177
LEU A 145
LEU A 167
 None
 0.98A 4xo7A-1xeuA:
undetectable		 4xo7A-1xeuA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		4 / 7 ILE A 137
GLY A 136
CYH A 141
ASP A 117
 None
 0.86A 5hieB-1xeuA:
undetectable		 5hieB-1xeuA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		4 / 8 ILE A 137
GLY A 136
CYH A 141
ASP A 117
 None
 0.89A 5hieD-1xeuA:
undetectable		 5hieD-1xeuA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		3 / 3 SER A 249
TYR A 272
TYR A 247
 None
 0.87A 5lakA-1xeuA:
undetectable
5lakI-1xeuA:
undetectable		 5lakA-1xeuA:
22.98
5lakI-1xeuA:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 12 PHE A  80
ALA A  55
PHE A  96
GLY A  92
ILE A  87
 None
 0.94A 5m24A-1xeuA:
undetectable		 5m24A-1xeuA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 12 LYS A 162
ASN A 163
GLU A 165
LEU A 164
LEU A 145
 None
 1.16A 5nwvA-1xeuA:
undetectable		 5nwvA-1xeuA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		5 / 12 LEU A 174
ILE A 177
GLY A 181
LEU A 189
PHE A 146
 None
 1.24A 6a7pA-1xeuA:
undetectable		 6a7pA-1xeuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1xeu INTERNALIN C
(Listeria
monocytogenes) 		4 / 7 LEU A 121
VAL A 126
LEU A  90
LEU A 134
 None
 0.72A 6g9bA-1xeuA:
undetectable
6g9bB-1xeuA:
undetectable		 6g9bA-1xeuA:
16.35
6g9bB-1xeuA:
14.62