SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 7 PHE Y1093
LEU X  47
GLY X  52
ILE X 135
 None
 0.82A 1p2yA-1xewY:
undetectable		 1p2yA-1xewY:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 8 TYR X 140
ASN X 141
GLY X 139
THR X 131
 None
 0.87A 1ykiA-1xewX:
0.0
1ykiB-1xewX:
0.0		 1ykiA-1xewX:
21.61
1ykiB-1xewX:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 8 THR X 131
TYR X 140
ASN X 141
GLY X 139
 None
 0.89A 1ykiA-1xewX:
0.0
1ykiB-1xewX:
0.0		 1ykiA-1xewX:
21.61
1ykiB-1xewX:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 8 TYR X 140
ASN X 141
GLY X 139
THR X 131
 None
 0.86A 1ykiC-1xewX:
undetectable
1ykiD-1xewX:
undetectable		 1ykiC-1xewX:
21.61
1ykiD-1xewX:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 8 THR X 131
TYR X 140
ASN X 141
GLY X 139
 None
 0.85A 1ykiC-1xewX:
undetectable
1ykiD-1xewX:
undetectable		 1ykiC-1xewX:
21.61
1ykiD-1xewX:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 12 VAL X  82
VAL X  20
THR X  29
VAL Y1152
GLY X  43
 None
 1.15A 2cbrA-1xewX:
1.3		 2cbrA-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 12 PHE Y1093
LYS X  26
ILE X  84
PHE X  86
GLY X  43
 None
 1.09A 2lbdA-1xewY:
undetectable		 2lbdA-1xewY:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 11 ILE Y1099
PHE Y1124
PHE Y1096
VAL X 143
THR Y1128
 None
 1.10A 2w3aA-1xewY:
undetectable		 2w3aA-1xewY:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 7 PHE X  12
TYR X  15
VAL X  82
ILE X  84
 None
 0.94A 4a97E-1xewX:
undetectable		 4a97E-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 8 PHE X  12
TYR X  15
VAL X  82
ILE X  84
 None
 0.92A 4a97C-1xewX:
undetectable		 4a97C-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 8 PHE X  12
TYR X  15
VAL X  82
ILE X  84
 None
 0.92A 4a97D-1xewX:
undetectable		 4a97D-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 8 PHE X  12
TYR X  15
VAL X  82
ILE X  84
 None
 0.97A 4a97G-1xewX:
undetectable		 4a97G-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 7 PHE X  12
TYR X  15
VAL X  82
ILE X  84
 None
 0.97A 4a97H-1xewX:
undetectable		 4a97H-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		3 / 3 ASN X  41
LEU Y1095
PHE X  48
 None
 0.77A 4dajB-1xewX:
undetectable		 4dajB-1xewX:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 8 THR X 149
MET Y1069
GLY Y1071
GLY Y1072
 None
 0.75A 4qvvK-1xewX:
undetectable
4qvvL-1xewX:
undetectable		 4qvvK-1xewX:
22.81
4qvvL-1xewX:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 8 THR X 149
MET Y1069
GLY Y1071
GLY Y1072
 None
 0.75A 4qvvY-1xewX:
undetectable
4qvvZ-1xewX:
undetectable		 4qvvY-1xewX:
22.81
4qvvZ-1xewX:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		3 / 3 ASN X  41
LEU Y1095
PHE X  48
 None
 0.78A 5dsgA-1xewX:
undetectable		 5dsgA-1xewX:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 10 ILE X 135
GLY X 139
PHE X  86
LEU Y1095
LEU X 144
 None
 1.16A 5fhzC-1xewX:
undetectable		 5fhzC-1xewX:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 11 VAL Y1126
ILE Y1125
ILE X  22
ILE Y1167
ILE Y1163
 None
 1.03A 5hw8A-1xewY:
undetectable
5hw8D-1xewY:
undetectable		 5hw8A-1xewY:
22.41
5hw8D-1xewY:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU Y1155
ILE X  42
GLY X  38
VAL Y1153
ILE Y1141
 None
 1.14A 5kqyA-1xewY:
undetectable		 5kqyA-1xewY:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 9 ALA X  30
THR X  29
ALA Y1137
GLY Y1142
ALA Y1160
 None
 1.09A 5l5zY-1xewX:
undetectable
5l5zZ-1xewX:
undetectable		 5l5zY-1xewX:
20.09
5l5zZ-1xewX:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 1xew SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 7 LEU X 127
PHE Y1093
GLY X  43
GLY X  52
 None
 0.80A 6eu9D-1xewX:
undetectable		 6eu9D-1xewX:
18.34